Antidepressants
What are antidepressants, and how do their types differ?
Antidepressants are a broad family of prescription medicines used in mental health care. They include long-established tricyclic and tetracyclic medicines as well as newer classes such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). These class names describe different pharmacological approaches, so medicines with different active ingredients should not be treated as interchangeable.
Before choosing an option, customers should confirm the prescribed active ingredient, strength, and release type. An extended-release tablet or delayed-release capsule is not simply the same as an immediate-release oral medicine, even when related medicines have similar names.
Which antidepressant approaches are used in the United States?
SSRIs and SNRIs are widely used modern antidepressant classes in U.S. prescribing, while tricyclic and tetracyclic antidepressants remain established options in selected clinical circumstances. Within the products we list, paroxetine is an SSRI, duloxetine is an SNRI, mirtazapine is a tetracyclic antidepressant, and doxepin is a tricyclic antidepressant.
Each listed medicine is prescription-only in the United States. Cymbalta delayed-release capsules and Paxil CR extended-release tablets have FDA listings for those specific products. Mirtazapine is an FDA-approved prescription antidepressant, while the historical U.S. branded Sinequan capsule product was discontinued; that history does not establish current U.S. market availability for the brand.
Which antidepressants do we list, and what can customers compare?
We list four oral antidepressant products across four active ingredients. The comparison below focuses on formulation, available strengths, and catalog pricing rather than suggesting that one medicine can replace another.
| Product | Active ingredient | Form | Available strengths | Price from | Lowest price per tablet |
|---|---|---|---|---|---|
| Cymbalta | Duloxetine | Delayed-release capsules | 20 mg, 30 mg, 40 mg, 60 mg | $71.00 | $1.07 per tablet |
| Paxil CR | Paroxetine | Extended-release tablet | 10 mg, 20 mg, 30 mg, 40 mg | $75.00 | $0.99 per tablet |
| Remeron | Mirtazapine | Tablet | 7.5 mg, 15 mg, 30 mg | $75.00 | $1.34 per tablet |
| Sinequan | Doxepin | Capsules | 10 mg, 25 mg, 75 mg | $86.00 | $0.89 per tablet |
Package quantities and prices vary by product and strength. We show the applicable options on each product page so you can match your order to the prescription you have received.
What should I check before ordering a prescribed antidepressant?
Check that the product name, active ingredient, strength, and dosage form match your prescription. This is especially important for modified-release forms: Paxil CR is an extended-release tablet, and Cymbalta is supplied as delayed-release capsules. If a prescription, product name, or formulation is unclear, ask the prescribing clinician or pharmacist before placing an order.
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How do shipping and storage considerations affect an order?
We ship to U.S. customers by Express shipping with tracking, estimated at 4-7 days, or Standard shipping, estimated at 14-21 days. Express shipping costs $29.99 and Standard shipping costs $14.99. Free shipping is available for either method when its respective checkout threshold is reached.
These medicines have product-specific storage directions. Cymbalta is stored at 77°F, with permitted excursions from 59°F to 86°F, and should be protected from moisture. Paxil CR is stored between 68°F and 77°F in its original tightly closed container away from moisture. Remeron is stored at 77°F, with excursions from 59°F to 86°F, and protected from light and moisture; Sinequan is stored at 68°F to 77°F, with brief excursions from 59°F to 86°F, and protected from light. We package medicines carefully for ordinary shipping. Prompt receipt and correct storage after delivery help keep the order in good condition. Review the labeled storage information when your order arrives.