Antidepressants
Antidepressants are a family of prescription medicines used in depression care and, depending on the medicine, may also be prescribed for other mental health conditions. Choosing within the class is a discussion for the prescriber and patient: active ingredient, medicine class, release type, strength, and the prescribed regimen all matter.
What types of antidepressants should customers understand before choosing?
Selective serotonin reuptake inhibitors (SSRIs) are a widely used, long-established group that includes fluoxetine, paroxetine, and sertraline. Other established approaches include serotonin-norepinephrine reuptake inhibitors (SNRIs), such as duloxetine, tricyclic antidepressants such as doxepin, and tetracyclic antidepressants such as mirtazapine. "Long-established" refers to classes with a lengthy history in clinical practice, not to a recommendation that one medicine is right for every person.
Which antidepressant approaches are established for human use in the United States?
SSRIs, SNRIs, tricyclic antidepressants, and tetracyclic antidepressants are established antidepressant approaches in US prescribing practice. For the named active ingredients in the comparison below - mirtazapine, paroxetine, doxepin, and fluoxetine - human use is authorized in the United States. The listed forms of these products require a prescription. This does not establish registration of any particular product name, package, or strength.
Which antidepressants do we list, and how can they be compared?
We list six antidepressants in this category: Cymbalta, Paxil CR, Prozac, Remeron, Sinequan, and Zoloft. The comparison highlights four products with differing active ingredients and dosage forms; they are not interchangeable. Use your prescription to match the medicine, form, and strength selected.
| Product | Active ingredient | Form | Confirmed strengths | Price from | Lowest price per catalog unit |
|---|---|---|---|---|---|
| Remeron | Mirtazapine | Tablet | 7.5 mg, 15 mg, 30 mg | $46.50 | $0.99 per tablet |
| Paxil CR | Paroxetine | Extended-release tablet | 12.5 mg, 25 mg, 37.5 mg | $43.50 | $0.60 per tablet |
| Sinequan | Doxepin | Capsules | 10 mg, 25 mg, 75 mg | $52.70 | $0.27 per tablet |
| Prozac | Fluoxetine | Capsule | 10 mg, 20 mg, 40 mg, 60 mg | $31.90 | $0.33 per capsule |
Package quantities and sellable options vary by product. Review the product page and select only the option that matches your prescription; an extended-release tablet should not be treated as the same type of option as a standard capsule or tablet.
How do we ship antidepressant orders in the United States?
We can dispatch orders with Express shipping, which includes tracking and is estimated at 4-7 days for $29.99, or Standard shipping, estimated at 14-21 days for $14.99. Free shipping is available when an order reaches the applicable threshold shown at checkout. We accept Visa, Mastercard, American Express, Discover, Bitcoin, USDT, Apple Pay, and Google Pay.
What should customers consider when an order arrives?
We package orders carefully for ordinary postal delivery. Please collect your order promptly after arrival and follow the product's labeled storage instructions. For example, Remeron is stored at 77°F, with permitted excursions from 59°F to 86°F, in a tightly closed container protected from light and moisture; Paxil CR is stored between 68°F and 77°F in its original tightly closed container away from moisture. One verified Remeron customer noted that the outside of the package did not advertise its contents.