Myambutol (Mynah, Etibi, Dexambutol, EMS-Fasol, Etambutyl, Etapiam, Miambutol, Mycobutol, Tibutolo, Afimocil, Anvital, Cidanbutol, Etambin, Farmabutol, Fimbutol, Inagen, Tisiobutol)
Generic name: Ethambutol
Brand names: Mynah, Etibi, Dexambutol, EMS-Fasol, Etambutyl, Etapiam, Miambutol, Mycobutol, Tibutolo, Afimocil, Anvital, Cidanbutol, Etambin, Farmabutol, Fimbutol, Inagen, Tisiobutol
Dosage form:
Capsules, tablets, coated tablets.
How does the drug work?:
TB drugs; gets into actively growing mycobacterial cells, inhibiting the synthesis of RNA, affect cell metabolism, causes cessation of reproduction and death of bacteria. Active just against actively dividing cells. Suppresses the growth and multiplication of Mycobacterium tuberculosis, resistant to ethionamide, Pasco, kanamycin, isoniazid, streptomycin. When monotherapy, the resistance of mycobacteria developes quite fastly.
Indications:
Tuberculosis (all forms).
Contraindications:
Hypersensitivity, pregnancy, children up to 13 years, cataract, optic neuritis, inflammatory eye diseases, gout, renal failure, lactation.
Side effects:
From the nervous system and sensory organs side:
hallucinations, depression, headache, weakness, disorientation, peripheral neuritis (paresthesias in the extremities, numbness, paresis, and itching), dizziness, altered mental status, optic neuritis (decrease in visual acuity, breach of color perception, mostly green and red colors, color blindness, scotoma).
From the digestive system:
loss of appetite, nausea, stomachodynia, vomiting, abnormal liver function – increase in the activity of “liver” of transaminases.
Allergic reaction:
itching, arthralgia, skin rash, fever, dermatitis, anaphylaxis.
Other:
hyperuricaemia, exacerbation podagry.
Overdose:
Symptoms:
Treatment:
symptomatic.
How to use the medicine? Dosage:
Inside.
When conducting initial medication – 15 mg / kg 1 time a day. In the conduct of re-treatment – 25 mg / kg 1 time a day for 2 months, then move on to 15 mg / kg 1 time a day.
Children – 20-25 mg / kg once, after breakfast.
The maximum daily dose – 2 g. In renal failure, the dose is adjusted depending on QA: QA with more than 100 ml / min, daily dose – 20 mg / kg, 70-100 ml / min – 15 mg / kg, less than 70 ml / min – 10 mg / kg, in people who are on hemodialysis, – 5 mg / kg, on day of dialysis – 7 mg / kg.
Cautions:
At the beginning of treatment may be increased cough, increase in sputum. Assigned just in combination with other anti-LS. When conducting long-term therapy must regularly monitor the function of the organ of vision, a picture of the peripheral blood, as well as the functional state of the liver and kidneys. During the period of treatment you must pay attantion while driving vehicles and occupation of other potentially hazardous activities that require high concentration of attention and quickness of psychomotor reactions.
Interaction:
Increases the effects of anti-LS, neurotoxicity of imipenem, ciprofloxacin, carbamazepine, methotrexate, quinine, asparaginase, aminoglycosides, salts of Li +.
Where to keep the drug?:
To keep in dark place.
Warning: Before starting take the drug, you need to consult your doctor.
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