Last updated on April 13th, 2024

General Information

Azulfidine is a medication that has anti-inflammatory and anti-microbial qualities. It is a mixture of 5-aminosalicylic acid and sulfapiridin. The medication is absorbed in small amounts from the colon’s lumen and then evenly distributed within the connective tissue. Because Azulfidine is more readily absorbed (up to 30% of the dose), it primarily has a broad anti-inflammatory effect.

According to the National Library of Medicine, Azulfidine is prescribed for the following conditions:

  1. Rheumatoid arthritis.
  2. Polyarticular Juvenile Idiopathic Arthritis.
  3. Ulcerative colitis.

There are also non-FDA approved (off-label) indications:

  • Ankylosing Spondylitis;
  • Crohn’s Disease;
  • Psoriatic Arthritis.

See your physician before using the medication.

How to Take

Azulfidine is given with 240–250 ml of drinking water, preferably before meals.


Side Effects and Contraindications

Side effects frequently occur when the medication builds up a high concentration in the blood plasma. Patients with delayed occurrence of sulfapiridin acetylation rate may experience such a condition. Itchy skin, fever, headaches, gastrointestinal tract issues, and erythema are common adverse effects of the medication.


  • hypersensitivity to the medication’s ingredients;
  • severe liver and kidney conditions;
  • up to two years of age.

Period of Pregnancy and Nursing

Pregnancy-related use of Azulfidine is permitted, but only in extreme cases. Expectant mothers are advised to select the lowest effective dosage. Breastfeeding is discontinued if medication is required because it is well excreted in breast milk.


Digoxin and folic acid are less absorbed when taking Azulfidine, which strengthens the anticoagulant agents.

Please keep Azulfidine at a temperature of no more than 25°C in a dark place.


Is Azulfidine appropriate for continuous use?

Indeed, long-term prescriptions for Azulfidine are frequently given to treat diseases like inflammatory bowel disease and rheumatoid arthritis. Your physician will monitor your reaction and change the dosage as needed to keep the drug working as intended and reduce adverse effects.

How soon does Azulfidine begin to work?

Depending on the disease being treated, Azulfidine has different times when it starts to work. After beginning treatment, some patients with inflammatory bowel disease may show improvements in a few weeks. Nevertheless, it could take a few weeks to months for patients with diseases like rheumatoid arthritis to fully benefit from Azulfidine medication. It’s crucial to follow all your doctor’s recommendations and be patient while waiting for the medication to start working.

When taking Azulfidine, are there any particular dietary requirements to be aware of?

Using Azulfidine does not require any food restrictions. However, some people may have gastrointestinal side effects such as nausea, vomiting, or appetite loss. Taking Azulfidine with meals or a full glass of water might be beneficial to reduce these side effects. During Azulfidine medication, maintaining hydration and eating a well-balanced, nutrient- and fiber-rich diet can also help maintain overall digestive health.

Can I drink alcohol when taking Azulfidine?

It is usually advised to minimize or stay away from alcohol when taking Azulfidine. Alcohol use may raise the possibility of some adverse effects, which are already possible risks associated with the use of Azulfidine, such as liver damage and gastrointestinal discomfort. Make sure you talk to your doctor about any alcohol you may be consuming to find out what amount, if any, is safe for you to consume while taking Azulfidine.


0 0 votes
Article Rating
Notify of
Inline Feedbacks
View all comments