Azulfidine (Sulfasalazine)

Azulfidine
4.73 ratingsReviews
Generic:
Sulfasalazine
Indications:
ulcerative colitis
Analogs:
Salazopyrin Mesalamine Balsalazide Olsalazine Methotrexate Hydroxychloroquine Leflunomide Asacol Pentasa Lialda Plaquenil Arava Colazal Dipentum
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Azulfidine 500 mg

Quantity Price per tablet You save Total price
60 £1.53 - £91.86
90 £1.37 £14.08 £123.71
120 £1.30 £28.15 £155.57
180 £1.19 £61.49 £214.09
270 £1.14 £105.93 £307.43

Manufacturers

AlphapharmIpca Laboratories Ltd.Pfizer

Payment & Delivery

Package Example

Your order is securely packed and usually dispatched within 24 hours. Here is what a typical parcel looks like.

It is about the size of a regular letter (24x11x0.7 cm) and does not show any details of what is inside.

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Delivery Times
Delivery MethodEstimated delivery
Express Free for orders over £222.24Estimated delivery to the UK: 4-7 days
Standard Free for orders over £148.16Estimated delivery to the UK: 14-21 days
EMSRoyal Mail
Payment Methods
VisaMastercardAmerican ExpressJCBBitcoin, USDTApple PayGoogle PayPayPalKlarnaClearpay

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Brand Names

Also known as (by country):
CountryBrand Names
United Kingdom
Salazopyrin Salazopyrin EN-Tabs
Australia
Pyralin EN Salazopyrin
New Zealand
Salazopyrin
Canada
Salazopyrin

FAQ

Sulfasalazine is a prescription-only medicine when obtained from local pharmacies in the United Kingdom. However, our store policy allows Azulfidine 500 mg tablets to be ordered without a prescription and sent by mail. Medical supervision remains important because treatment may require blood-test monitoring.

These are oral sulfasalazine 500 mg tablets. Do not crush, chew or split them unless a pharmacist or prescriber has confirmed that this is appropriate for the particular tablets supplied. If swallowing tablets is difficult, ask a pharmacist or prescriber about a suitable alternative presentation or swallowing advice.

The exact manufacturer of the supplied product is not confirmed in advance and may vary with stock. Check the manufacturer's name on the received outer carton or container, together with the active ingredient, 500 mg strength, tablet form, batch number and expiry date.

Sulfasalazine may be used during pregnancy when clinically needed, but it can reduce folate absorption, so folic acid supplementation and treatment review are important. It passes into breast milk in small amounts; breastfeeding may be possible with caution, but the infant should be monitored for diarrhoea or blood in the stools. Extra care is needed for premature infants and infants with G6PD deficiency.

Description

General Information

Azulfidine is a medication that has anti-inflammatory and anti-microbial qualities. It is a mixture of 5-aminosalicylic acid and sulfapiridin. The medication is absorbed in small amounts from the colon's lumen and then evenly distributed within the connective tissue. Because Azulfidine is more readily absorbed (up to 30% of the dose), it primarily has a broad anti-inflammatory effect.

According to the National Library of Medicine, Azulfidine is prescribed for the following conditions:

  1. Rheumatoid arthritis.
  2. Polyarticular Juvenile Idiopathic Arthritis.
  3. Ulcerative colitis.

There are also non-FDA approved (off-label) indications:

  • Ankylosing Spondylitis;
  • Crohn's Disease;
  • Psoriatic Arthritis.

See your physician before using the medication.

How to Take

Azulfidine is given with 240-250 ml of drinking water, preferably before meals.

azulfidina-sulfasalazina-500mg-60grageas

Side Effects and Contraindications

Side effects frequently occur when the medication builds up a high concentration in the blood plasma. Patients with delayed occurrence of sulfapiridin acetylation rate may experience such a condition. Itchy skin, fever, headaches, gastrointestinal tract issues, and erythema are common adverse effects of the medication.

Restrictions

  • hypersensitivity to the medication's ingredients;
  • severe liver and kidney conditions;
  • up to two years of age.

Period of Pregnancy and Nursing

Pregnancy-related use of Azulfidine is permitted, but only in extreme cases. Expectant mothers are advised to select the lowest effective dosage. Breastfeeding is discontinued if medication is required because it is well excreted in breast milk.

Interactions

Digoxin and folic acid are less absorbed when taking Azulfidine, which strengthens the anticoagulant agents.

Please keep Azulfidine at a temperature of no more than 25°C in a dark place.

 

Medically reviewed by
John Buducci
Pharmacology expert
Updated 11 August 2026

Customer questions

Asked by Oliver, Manchester, United Kingdom

I'm in Manchester and my order now says it has been dispatched. Does that mean my tablets will arrive tomorrow?

Answered by Support team

Not necessarily. Dispatch means the order has left for delivery, while arrival depends on the delivery service and route. Please check the delivery information for the applicable delivery estimate.

Asked by Sophie, Nottingham, United Kingdom

I live in Nottingham. Can I check whether Azulfidine can be delivered to my postcode before I place the order?

Answered by Support team

Yes. Enter your Nottingham postcode in the delivery options at checkout to see the destinations available for the order before payment. Availability can vary by address.

Asked by Aoife, Belfast, United Kingdom

I'm in Belfast. Can I confirm delivery to my address before I pay for the tablets?

Answered by Support team

Yes. Use your Belfast postcode and address in the checkout delivery options before payment to check whether this product can be delivered there. We cannot confirm regional availability until the destination is entered.

Asked by Harriet, Portsmouth, United Kingdom

I'm in Portsmouth and concerned about tablets being handled in transit. Can sulfasalazine tablets normally travel safely by mail?

Answered by Support team

Tablets can normally be sent by mail when properly packed and kept in their protective container. After arrival, check that the container is intact and dry, then store the tablets at 20°C to 25°C, away from moisture. Do not use them if the packaging or tablets appear damaged.

Product specifications

Active ingredientSulfasalazine
Drug classAminosalicylate anti-inflammatory
Dosage formTablet
Available strengths500 mg
RouteOral
StorageStore at 20°C to 25°C; excursions permitted from 15°C to 30°C. Keep the container tightly closed and away from moisture.
ATC codeA07EC01

Regulatory information

United Kingdom: medicine status
Registration statusAzulfidine 500 mg tablets are not confirmed as a current UK-authorised presentation from the available official records; Salazopyrin and other sulfasalazine products must not be treated as evidence of registration for this exact product.
Prescription statusSulfasalazine is a prescription-only medicine in the United Kingdom.
NHS medicine informationThe NHS provides patient information on sulfasalazine, including its uses, how to take it and important precautions.Safety monitoringRegular blood tests may be required during sulfasalazine treatment; suspected side effects can be reported through the UK Yellow Card scheme.

More information