Hyzaar (Losartan-Hydrochlorothiazide)

Hyzaar
4.86 ratingsReviews
Generic:
Losartan-Hydrochlorothiazide
Indications:
hypertension stroke
Analogs:
Cozaar Diovan Hct Avalide Atacand Hct Micardis Hct Benicar Hct Zestoretic Vaseretic Lotensin Hct Amlodipine Chlorthalidone
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Hyzaar 12.5mg+12.5mg

Quantity Price per tablet You save Total price
30 £0.84 - £25.19
60 £0.68 £9.63 £40.74
90 £0.68 £14.08 £61.49
120 £0.61 £27.41 £73.34
180 £0.57 £48.89 £102.23
360 £0.48 £130.38 £171.87

Hyzaar 25mg+12.5mg

Quantity Price per tablet You save Total price
30 £0.49 - £14.82
60 £0.46 £2.22 £27.41
90 £0.40 £8.15 £36.30
120 £0.38 £13.33 £45.93

Hyzaar 50mg+12.5mg

Quantity Price per tablet You save Total price
30 £1.78 - £53.34
60 £1.52 £15.56 £91.12
90 £1.43 £31.11 £128.90
120 £1.39 £46.67 £166.68
180 £1.35 £76.30 £243.72
270 £1.33 £120.75 £359.29
360 £1.32 £165.20 £474.85

Manufacturers

ApotexBiogaranCipla LimitedOrganonOrganon CanadaOrganon FranceOrganon HealthcareOrganon ItaliaOrganon SaludUnichem Laboratories Ltd.

Payment & Delivery

Package Example

Your order is securely packed and usually dispatched within 24 hours. Here is what a typical parcel looks like.

It is about the size of a regular letter (24x11x0.7 cm) and does not show any details of what is inside.

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Delivery Times
Delivery MethodEstimated delivery
Express Free for orders over £222.24Estimated delivery to the UK: 4-7 days
Standard Free for orders over £148.16Estimated delivery to the UK: 14-21 days
EMSRoyal Mail
Payment Methods
VisaMastercardAmerican ExpressJCBBitcoin, USDTApple PayGoogle PayPayPalKlarnaClearpay

Discount Coupons

  • New Year's Day - 1 January 2026 9% NEWYEAR9
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  • Boxing Day - 26 December 2026 10% BOXING10
  • New Year's Eve - 31 December 2026 8% NYE8

Brand Names

Also known as (by country):
CountryBrand Names
United Kingdom
Cozaar-Comp
Australia
Cozaar Comp
Canada
Apo-Losartan/HCTZ

FAQ

Losartan-hydrochlorothiazide is a prescription-only medicine when obtained from local UK pharmacies. However, our store policy allows you to place an order without a prescription and have it sent by mail. A clinician should assess whether this treatment is appropriate for you.

Contact the clinician managing your blood pressure promptly if pregnancy is suspected or confirmed. Losartan-hydrochlorothiazide is contraindicated in the second and third trimesters because it can seriously harm the developing baby; it is also not recommended in early pregnancy. A clinician will need to arrange a suitable alternative treatment.

Not necessarily. Tablets with losartan-hydrochlorothiazide may differ from a familiar brand in colour, shape, size, markings and packaging. The exact appearance and imprint of the supplied product cannot be confirmed in advance, so compare the active ingredients, strength and dosage form on the label.

Store the film-coated tablets at 25°C; temporary excursions from 15°C to 30°C are permitted. Keep the container tightly closed and protect it from light. Keep the medicine out of the sight and reach of children.

Take this medicine by mouth, usually once daily, exactly as prescribed. The film-coated tablet can generally be taken with or without food and should be swallowed with water. Because hydrochlorothiazide is a diuretic, taking it earlier in the day may be more convenient if increased urination affects sleep; the strength and dose schedule should be selected individually.

Losartan-hydrochlorothiazide is used to treat essential hypertension in adults, particularly when blood pressure is not adequately controlled with losartan or hydrochlorothiazide alone. It combines an angiotensin II receptor blocker with a thiazide diuretic.

Description

Introduction

The medication Hyzaar is used to treat hypertension. This medication is a mixture of two drugs: a thiazide "water pill"/diuretic and an angiotensin receptor blocker. Blood vessels enlarge and relax when using Hyzaar. By increasing the volume of urine produced, the thiazide diuretic reduces the amount of extra water and salt in your body. Maintaining blood pressure control can help prevent kidney issues, heart attacks, and strokes.

Your doctor may prescribe this medication for other reasons. If you would like additional information on this medication, contact your doctor.

Even if your condition seems to be improving, don't stop taking Hyzaar earlier than your doctor has instructed. If you stop taking the drug too soon, it could make things worse. Until you know how this drug affects you, take caution when operating machinery, driving, climbing, or performing other risky actions. Avoid consuming alcohol. Never provide Hyzaar to a child without first consulting a physician.

How Should I Use Hyzaar?

Note: Don't give this medication to anyone else. Please take it as prescribed by your doctor, neither more nor less.

Hyzaar is administered orally with food, milk, or an antacid to avoid stomach upset. Unless your doctor instructs you otherwise, you may also take it with a full glass of water. Avoid lying down for half an hour after taking this medication. Administer the dosages regularly.

Excessive or Missed Dose

Any medication used in excess might have adverse effects on your health. Get in touch with your healthcare provider right away if you suspect an overdose.

If you forget to take a dose, take it as soon as possible. Never take two doses at once if your next dose is almost due. Take one dosage at a time.

Which Medical Issues or Symptoms Should I Notify a Doctor About Before Using Hyzaar?

Consult a physician if any of the following apply to you or have previously affected you:

  • allergies or asthma;
  • lupus;
  • an allergy to sulfa medications;
  • liver or kidney problems;
  • gout;
  • low or high blood potassium levels;
  • congestive cardiac dysfunction;
  • diabetes.

Adverse Effects

If you have any of the following severe side effects, get in touch with your doctor right away:

  • allergy symptoms such as a skin rash, lips, tongue, and facial swelling, hives, itching, and breathing difficulties;
  • reduced or absent urination, as opposed to increasing urination;
  • quick increase in weight;
  • fainting and swelling;
  • pale complexion, dizziness, pounding or rapid heartbeat, and elevated heart rate;
  • confusion;
  • sleepiness, easy bruising or bleeding, dry mouth, increased thirst, jaundice (yellowing of the skin or eyes), convulsions, or a restless feeling.

Less severe adverse effects:

  • skin rash;
  • sore throat;
  • dry cough;
  • backache;
  • nausea and dizziness;
  • stuffy or runny nose.

Other adverse effects could occur; this is not an exhaustive list. Tell your doctors about all the side effects you encounter.

Warning

Try not to get too hot or dehydrated when exercising in hot weather. Speak with your doctor to determine how much liquids you should consume daily. Unless advised otherwise by your doctor, stay away from potassium supplements and salt replacements while undergoing therapy. If taken during the latter six months of pregnancy, this medication has the potential to damage or even kill the fetus. See your doctor right away if you become pregnant or suspect you might be pregnant. Avoid abrupt standing or sitting up, particularly if you are an elderly patient. Regularly check your blood pressure. Tests for your renal function can also be necessary.

This page does not aim to cover all the information about Hyzaar, including safety measures, medication interactions, side effects, usage, recommendations, allergic reactions, or warnings.

How to Store

Hyzaar needs to be kept in a firmly closed container at room temperature. Keep out of the light, heat, and moisture. Store away from sinks and bathrooms. Hyzaar should be kept out of children's reach and away from animals.

Medically reviewed by
John Buducci
Pharmacology expert
Updated 11 August 2026

Customer questions

Asked by Emma Collins, Reading, United Kingdom

I'm in Reading and this pack looks different from my previous order. What should I check before I start taking it?

Answered by Support team

A different appearance alone does not mean the tablets are wrong. Compare the active ingredient, strength, dosage form, manufacturer, package label, lot number and expiry date; also compare the tablet imprint if one is present. Do not use the tablets until any mismatch in ingredient, strength, form, seal or condition has been checked.

Asked by James Patel, Birmingham, United Kingdom

I live in Birmingham. Can I check whether this medicine can be delivered to my postcode before I place the order?

Answered by Support team

Yes. Enter your Birmingham delivery address and postcode during checkout to see the delivery options available for that destination. Availability is confirmed from the options shown for the address rather than assumed in advance.

Asked by Adam F, Newry, United Kingdom

I'm in Newry, Northern Ireland. Can I confirm delivery to my address before I pay?

Answered by Support team

Yes. Please enter your Newry address and postcode at checkout to check the delivery options offered for your destination before payment. Delivery availability for Northern Ireland should be confirmed from those checkout options.

Asked by Daniel Wright, Stoke-on-Trent, United Kingdom

My order to Stoke-on-Trent has been marked as dispatched. Does that mean it will arrive tomorrow?

Answered by Support team

Not necessarily. Dispatch means the order has been sent, whereas delivery depends on the delivery service and the destination. The dispatch update does not confirm an arrival date.

Asked by Oliver Bennett, Belfast, United Kingdom

I have had gout attacks before and am considering this treatment for high blood pressure. Could it make gout worse?

Answered by Support team
Medical reviewed by John Buducci

It can be relevant: hydrochlorothiazide may increase uric acid levels and can contribute to gout attacks in some people. Tell the clinician choosing your blood-pressure treatment about your gout history so they can consider this alongside your current medicines and uric acid control.

Product specifications

Active ingredientLosartan-hydrochlorothiazide
Drug classAngiotensin II receptor blocker (ARB) with thiazide diuretic
Dosage formFilm-coated tablet
Available strengths50 mg/12.5 mg, 100 mg/12.5 mg, 100 mg/25 mg
RouteOral
StorageStore at 25°C; excursions permitted to 15°C to 30°C. Keep the container tightly closed and protect from light.
ATC codeC09DA01

Regulatory information

United Kingdom: medicine status
Prescription statusLosartan with hydrochlorothiazide is a prescription-only medicine in the United Kingdom.
Product registrationThe listed name and listed strengths do not by themselves confirm a current UK marketing authorisation for this exact Hyzaar product; UK authorisation must be checked for the specific brand, strength and tablet presentation.
NHS availabilityWhere prescribed and clinically appropriate, treatment may be supplied through the NHS; standard NHS prescription charges and exemption rules may apply in England.
Safety monitoringSuspected side effects should be reported through the MHRA Yellow Card Scheme.
Patient medicine informationNHS guidance is available for losartan, one of the active ingredients in this combination product.

More information