Hyzaar (Losartan-hydrochlorothiazide)

Last updated on February 16th, 2024

Generic name: Losartan-Hydrochlorothiazide

Brand name: Hyzaar

General Information:

Hyzaar is taken to cure high blood pressure. This drug is a combination of 2 medications (an angiotensin receptor blocker and a thiazide “water pill”/diuretic). Hyzaar relaxes blood vessels, widening them The thiazide diuretic extends the amount of urine, therefore curtailing excess water and salt in your body. Controlling your blood pressure will help to avoid heart attacks, strokes and kidney problems.

Your doctor may prescribe this remedy for other purposes. Contact your physician if you need to learn more information about this drug.

Don’t stop treatment with Hyzaar earlier than it was prescribed by your doctor even if you notice improvements of your condition. Stopping the medication too early may worsen your condition. Be careful about doing dangerous tasks, driving, operating machinery or climbing until you are aware how this drug affects you. Don’t drink alcohol. Always contact a medic before giving Hyzaar to a child.

What symptoms or conditions should I report to a doctor before I take this medicine?

It is important to report to a doctor if you have or had the following conditions:

  • asthma or allergies
  • lupus
  • an allergy to sulfa drugs
  • kidney or liver disease
  • gout
  • low or high levels of potassium in your blood
  • congestive heart failure
  • diabetes

Hyzaar Losartan/Hidrochlorothiazide 50/12.5 mg 30 tabs

How do I take this medicine?

Note: This remedy was prescribed to you only. Don’t share this medicament with others. Follow strictly your doctor’s recommendations. Don’t take more or longer than your doctor recommended.

This drug is taken orally with food, milk or an antacid to prevent stomach upset. You may also take it with a full glass of water unless your doctor directs you otherwise. Do not lie down for 30 minutes after taking this drug. Take the doses at regular intervals.


Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.

In large doses, this remedy may cause the following conditions:

  • fainting
  • feeling light-headed
  • slow heartbeat

If you forget about a dose:

In case you forgot to take the dose, take it at your earliest opportunity. Never double your dose if it is almost time for your next dose. Take only one dose at once.


  • insulin or diabetes medications taken orally
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren, Cataflam), ibuprofen (Advil, Motrin), indomethacin (Indocin), etodolac (Lodine), naproxen (Naprosyn, Aleve), nabumetone (Relafen), piroxicam (Feldene), meloxicam (Mobic) and others
  • celecoxib (Celebrex)
  • any other diuretics, such as bumetanide (Bumex), amiloride (Midamor), hydrochlorothiazide (Zestoretic, HydroDiuril, HCTZ, Lopressor HCT, Hyzaar, Vasoretic),  furosemide (Lasix), torsemide (Demadex), spironolactone (Aldactone) and others
  • a muscle relaxer such as carisoprodol (Soma), baclofen (Lioresal), methocarbamol (Robaxin), cyclobenzaprine (Flexeril), tizanidine (Zanaflex) and others
  • any other blood pressure medications
  • lithium (Lithobid, Eskalith)
  • a barbiturate such as phenobarbital (Solfoton, Luminal) and others
  • steroids (prednisone and others)
  • rifampin (Rimactane, Rifadin, Rifater)
  • cholestyramine (Questran, Prevalite) or colestipol (Colestid)
  • narcotic pain medication such as fentanyl (Duragesic, Actiq), codeine (Cheratuss, Tylenol #3, Guaiatuss AC), hydromorphone (Dilaudid), hydrocodone (Vicodin, Lortab, Vicoprofen), morphine (Kadian, Avinza, Oramorph, MS Contin), methadone (Methadose, Dolophine), propoxyphene (Propacet, Darvocet), or oxycodone (Endocet, OxyContin, Percocet)

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.

Hyzaar Losartan/Hidrochlorothiazide 100/12.5 mg 30 tabs

Side Effects:

Contact your physician immediately if you notice any of the following serious side effects:

  • allergy like skin rash, swelling of the face, lips, tongue, hives, itching, difficulty breathing
  • urinating less than usual, or not at all, increased urination
  • rapid weight gain
  • fainting
  • swelling
  • pale skin
  • feeling light-headed
  • fast or pounding heartbeats, fast heart rate
  • drowsiness
  • easy bruising or bleeding
  • dry mouth, increased thirst
  • jaundice (yellowing of the skin or eyes
  • restless feeling
  • seizure (convulsions)
  • confusion

Less serious side effects:

  • skin rash
  • back pain
  • stomach pain
  • dry cough
  • sore throat
  • tired feeling
  • dizziness
  • runny or stuffy nose

This list of side effects may be not complete, others may occur. Inform your medical practitioners about all side effects you experience.

Important Information:

Avoid becoming overheated or dehydrated during exercise and in hot weather. Consult your doctor about how much liquids you should drink during a day. Avoid potassium supplements or salt substitutes during treatment unless your physician recommends you otherwise. This drug can cause serious fetal harm (possibly death) if used during the last six months of pregnancy. If you become pregnant or think you may be pregnant, talk to your doctor immediately. Avoid standing or sitting up quickly, especially if you are an older patient. Check your blood pressure regularly. Your kidney function may also need to be tested.


Hyzaar should be stored at room temperature, in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Hyzaar out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor. The information contained in this article is not intended to cover all possible precautions, drug interactions, adverse effects, directions, uses, allergic reactions or warnings.

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