Generic name: Nabumeton Brand names: Arthaxan, Balmox, Consolan, Dolsinal, Flambate, Listran, Mebutan, Nabumetona, Nabumetonum, Nabuser, Prodac, Relif, Relifen, Relifex, Unimetone Pharmacology: Mode of action – anti-inflammatory, analgetic, antipyretic. The mechanism of action connected with the blockade of cyclooxygenase, which leads…
Anti-inflammatories
NSAIDs are very widely used in almost all the departments of medicine. By some estimates, each year in the world more than 60 million prescriptions of non-aspirin NSAIDs are being produced. However, the actual number of patients taking NSAIDs is much more, since this medication is approved for use as a non-prescription medicines.
The action of NSAIDs at the cellular level is associated with the inhibition of the enzyme cyclooxygenase-2 (COX-2), which leads to disruption of the synthesis of prostaglandins (PG) – proinflammatory cytokines.
Anti-inflammatory effect is manifested at weakening stage of exudation (edema) and proliferation (proliferation of connective tissue). Violation of PG synthesis leads to a decrease of the selection of biologically active substances that activate inflammation (histamine, serotonin), increase membrane permeability and increase swelling. Reduction of edema happens due to the normalization of the vascular permeability of membranes during inflammation. Important role in the anti-inflammatory effect of NSAIDs is played by their antioxidants whose main property is to inhibit lipid peroxidation (LPO), the products of which are the free radicals that damage biological membranestion, therefore contributing to the progression of inflammation.
NSAIDs have a broad spectrum of side effects, including the three major groups: NSAID-induced gastropathy, drug damaged articular cartilage, and cardiovascular complications. The greatest number of side effects is associated with disorders of the gastrointestinal tract. Minimal (but not eliminated) risk of side effects on the gastrointestinal tract is caused by preferential and selective COX-2 blockers, which requires a combination of them with a proton pump blockers (omeprazole and others).
Azulfidine
Generic name: Sulfasalazine Brand names: Sulfasalazine, Salicylazosulfapyridine, Salazosulfapyridine, Azulfidine (TN), Prestwick_848, Sulphasalazine, Sulfasalazine (USP/INN), Salazosulfapyridine (JP15) What is Azulfidine? Azulfidine – a drug with anti-microbial and anti-inflammatory properties. By its chemical structure is a combination of sulfapiridin and 5-aminosalitsil acid.…
Ponstel
Generic name: Mefenamic Acid Brand names: Ponstel General Information Ponstel belongs to a nonsteroidal anti-inflammatory medications. It is recommended to take in moderate pain as well as menstrual pain. You need to visit your doctor often if you take…
Indocin
Generic Name: Indomethacin (IN-doe-METH-a-sin) Brand names: Indocin General Information about Indocin. This drug belongs to a nonsteroidal anti-inflammatory medicines (NSAID). It is recommended to treat such symptoms as inflammation, pain and fever. This medication possesses the same effect as…
Ilosone
Generic name: Erythromycin Brand names: Eritrotsina, Ermitsin, Eriiin, Eritran, Eritrotsin, Etromitsin, Lubomiiin, Pantomitsinp, Tortrotsin, Eratsin, Ilozon, Eric, Meromitsin, Monomitsin, Erigeksal, Eritromen, Eritroped Pharmacological Effects: On the spectrum of antimicrobial effect it is similar to penicillin. The drug is active against…
Naprosyn
Generic Name: naproxen (na PROX en) Brand Names: Naprosyn, Leader Naproxen Sodium, Anaprox, Midol Extended Relief, Aleve, Naprelan What is Naprosyn usually prescribed for? Naprosyn is known as a nonsteroidal anti-inflammatory drug. It is used to relieve the stiffness,…
Asacol
Generic name: Aripiprazole Brand names: Aripiprazole, Abilitat, Arizol, Arlemide, Brisking, Ilimit, Irazem What is Asacol (mesalamine)? Asacol (mesalamine) is known as a popular delayed-release medicine. It curtails diarrhea, ulcerative colitis, proctosigmoiditis, signs of ulcerative colitis from recurring. Apprise your medic…
Aristocort
Generic name: Aristocort Brand names: Triamcinolone What is Aristocort (Triamcinolone)? Aristocort is used in treating of some medical conditions, such as insufficiency of the inflammatory disorders, adrenal cortex, allergic disorders and connective tissue disorders. Aristocort can also be prescribed…
Mobic
Generic name: Melox Brand names: Mobic, Movalis, Melox, Recoxa, Tenaron General information Mobic is considered to be a popular drug that is classified as NSAID. It is often recommended to treat fever, stiffness, osteoarthritis, pain, tenderness, inflammation, arthritis, dysmenorrhea.…
Feldene
Generic name: Piroxicam Brand names: Brexidol, Brexin, Erazon, Exipan, Felden, Feldoral, Hotemin, Pirox von ct, Proponol, Reumador, Tracam, Veral, Mobilis, Vurdon, Sinartrol, Roxam, Flamexin Pharmacological Effects: Has anti-inflammatory, analgesic and antipyretic effect. Inhibits synthesis of prostaglandins. Reduces pain, moderate-intensity. When…