Antidepressants
Antidepressants are a broad therapeutic group rather than one single type of medicine. They include medicines that act on different brain signalling systems and may be prescribed for depression or other approved indications. The right medicine, strength and formulation should be selected with an authorised prescriber; products with different active ingredients are not automatically interchangeable.
What types of antidepressant should you understand before choosing?
Established antidepressant groups include selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs), tetracyclic antidepressants and tricyclic antidepressants. "Long-established" usually describes classes such as tricyclics, while SNRIs are a newer class in comparison; this does not make one approach universally more suitable than another. Prescribers consider the diagnosis, previous treatment, other medicines and the individual product's licensed information when deciding between them.
What is the UK position on these medicines?
Duloxetine, paroxetine and mirtazapine are prescription-only medicines in the United Kingdom. The exact Paxil CR name and prolonged-release presentation have not been confirmed as a UK-authorised product, even though paroxetine itself is a prescription-only medicine. For Sinequan capsules, a current UK authorisation and product classification have not been confirmed. These regulatory points concern the specific products and should not be treated as a statement about every antidepressant.
Which antidepressants do we list and how can they be compared?
We list Cymbalta, Paxil CR, Remeron and Sinequan. The comparison below highlights different active ingredients, oral forms and strengths in three of these listings; it is intended to support a discussion of the prescribed product rather than to suggest direct substitution.
| Product | Active ingredient | Form | Available strengths | Price from | Lowest price per tablet |
|---|---|---|---|---|---|
| Cymbalta | Duloxetine | Delayed-release capsules | 20 mg, 30 mg, 40 mg, 60 mg | £52.60 | £0.79 per tablet |
| Paxil CR | Paroxetine | Extended-release tablet | 10 mg, 20 mg, 30 mg, 40 mg | £55.56 | £0.73 per tablet |
| Remeron | Mirtazapine | Tablet | 7.5 mg, 15 mg, 30 mg | £55.56 | £0.99 per tablet |
Our range also includes Sinequan doxepin capsules in 10 mg, 25 mg and 75 mg strengths. Across the category, we show pack quantities from 30 to 360 tablets; the commercial tablet unit is used for price comparison, including for products supplied as capsules.
How do storage requirements affect delivery?
The listed products have differing storage instructions. Cymbalta and Remeron are stored at 25°C with permitted excursions between 15°C and 30°C, with protection from moisture; Remeron also requires protection from light. Paxil CR and Sinequan are stored at 20°C to 25°C, with permitted excursions between 15°C and 30°C; both require a tightly closed container, and Sinequan should be protected from light. We prepare every shipment carefully to protect the contents during delivery. Bring the parcel inside promptly and store each medicine as directed on its label.
We can dispatch these listed products to the United Kingdom by tracked Express delivery, estimated at 4-7 days, or Standard delivery, estimated at 14-21 days without tracking. Express shipping costs £22.22 and Standard shipping costs £11.10. Free shipping is available for either method when its respective checkout threshold is reached.
What should you check before ordering?
Confirm the medicine name, active ingredient, strength, formulation and pack quantity against your prescription before adding an item to your basket. We accept Visa, Mastercard, American Express, JCB, Bitcoin and USDT. If you need clarification about an order, product selection should remain guided by your prescriber and the product information for the exact medicine.