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Last updated on November 21st, 2021

Generic name: Adapin

Brand names: Adapin, Aponal, Sinequan, Doxepin, Zonalon, Prudoxin, Deptran, Xepin

What is Sinequan?

Sinequan is a popular medication that is known as a tetracyclic antidepressant. It prescribed for the treatment of psychotic depressive disorders, depression, posttraumatic stress disorder (PTSD) and anxiety, including clues of fibromyalgia and chronic pain.

Sinequan as tricyclic antidepressants should not be used with monoamine oxidase inhibiting drugs (MAOI) because high fever, convulsions, and even death may occur from such combinations.

Sinequan is not approved for use in children under 12. Always tell a health care professional before giving Sinequan to a child.

Your doctor may prescribe this remedy for other purposes. Contact your physician if you need to learn more information about this drug.

Don’t stop treatment with Sinequan earlier than it was prescribed by your doctor even if you notice improvements of your condition. Stopping the medication too early may worsen your condition. Be careful about doing dangerous tasks, driving, operating machinery or climbing until you are aware how this drug affects you.

What symptoms or conditions should I report to a doctor before I take this medicine?

It is important to report to a doctor if you have or had the following conditions:

  •     heart disorders, heart attack, stroke, or high blood pressure
  •     liver or kidney disease
  •     an unusual or allergic reaction to doxepin, other medicines, foods, dyes, or preservatives
  •     asthma
  •     diabetes
  •     an enlarged prostate or difficulty urinating
  •     stomach or intestinal problems
  •     seizures or epilepsy
  •     glaucoma
  •     pregnancy, breastfeeding or planning to become pregnant

How to take Sinequan?

Note: This remedy was prescribed to you only. Do not share this medicament with others. Follow strictly your doctor’s prescription. Do not take more or longer than your doctor recommended.

This medicament is presented in the capsule or form of capsules or liquid to take by mouth.

The recommended starting dose of this medicine is 25 mg. It is usually recommended to take medicine 1 to 3 times daily, at around the same time(s) every day. Dosages above 500 mg per day are not recommended.

This medicine is usually accompanied by some liquid. It is important to drink several glasses of water each day while you are taking Sinequan to protect your kidneys. You may take it on a full or on an empty stomach. In order to minimize stomach irritation and help your body absorb the drug is advisable to combine with food.

The capsules should be swallowed whole. Do not crush, break, chew or open them. Shake the suspension well before each use to mix the medication evenly. Use a specially marked measuring spoon or medicine cup to be sure of the correct dose. Do not use this amount unless your health care provider specifically instructs you to do so.

What should be done if I missed the dose?

In case you forgot to take the dose, take it at your earliest opportunity. Never double your dose if it is almost time for your next dose. Take only one dose at once.


Taking any medicine in large doses you can have serious consequences for your health. If you are overdosed visit your doctor straightway.

In large doses, Sinequan may cause coma, delirium, shock or agitation.


  •     Anticholinergic medications (Atropine, Belladonna, Clidinium, Dicyclomine, Glycopyrrolate)
  •     Arrhythmia medications (Amiodarone, Disopyramide, Flecainide, Propafenone)
  •     Cimetidine (Tagamet)
  •     Phenothiazine medications (Chlorpromazine, Trifluoperazine, Thioridazine)
  •     SSRI or SNRI medications (Citalopram, Escitalopram, Sertraline)
  •     Tolazamide (Tolinase)
  •     tricyclic antidepressants (Amitriptyline, Maprotiline, Trimipramine)

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.

Which side effects can I perceive from this remedy?

  •     Allergic reaction (difficulty breathing; skin rash or swelling; swelling of your throat, lips, tongue or face; hives; itching)
  •     Loss of appetite
  •     Weight changes
  •     Fast/pounding/irregular heartbeat (palpitations)
  •     Mental, mood changes (abnormal dreams, abnormal thinking, gloss of contact with reality, restlessness, confusion, hallucinations, blurred vision)
  •     Problems with breathing, chest pain
  •     Sore throat, chills, and fever
  •     Numbness, tingling in your hands or feet (tremor), muscle stiffness, or spasms
  •     Indigestion, or upset stomach, bloating, stomach gas, pain or cramps
  •     Nausea, vomiting
  •     Unusual bleeding or bruising
  •     Headache, dizziness, ringing in your ears or hearing loss
  •     Difficulty urinating (urinary retention), diarrhea
  •     Low blood pressure
  •     Liver problems, yellowing eyes, skin

If these persist or worsen, notify your doctor immediately. This is not a complete list of side effects and others may occur. If you have other reactions not mentioned above, contact your doctor or pharmacist.

How should Sinequan be stored?

Sinequan should be stored at room temperature, between 15 and 30 degrees C (59 and 86 degrees F), in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Sinequan out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor.

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