1 Star2 Stars3 Stars4 Stars5 Stars (1 votes, average: 5.00 out of 5)

Uses of Prednisolone (Prelone)

Last updated on: November 3rd, 2021

Prednisolone is a synthetic oral medication that resembles cortisol in its action, with the only difference that cortisol occurs naturally in the body, and Prednisolone is a man-made substance. On the one hand, the medicine is meant to suppress the immune system and, on the other hand, is called to reduce inflammation linked to conditions such as Crohn’s disease, asthma, psoriasis, and even leukemia.  

The human adrenal gland is known to produce the corticosteroid hormone involved in a large number of physiological processes. When patients have a twisted production of this hormone, they are prescribed Prednisolone to ensure that all the processes that require this hormone run well. In a nutshell, the medicine is used to treat complicated medical conditions such as arthritis, bronchitis, diseases of the eyes and skin, different allergies, blood problems (anemia), and immune system disorders, especially autoimmune diseases.

What is Prednisolone (Prelone)

As someone prescribed Prelone, you might be wondering, ‘What is the medicine Prednisolone?’, ‘How does this drug work?’ Answering the question, ‘What is Prednisolone generally used for?’, it is necessary to mention its nature. In a narrower sense, Prednisolone is a prescription steroid drug coming in the form of tablets. There are either immediate-release tablets and delayed-release tablets or a liquid form.  

How Does it Work

Prednisolone is the agent that weakens the response of a person’s immune system for the sake of reducing inflammation in certain parts of the body or its systems. Like other corticosteroids, the hormone has powerful anti-inflammatory effects. Typically, the medicine shows good results when dealing with illnesses that strongly depend on the immune system. To be more precise, Prednisolone is the active metabolite of the substance called Prednisone, causing the inhibition of the chemicals that drive inflammation. The substance is first metabolized in the liver and later becomes able to enter cellular membranes. Because this drug has a high similarity with cytoplasmic receptors, it can decrease the synthesis of protein at the same time inhibiting leukocyte infiltration. 

Is it Safe

Since the key responsibility of this drug is to make your immune system less active, it will significantly lower your body’s ability to fight infections and viruses. So, you need to understand how careful you must be during the time when you take it as prescribed by the doctor. At this time, any infection can lead to a fatal ending. Anyway, this is another reason to be as transparent and honest with your doctor as possible concerning any symptoms of infection disease – sneezing, coughing, fever, sore throat, etc. Besides, a lasting therapy results in adrenal glands atrophy and the total stop of the body’s own cortisol production.

What Is Prednisolone Used For

Diseases and medical conditions treated or reduced by the drug include a whole list of serious illnesses. Among the most frequent reasons for taking Prelone, there are the following:

  • Asthma
  • Ulcerative colitis
  • Autoimmune hemolytic anemia
  • Lymphomas
  • Eye ulcer
  • Bronchitis
  • Dermatitis of different types
  • Systemic lupus
  • Allergies
  • Disorders of the endocrine system
  • Bursitis of joints
  • Nephrotic syndrome
  • Optic neuritis

The effect of Prelone can be compared to the effects of other corticosteroid drugs for the same implications, such as Kenacort, Medrol, or Decadrone. The medicine is famous under several brand names like Rayos, Prednisone Intensol and is approved by the US Food and Drug Administration in 1995 and is successfully used to treat the conditions mentioned above with exceptions for patients with a few other diseases. In drugstores, Prednisolone is available as a syrup, usually 5 mg, in variations with different strengths that can be seen in the chart below.

Commercially available prednisolone liquid products


Systemic Lupus Erythematosus, or SLE, commonly known as lupus, is a chronic autoimmune disease characterized by the production of harmful antibodies in the blood. The condition is supposed to develop as a result of certain drug intake, viruses, and, perhaps, heredity. Contemporary medicine has learned to control this condition with the help of Prednisolone along with other medications such as cytotoxic drugs for more difficult cases of SLE.


This lung disorder also develops on the basis of chronic lung inflammation accompanied by breathing difficulty, coughing, and tightness. Together with the elimination of the main asthma triggers, spasms in the bronchi, and chronic inflammation, asthma can be kept under control. Corticosteroids, in this case, are mainly used as inhaled medicines.


Systemic corticosteroids like Prelone, either in the form of tablets or injections, are effectively used for treating skin diseases and rashes, but the intake of the medication must be discussed with the doctor first. 

Certain Types Of Arthritis

Rheumatoid arthritis is one of many autoimmune diseases that is curable with the drug. The uses of tablets of Prednisolone are also highly productive for gout and psoriatic arthritis regardless of the number of joints that require treatment.

What Do I Need To Tell My Doctor Before I Take Prelone

Now, the first thing to immediately tell your doctor is if you are allergic to any component in the tablets or syrup. Being allergic to Prednisolone will exclude the possibility of therapy and make your physician seek other ways to overcome the disease. Secondly, inform the doctor about any other food or substance that you don’t tolerate and the symptoms that are common for you. Thorough screening of liver and eye nerves and checking for any eye problems is also compulsory, so make sure you tell the doctor about any slightest discomfort if there is such.

Another important aspect to discuss with the professional includes other medicines you’ve been taking, herbal medications, and vitamin supplements.  

How to Use This Medicine

The intake of this medicine in the form of syrup should be individualized and adjusted to the severity of a patient’s condition and the response to treatment. Each teaspoon of the cherry-flavored syrup contains 15mg of Prednisolone. The medication comes with a leaflet, so it is vital to read it first and consult your doctor if you’ve got any doubts. The suspension should be measured; however, not with an average teaspoon but with a syringe that comes in the pack to avoid mistakes in the dosage. The medicine is to be stored at room temperature in the original container, away from severe heat, extra moisture, and direct sun rays. It also mustn’t be frozen.

Prelone is often allowed to be taken with food to avoid the irritation of the stomach, especially at the initial stages of treatment. Dosage requirements are highly variable and must be kept under the careful observation of the doctor since the overdose is especially hazardous. If you were prescribed a prolonged course of treatment, make sure your medical checkups are regular, and there are no undesirable effects showing up.


As mentioned previously, every dose should be different for every individual relying on their disease type, its progress, and individual reaction. The following data includes only the average doses of this medicine and cannot be used as an instruction to action.

The amount of the syrup or the amount of tablets to take depends on several key factors – the strength of the drug and the frequency of taking it. Generally, any oral dosage solution (syrup, tablets, suspension) for adults varies from 5 to 60 mg a day.

Prednisolone dosage for asthma, for instance, includes 50 to 100 mg of Prednisolone a day (taken for 5-10 days) for adults. This dosage in medical practice shows the maximum efficacy. When it comes to the dosage of Prednisolone for kids 2 to 15 years old, three to five full days of the treatment are assigned with 1 mg per kilogram of body weight. 

How is it Best Taken

Experts in the treatment of various types of diseases with Prednisolone claim that it’s best if you take it as a single dose once a day, ideally after breakfast. This is the perfect time for taking the full dose since taken in the morning, it won’t affect your sleep leading to insomnia, and is not likely to upset your stomach. Most of the medications containing Prednisolone are not labeled as ‘gastro-resistant,’ which means they could have irritating effects on your stomach. In case extra sensitivity to the drug is spotted, make sure you choose the ‘gastro resistant’ tablets that can otherwise be named ‘enteric-coated.’


To prevent patients from acquiring bad conditions or developing their other illnesses, a set of cautiousness measures is to be regarded. First and foremost, there are certain categories of people who are not allowed to take the medicine:

  • Those having infections or getting well from them;
  • Those who are trying to get pregnant, are already pregnant, or plan to breastfeed;
  • People who were in contact with carriers of measles, chickenpox, or shingles;
  • Those having experienced vaccination recently;
  • People with serious liver problems.

Conditions such as epilepsy, depression, heart failure, or a recently experienced heart attack, diabetes, and high blood pressure might also become valid reasons for your doctor not to let you take the medication since side effects in these cases are not easily predicted.

What Do I Do If I Miss a Dose

Just like with any other medication of similar purpose and type, a missed dose of Prelone should be taken as soon as a patient remembers to do it (on the same day). If the dosage for that day is missed, do not try to take a double dosage to catch up. Just skip the missed dose and continue to keep up with the scheduled intake.

Drug Interactions and Warnings

Prednisolone interacts with a number of medications and substances, so all drugs taken simultaneously with Prelone should be discussed with the health professional. The especially hazardous effects are observed in the combination of Prednisolone with drugs like Aricept, Exelone, and Razadyne (as a part of anticholinesterase therapy). Injections of medical supplements like Ambisome can increase the risks of a heart attack. Other medicines don’t pose serious threats but make Prednisolone totally ineffective – this category contains the popular Coumadin and many antibiotics.

What Happens If I Overdose

Accidental overdose is not supposed to bring any serious damage to your health. However, continuous and long-term intake of the increased dose might result in thinning skin and acne, easy bruising and blood vessels becoming very fragile, issues with menstrual cycle, and impotence.

Can You Use Prednisolone During Pregnancy

The drug has not been tested on pregnant women, and that is why medicine lacks evidence concerning the drug intake at this period of life. That is why Prednisolone is usually not advised to use during pregnancy until there are certain health benefits that seriously outweigh the dangers.

Occasional intake of Prednisolone is linked to hazards for the baby in the first 12 weeks of pregnancy. However, the long use of Prelone holds more threats for an unborn kid. If you are concerned about the dosage of Prednisolone during your pregnancy or lactation or want to make sure that the benefits outweigh the minuses in your situation, consult your doctor and read the information on the Best Use of Medicines in Pregnancy (BUMPs).

Prednisolone Side Effects

Normally, doses under 20 mg a day don’t cause strong side effects. Still, some patients may experience unwanted side effects when they take it longer than 14 days.

The harshest Prednisolone or Prelone side effects include these:

  1. Being breathless, troubled breathing, and talking.
  2. Fever and chill.
  3. Increased production of saliva or unusual color of it.
  4. Wounds and mouth sores that heal slowly.
  5. Weight gain, especially in the upper part of the back and tummy.
  6. Vomiting, dizziness, passing out, and bad headaches.
  7. Radical changes in vision.
  8. Severe back pain, stomach pain.
  9. Heartbeat that does not feel healthy.

Research in 2018 concerning side effects of Prelone for treating asthma revealed many other adverse events.

More Common

If the dosage you were prescribed is safe and you follow it, there still could be slight side effects that occur in many cases and don’t create situations when you need emergency hospitalization. They are:

  • Headaches
  • Vomiting
  • Nausea
  • ‘Moon face’
  • The feeling of restlessness
  • Sweating too much
  • Weight gain
  • Troubled sleep
  • Indigestion

Common prednisone side effects

Prednisone and facial swelling

These issues can be coped with. For example, if you notice extra kilos come, try to eat a balanced diet without increasing the size of portions even if the appetite is increased. Regular exercising will also help you avoid stress and overeating at the background of treatment. Indigestion can easily be overcome with a single tip – taking Prednisolone with a meal. Make sure you avoid fatty or spicy foods during the therapy; if this doesn’t work, consult your doctor about the additional medicine to control indigestion and irritated stomach.

How to prevent prednisone weight gain

Serious Allergic Reaction

Allergic-type reactions to Prelone are less widespread. They occur mostly due to the hypersensitivity to the key component that a patient didn’t know about and include swelling of lips, tongue, and neck, skin rash, hives, itches, breathing problems, etc.

Prednisolone For Kids

It is vital to inform the adults that long periods of taking Prelone interfere with the normal growth and development of kids and teenagers. If the doctor notices any serious changes or inhibition of growth, they would change the treatment plan to minimize the harm.

Prednisone Vs. Prednisolone

Prednisolone and Prednisone are both corticosteroids effective for curing asthma, dermatitis, severe allergies, and a set of other diseases. Prednisone is broken down to Prednisolone in the human liver. Both substances are effective for treatment, with the only difference that many drug brands make Prednisolone in a ‘milder form’ to be taken by people with liver impairments and help them overcome severe conditions. Prednisone is, in its turn, more often available in higher doses, making it easier to consume a daily dose with fewer tablets. Discuss with your doctor what to choose best – Prednisone (Prelone) vs Prednisolone.




Congenital adrenal hyperplasia



Nonsuppurative thyroiditis



Rheumatoid arthritis



Ankylosing spondylitis



Acute bursitis



Synovitis of osteoarthritis



Psoriatic arthritis



Systemic lupus erythematosus



Severe seborrheic dermatitis



Severe psoriasis



Optic neuritis



Allergic corneal marginal ulcers



Herpes zoster ophthalmicus



Anterior segment inflammation



Allergic conjunctivitis



Symptomatic sarcoidosis



Aspiration pneumonitis



Idiopathic thrombocytopenic purpura



Ulcerative colitis



Acute exacerbations of Multiple Sclerosis



Prednisolone for Cats and Dogs

The popular corticosteroid is also used to help cure pets of cancer, allergies, and autoimmune problems such as AD since the substance is bioavailable for them, too. However, every change of dosage of Prednisolone must be discussed with the veterinarian. Prednisolone for dogs also has many side effects, one of which is significant weight loss, especially in dogs with diabetes.

When curing diabetes in pets, Prednisolone makes them accumulate fat while getting rid of muscle mass. Steroid treatment in cats is an extreme measure, so doctors advise to either use short-term treatment or pick other medicine. Prednisolone for cats and dogs can often be life-saving but watch your pet be examined regularly so that no Prednisolone side effects overweight the usefulness.

Leave a Reply
1 Comment threads
0 Thread replies
Most reacted comment
Hottest comment thread
1 Comment authors
newest oldest most voted
Notify of
gub yubb

Drugs is injurious to health. Only use the prescribed dugs.