Mode of action – anti-inflammatory, analgetic, antipyretic. The mechanism of action connected with the blockade of cyclooxygenase, which leads to disruption of metabolism of arachidonic acid and reducing concentrations of GHGs. Suppresses exudative and proliferative processes in the inflammation, reduces the concentration of bradykinin and histamine, but also increases the threshold of sensitivity of pain receptors.
NSAIDs are very widely used in almost all the departments of medicine. By some estimates, each year in the world more than 60 million prescriptions of non-aspirin NSAIDs are being produced. However, the actual number of patients taking NSAIDs is much more, since this medication is approved for use as a non-prescription medicines.
The action of NSAIDs at the cellular level is associated with the inhibition of the enzyme cyclooxygenase-2 (COX-2), which leads to disruption of the synthesis of prostaglandins (PG) – proinflammatory cytokines.
Anti-inflammatory effect is manifested at weakening stage of exudation (edema) and proliferation (proliferation of connective tissue). Violation of PG synthesis leads to a decrease of the selection of biologically active substances that activate inflammation (histamine, serotonin), increase membrane permeability and increase swelling. Reduction of edema happens due to the normalization of the vascular permeability of membranes during inflammation. Important role in the anti-inflammatory effect of NSAIDs is played by their antioxidants whose main property is to inhibit lipid peroxidation (LPO), the products of which are the free radicals that damage biological membranestion, therefore contributing to the progression of inflammation.
NSAIDs have a broad spectrum of side effects, including the three major groups: NSAID-induced gastropathy, drug damaged articular cartilage, and cardiovascular complications. The greatest number of side effects is associated with disorders of the gastrointestinal tract. Minimal (but not eliminated) risk of side effects on the gastrointestinal tract is caused by preferential and selective COX-2 blockers, which requires a combination of them with a proton pump blockers (omeprazole and others).
Azulfidine – a drug with anti-microbial and anti-inflammatory properties. By its chemical structure is a combination of sulfapiridin and 5-aminosalitsil acid. A small portion of sulfazalazin is absorbed from the lumen of the colon, and then evenly distributed within the connective tissue.
Ponstel belongs to a nonsteroidal anti-inflammatory medications. It is recommended to take in moderate pain as well as menstrual pain.
This drug belongs to a nonsteroidal anti-inflammatory medicines (NSAID). It is recommended to treat such symptoms as inflammation, pain and fever. This medication possesses the same effect as naproxen (Naprosyn, Aleve) and ibuprofen (Motrin).
On the spectrum of antimicrobial effect it is similar to penicillin. The drug is active against gram-positive and Gram-negative microorganisms (meningococci, streptococci, pneumococci, staphylococci, gonococci).
Naprosyn is known as a nonsteroidal anti-inflammatory drug. It is used to relieve the stiffness, inflammation, swelling and joint pain which are associated with ankylosing spondylitis (spinal arthritis), juvenile arthritis, bursitis, acute gout, tendinitis, osteoarthritis (the most common form of arthritis), rheumatoid arthritis.
Asacol (mesalamine) is known as a popular delayed-release medicine. It curtails diarrhea, ulcerative colitis, proctosigmoiditis, signs of ulcerative colitis from recurring. Apprise your medic or pharmacist for more information about the salutary influence of this product.
Aristocort is used in treating of some medical conditions, such as insufficiency of the inflammatory disorders, adrenal cortex, allergic disorders and connective tissue disorders. Aristocort can also be prescribed for other purposes and not mentioned here.
Mobic is considered to be a popular drug that is classified as NSAID. It is often recommended to treat fever, stiffness, osteoarthritis, pain, tenderness, inflammation, arthritis, dysmenorrhea. Mobic intensifies sensitivity to sunlight, it may cause severe burning.
Has anti-inflammatory, analgesic and antipyretic effect. Inhibits synthesis of prostaglandins.
Celebrex is a combination which belongs to the group of coxibs. It is taken to treat rheumatoid arthritis, osteoarthritis, painful menstruation and menstrual symptoms, acute pain, as well as for reduction of the number of polyps of the colon and rectum in people with family adenomatous polyposis. A few words about how Celebrex works.
Arcoxia belongs to the type of drugs called NSAIDs. Selective COX-2 inhibitor, it is used to block the formation of prostaglandins. This remedy provides antipyretic, analgesic, anti-inflammatory effect.
Diplorene belongs to topical steroid. It helps to reduce the actions of chemicals in the body that cause swelling, inflammation and redness.
Motrin is a nonsteroidal anti-inflammatory remedy which is sold in both nonprescription and prescription forms. This pill can be prescribed for adults to cure the osteoarthritis and rheumatoid arthritis It is prescribed to treat menstrual pain. It provides relief in case of mild and moderate pain.
Estrogens can be found in nature in several forms. Estrogen is a female hormone which is necessary for many processes in organism.
Arava is used in patients suffering from rheumatoid arthritis for regulating the symptoms of the desease as well ass structural damage of the bones prevention. Arava gives a boost to the physical function of the joints. In case you miss your Arava dose you should take the missed dose as soon as you remember to.