Sinequan (Doxepin)

Sinequan
4.726 ratingsReviews
Generic:
Doxepin
Indications:
agitation anxiety depression sleepiness
Analogs:
Amitriptyline Imipramine Nortriptyline Sertraline Escitalopram Fluoxetine Paroxetine Venlafaxine Duloxetine Mirtazapine Trazodone Buspirone Silenor Elavil Pamelor Tofranil Desipramine Norpramin Clomipramine Anafranil Remeron Zoloft Lexapro Prozac Effexor Cymbalta
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Sinequan 10 mg

Quantity Price per tablet You save Total price
180 $0.98 - $176.00
360 $0.89 $31.00 $321.00

Sinequan 25 mg

Quantity Price per tablet You save Total price
30 $2.87 - $86.00
60 $2.13 $44.00 $128.00
90 $1.90 $87.00 $171.00
120 $1.80 $128.00 $216.00
180 $1.68 $213.00 $303.00
270 $1.61 $338.00 $436.00
360 $1.58 $464.00 $568.00

Sinequan 75 mg

Quantity Price per tablet You save Total price
30 $3.20 - $96.00
60 $2.50 $42.00 $150.00
90 $2.26 $85.00 $203.00
180 $2.06 $205.00 $371.00
270 $1.99 $326.00 $538.00
360 $1.94 $452.00 $700.00

Manufacturers

Alphapharm Pty LtdCheplapharm Arzneimittel GmbHSolus Pharmacy

Payment & Shipping

Package Example

Your order is securely packed and usually ships within 24 hours. Below is what a standard package looks like.

It is about the size of a regular letter (9.4x4.3x0.3 inches) and shows no details about what is inside.

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
EMSUSPS
Payment Methods
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Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

Brand Names

Also known as (by country):
CountryBrand Names
Australia
Deptran
New Zealand
Anten

FAQ

Doxepin capsules require a prescription when purchased from local US pharmacies. However, our store policy allows you to order this medicine without a prescription and have it sent by mail. A clinician should still assess whether doxepin is appropriate before treatment begins.

Doxepin can cause drowsiness, dizziness, blurred vision, and slower reactions. Do not drive, operate machinery, or do other hazardous tasks until you know how the capsules affect you. Alcohol and other sedating medicines can worsen impairment.

The active ingredient in Sinequan is doxepin, and a generic medicine described as doxepin contains that same active ingredient. The supplied product is oral doxepin capsules available in 10 mg, 25 mg, and 75 mg strengths. Manufacturer, capsule appearance, and inactive ingredients can differ between products.

Store the capsules at 68°F to 77°F. Brief temperature excursions between 59°F and 86°F are permitted. Protect the container from light, keep it tightly closed, and keep it out of reach of children and pets.

Sinequan contains doxepin, a tricyclic antidepressant used for depression and anxiety. Doxepin can also have sedating effects, but the appropriate use and dose depend on the condition being treated and the specific formulation. These capsules should not be assumed to be suitable for every sleep problem or other symptom.

Sinequan capsules are taken by mouth on the schedule prescribed for the individual. Doxepin may be given in divided doses or as a single daily dose, often in the evening when sedation is a concern. Take only the prescribed strength and schedule, and do not change the dose on your own.

Description

What is Sinequan?

Sinequan is a popular medication that is known as a tetracyclic antidepressant. It is prescribed for the treatment of psychotic depressive disorders, depression, posttraumatic stress disorder (PTSD), and anxiety, including clues of fibromyalgia and chronic pain.

Sinequan, as a tricyclic antidepressant, should not be used with monoamine oxidase inhibiting drugs (MAOI) because high fever, convulsions, and even death may occur from such combinations.

Sinequan is not approved for use in children under 12. Always tell a healthcare professional before giving Sinequan to a child.

Your doctor may prescribe this remedy for other purposes. Contact your physician if you need to learn more information about this drug.

Don't stop treatment with Sinequan earlier than it was prescribed by your doctor, even if you notice improvements in your condition. Stopping the medication too early may worsen your condition. Be careful about doing dangerous tasks, driving, operating machinery, or climbing until you are aware of how this drug affects you.

What Symptoms or Conditions Should I Report to a Doctor Before I Take This Medicine?

It is important to report to a doctor if you have or have had the following conditions:

  •     heart disorders, heart attack, stroke, or high blood pressure;
  •     liver or kidney disease;
  •     an unusual or allergic reaction to doxepin, other medicines, foods, dyes, or preservatives;
  •     asthma;
  •     diabetes;
  •     enlarged prostate or difficulty urinating;
  •     stomach or intestinal problems;
  •     seizures or epilepsy;
  •     glaucoma;
  •     pregnancy, breastfeeding, or planning to become pregnant.
    Sinequan

How to Take Sinequan?

Note: This remedy was prescribed to you only. Do not share this medication with others. Follow strictly your doctor's prescription. Do not take more or longer than your doctor recommended.

This medicament is presented as capsules or liquid to be taken orally.

The recommended starting dose of this medicine is 25 mg. It is usually recommended to take the medicine 1 to 3 times daily, at around the same time(s) every day. Dosages above 500 mg per day are not recommended.

This medicine is usually accompanied by some liquid. To protect your kidneys, it is important to drink several glasses of water each day while you are taking Sinequan. You may take it on a full or empty stomach. Combining it with food is advisable to minimize stomach irritation and help your body absorb the drug.

The capsules should be swallowed whole. Do not crush, break, chew, or open them. Shake the suspension well before each use to mix the medication evenly. Use a specially marked measuring spoon or medicine cup to ensure the correct dose. Do not use this amount unless your healthcare provider specifically instructs you to do so.

What Should Be Done If I Missed the Dose?

In case you forgot to take the dose, take it at your earliest opportunity. Never double your dose if it is almost time for your next dose. Take only one dose at once.

Overdosage

Taking any medicine in large doses can have serious consequences for your health. If you are overdosed, visit your doctor straight away.

In large doses, Sinequan may cause coma, delirium, shock, or agitation.

Interactions

  •     Anticholinergic medications (Atropine, Belladonna, Clidinium, Dicyclomine, Glycopyrrolate);
  •     Arrhythmia medications (Amiodarone, Disopyramide, Flecainide, Propafenone);
  •     Cimetidine (Tagamet);
  •     Phenothiazine medications (Chlorpromazine, Trifluoperazine, Thioridazine);
  •     SSRI or SNRI medications (Citalopram, Escitalopram, Sertraline);
  •     Tolazamide (Tolinase);
  •     tricyclic antidepressants (Amitriptyline, Maprotiline, Trimipramine).

This list of interactions may not be complete. Provide your medical practitioner with an entire list of medicines, herbs, dietary supplements, or non-prescription drugs you take. Moreover, tell them whether you drink alcohol, use illegal drugs, or smoke. Particular items may interact with your drug.

Which Side Effects Can I Perceive from This Remedy?

  •     Allergic reaction (difficulty breathing; skin rash or swelling; swelling of your throat, lips, tongue or face; hives; itching).
  •     Loss of appetite.
  •     Weight changes.
  •     Fast/pounding/irregular heartbeat (palpitations).
  •     Mental mood changes (abnormal dreams, abnormal thinking, loss of contact with reality, restlessness, confusion, hallucinations, blurred vision).
  •     Problems with breathing and chest pain.
  •     Sore throat, chills, and fever.
  •     Numbness, tingling in your hands or feet (tremor), muscle stiffness, or spasms.
  •     Indigestion, upset stomach, bloating, stomach gas, pain, or cramps.
  •     Nausea, vomiting.
  •     Unusual bleeding or bruising.
  •     Headache, dizziness, ringing in your ears, or hearing loss.
  •     Difficulty urinating (urinary retention), diarrhea.
  •     Low blood pressure.
  •     Liver problems, yellowing eyes, skin.

If these persist or worsen, notify your doctor immediately. This is not a complete list of side effects, and others may occur. Contact your doctor or pharmacist if you have other reactions not mentioned above.

How Should Sinequan Be Stored?

Sinequan should be stored in a tightly closed container at room temperature, between 15 and 30 degrees C (59 and 86 degrees F). It should be protected from moisture, direct heat, and light. It should not be stored in the bathroom or near a sink. It should also be kept out of the reach of children and away from animals.

With regard to the treatment of several mental health issues, especially anxiety and depression, Sinequan is a significant improvement. The effectiveness of this medication in reducing symptoms, along with its low frequency of side effects, highlights its significance in contemporary mental health treatment. To achieve the best possible results and enhance the quality of life, patients and their healthcare providers must collaborate closely to develop the most suitable treatment plan, just like with any drug.

Medically reviewed by
John Buducci
Pharmacology Expert
Updated August 11, 2026

Customer questions

Asked by Megan Carter, Philadelphia, United States

I found doxepin capsules at another online store for almost half the price. Why should I order from you instead?

Answered by Support team

We stand behind the quality of the generic medicines we offer. We cannot verify what another seller supplies, how it is sourced or handled, or whether a lower-priced offer is truly equivalent in manufacturer, origin, and product quality. The choice is yours, but it is worth deciding whether the savings justify accepting that unknown.

Asked by Daniel Martinez, Houston, United States

My Sinequan package arrived with a broken seal. Can I still take the capsules?

Answered by Support team

Do not use capsules from a package with a broken seal or other signs that its protection may have been compromised. Keep the package and contact customer service within 7 days of delivery so the issue can be reviewed and a replacement or refund can be arranged.

Asked by Jordan Lee, Denver, United States

My doctor has me on escitalopram, and I am considering doxepin for anxiety and sleep. Can the two medicines be taken together?

Answered by Support team
Medical reviewed by Wendy Hayes

Doxepin and escitalopram can have additive effects on serotonin and may also increase drowsiness. This combination sometimes requires individualized review because of the risk of serotonin toxicity, heart-rhythm effects, and greater sedation; a prescriber should assess your medicines and medical history before they are used together.

Product specifications

Active ingredientDoxepin
Drug classTricyclic antidepressant
Dosage formCapsules
Available strengths10 mg, 25 mg, 75 mg
RouteOral
StorageStore at 68°F to 77°F; brief excursions permitted between 59°F and 86°F. Protect from light and keep the container tightly closed.
ATC codeN06AA12

Regulatory information

United States: Sinequan medicine status
Registration statusSinequan (doxepin hydrochloride) capsules were previously FDA-approved in the United States but have been discontinued; this does not confirm current availability of the branded product.
Prescription statusDoxepin capsules are prescription-only medicines in the United States.
Official labelingDailyMed publishes FDA-submitted labeling for currently marketed U.S. doxepin products; verify the manufacturer, NDC, strength, and dosage form because this may not be branded Sinequan.
Safety monitoringSuspected serious adverse events and product-quality problems may be reported to the FDA MedWatch program.

More information