Imodium by binding with opioid receptors of the intestinal wall (stimulation of choline-and adrenergic neurons through guanine nucleotides) decreases the tone and motility of smooth muscles of the intestine (due to inhibition of the release of acetylcholine and Pg). Slows the peristalsis and increases the time of passage of intestinal contents.


A specific inhibitor of H + – K + – ATPase (represses the activity of the enzyme, that accelerates the exchange of hydrogen ions). Acting in the final phase of secretion (separation) of hydrochloric acid in the stomach, the drug reduces the acid production, regardless of the nature of the stimulating factor. Duodenal ulcer exacerbation, reflyuksezofagit (inflammation of the esophagus caused by throwing gastric contents into the esophagus).


Zantac is the antiulcerogenic agent, that relates to a group of antagonists of histamine H2-receptors. It selectively blocks histamine H2-receptors of mucous coat of stomach and depresses excretion of hydrochloric acid. Antisecretory action of Zantac builds up auspicious conditions for healing of the stomach sore and duodenum sore.


Gastroprotective preparation that creates a protective pellicle, increases the synthesis of Pg, reduces the activity of pepsin and salt binds bile acids. Carafate dissolves in an acidic medium, forms a sticky paste-like polymer that has alkaline properties. Being in the stomach and duodenum 12, changes into a polyanion with a lot of free negative charges that form strong bonds with the positive radical of protein exudate (albumin, fibrinogen) mucosa.


Blocks peripheral and central (in the trigger zone of the brain) dopamine receptors, eliminates inhibitory effect of dopamine on the motor function of the digestive tract and increases the evacuation and the motor activity of the stomach. Has antiemetic effect, eliminates hiccup and nausea. Augments prolactin levels in serum.


Lowers the secretion of hydrochloric acid in the stomach, as an inhibitor of “proton pump”(process of the exchanging of hydrogen ions). The mechanism of antisecretory action associated with inhibition (suppression of) the enzyme H-K-ATPase (an enzyme that accelerates the exchange of hydrogen ions) in the cell membranes of the gastric mucosa, which leads to blocking of the final stage of formation of hydrochloric acid.