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Analgesics

Analgesics and nonsteroidal anti-inflammatory drugs are used to reduce pain and eliminate inflammation. The path to the discovery of anesthetics was difficult and long. In the past, only folk remedies had been used for these purposes, and during the surgery the role of anesthetics was played by alcohol, opium, scopolamine, Indian hemp, and even such inhumane methods as stunning blow to the head or partial asphyxiation. In folk medicine to relieve pain and fever willow bark had long been used. Later it had been discovered that the active ingredient in willow bark was salicin, which is converted by hydrolysis into salicylic acid. Acetylsalicylic acid was synthesized as early as 1853, but it had not been used in medicine until 1899, until people found out about its effectiveness for arthritis and good endurance. Only after that the first drug of acetylsalicylic acid was introduced, which is now known worldwide as Aspirin. Since then, the number of synthesized compounds of different chemical nature, which suppress pain not causing the loss of consciousness, were discovered. These means are called analgesics (from the Greek algos – pain). Those that do not cause addiction, and in therapeutic doses do not inhibit the activity of the brain, are called non-narcotic analgesics. Since most of them additionaly have anti-inflammatory properties, they are called “Non-narcotic analgesics and nonsteroidal anti-inflammatory drugs.”

These substances are able to suppress the symptoms and signs of inflammation, including pain, because the reduction of the intensity of the inflammatory process leads to a decrease of pain. Furthermore, they reduce high body temperature, which means they have antipyretic effect, which is being exerted due to the thickening of skin vessels’ surface and strengthening of the heat emission.

The group of non-narcotic analgesics and nonsteroidal anti-inflammatory drugs are the drugs with different chemical structures and with different ratios of analgesic and anti-inflammatory effect. The mechanism of anti-inflammatory and analgesic action of NSAIDs is associated with inhibition of the enzyme specific – COX, contributing to the synthesis of prostaglandins – the major mediators of inflammation and pain. At the same time, they affect the synthesis and the transformation of other substances within the body (e.g. bradykinin) involved in the occurrence and distribution of inflammation and pain.

Relafen

January 11, 2019January 29, 2021 John BuducciAnalgesics, Anti-inflammatories, ArthritisLeave a Comment on Relafen

Generic name: Nabumeton Brand names: Arthaxan, Balmox, Consolan, Dolsinal, Flambate, Listran, Mebutan, Nabumetona, Nabumetonum, Nabuser, Prodac, Relif, Relifen, Relifex, Unimetone Pharmacology: Mode of action – anti-inflammatory, analgetic, antipyretic. The mechanism of action connected with the blockade of cyclooxygenase, which leads…

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Ponstel

January 5, 2019January 29, 2021 John BuducciAnalgesics, Anti-inflammatories, Arthritis, Womens healthLeave a Comment on Ponstel

Generic name: Mefenamic Acid Brand names: Ponstel   General Information Ponstel belongs to a nonsteroidal anti-inflammatory medications. It is recommended to take in moderate pain as well as menstrual pain. You need to visit your doctor often if you take…

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Indocin

January 4, 2019October 20, 2020 John BuducciAnalgesics, Anti-inflammatories, ArthritisLeave a Comment on Indocin

Generic Name: Indomethacin (IN-doe-METH-a-sin) Brand names: Indocin   General Information about Indocin. This drug belongs to a nonsteroidal anti-inflammatory medicines (NSAID). It is recommended to treat such symptoms as inflammation, pain and fever. This medication possesses the same effect as…

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Cymbalta

December 23, 2018October 22, 2020 John BuducciAnalgesics, AntidepressantsLeave a Comment on Cymbalta

Generic name: Cymbalta Brand names: Duloxetine, Cymbalta, Yentreve   General Information about Cymbalta. Cymbalta is a famous remedy which has been labeled as noradrenaline and serotonin reuptake inhibitor (SNRI), antidepressant. It diminishes symptoms of fibromyalgia, depression, generalized anxiety disorder (GAD)…

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Naprosyn

December 8, 2018October 25, 2020 John BuducciAnalgesics, Anti-inflammatories, ArthritisLeave a Comment on Naprosyn

Generic Name: naproxen (na PROX en) Brand Names: Naprosyn, Leader Naproxen Sodium, Anaprox, Midol Extended Relief, Aleve, Naprelan   What is Naprosyn usually prescribed for? Naprosyn is known as a nonsteroidal anti-inflammatory drug. It is used to relieve the stiffness,…

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Feldene

November 30, 2018October 25, 2020 John BuducciAnalgesics, Anti-inflammatories, ArthritisLeave a Comment on Feldene

Generic name: Piroxicam Brand names: Brexidol, Brexin, Erazon, Exipan, Felden, Feldoral, Hotemin, Pirox von ct, Proponol, Reumador, Tracam, Veral, Mobilis, Vurdon, Sinartrol, Roxam, Flamexin Pharmacological Effects: Has anti-inflammatory, analgesic and antipyretic effect. Inhibits synthesis of prostaglandins. Reduces pain, moderate-intensity. When…

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Arcoxia

November 29, 2018October 25, 2020 John BuducciAnalgesics, Anti-inflammatories, ArthritisLeave a Comment on Arcoxia

Generic name: Eroticoxib Brand names: Arcoxia, Nucoxia, Tauxib, Algix   How does it work? Arcoxia belongs to the type of drugs called NSAIDs. Selective COX-2 inhibitor, it is used to block the formation of prostaglandins. This remedy provides antipyretic, analgesic,…

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Tegretol

November 25, 2018October 25, 2020 John BuducciAnalgesics, Anticonvulsants, Neurological disordersLeave a Comment on Tegretol

Brand name: Tegretol Generic names: Calepsin, Biston, Epitol, Carbatrol, Finlepsin, Equetro, Sirtal, Telesmin, Stazepine, Timonil, Teril, Trimonil, Carbama/Carbamaze, Epimaz, Hermolepsin, Amizepin, Degranol, Tegretol XR, Carbamazepine   General Information Tegretol is considered to be a famous remedy which belongs to anticonvulsants.…

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Pyridium

November 25, 2018October 25, 2020 John BuducciAnalgesics, Urinary tractLeave a Comment on Pyridium

Generic name: Phenazopyridine Brand names: Pyridium   Pyridium Information: Pyridium is prescribed to relief pain. It is taken to stop the burning, pain or discomfort which is caused by irritation or infection of the urinary tract. This remedy is not…

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Nimotop

November 20, 2018October 26, 2020 John BuducciAnalgesics, Cardiovascular diseasesLeave a Comment on Nimotop

Generic name: Nimodipine Brand names: Nimotop   General Informaion about Nimotop Nimotop decreases problems associated with bleeding in the brain (subarachnoid hemorrhage-SAH). Nimotop belongs to a group of remedies known calcium channel blockers. Our organism reacts to bleeding by narrowing…

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