Prilosec (Omeprazole)

Prilosec
4.417 ratingsReviews
Generic:
Omeprazole
Indications:
gastroesophageal reflux disease heartburn ulcers Zollinger-Ellison syndrome
Analogs:
Nexium
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Prilosec 10 mg

Quantity Price per capsule You save Total price
90 $1.00 - $90.00
120 $0.93 $8.00 $112.00
180 $0.89 $20.00 $160.00
270 $0.86 $39.00 $231.00
360 $0.84 $59.00 $301.00

Prilosec 20 mg

Quantity Price per capsule You save Total price
60 $1.28 - $77.00
90 $1.10 $16.50 $99.00
120 $1.02 $32.00 $122.00
180 $0.94 $62.00 $169.00
270 $0.88 $108.50 $238.00
360 $0.85 $157.00 $305.00

Prilosec 40 mg

Quantity Price per capsule You save Total price
30 $2.90 - $87.00
60 $2.02 $53.00 $121.00
90 $1.76 $103.00 $158.00
120 $1.60 $156.00 $192.00
180 $1.45 $261.00 $261.00
270 $1.36 $415.00 $368.00
360 $1.32 $570.00 $474.00

Manufacturers

ApotexAstraZenecaDr. Reddy's Laboratories Ltd.HexalLaboratorios CinfaMalesci Istituto FarmacobiologicoRanbaxy Laboratories Ltd.ratiopharm

Payment & Shipping

Package Example

Your order is securely packed and usually ships within 24 hours. Below is what a standard package looks like.

It is about the size of a regular letter (9.4x4.3x0.3 inches) and shows no details about what is inside.

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Back View
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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
EMSUSPS
Payment Methods
VisaMastercardAmerican ExpressDiscoverBitcoin, USDTApple PayGoogle PayPayPal

Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

Brand Names

Also known as (by country):
CountryBrand Names
United Kingdom
Losec
Canada
APO-Omeprazole Losec
Australia
Losec
New Zealand
Losec Omezol

FAQ

In the United States, Prilosec delayed-release capsules are prescription medicines when purchased from local pharmacies. Our store policy allows you to place an order without a prescription and have the medicine sent by mail. This ordering policy does not change the medicine's prescription status in the United States.

Do not use a capsule if its blister, seal, or other protective packaging is damaged or opened and the medicine's integrity is uncertain. Keep the package and arrange for the issue to be checked before taking the capsule.

Not necessarily. Products containing omeprazole may use different inactive ingredients, capsule shells, colors, or coatings depending on the manufacturer. Check the ingredient list on the package you receive if you have an allergy, intolerance, or dietary restriction.

Store the capsules at 68°F to 77°F in a tightly closed container, protected from light and moisture. Keep them in their labeled packaging until use and out of reach of children and pets.

Take omeprazole delayed-release capsules by mouth before a meal, usually 30 to 60 minutes beforehand. Swallow the capsule whole; do not crush or chew it because the delayed-release granules protect the medicine from stomach acid. The appropriate dose and treatment duration depend on the condition being treated.

Common side effects include headache, stomach pain, nausea, diarrhea, constipation, and gas. Seek prompt medical attention for signs of a serious allergic reaction, severe or persistent diarrhea, unusual weakness or muscle cramps, or a new severe rash. Longer-term use may require clinical review because proton pump inhibitors can affect nutrient absorption and carry other risks in some people.

Description

A proton pump inhibitor called Prilosec reduces the quantity of acid the stomach produces. Prilosec is used to treat problems brought on by an excess of stomach acid, such as symptoms of gastroesophageal reflux disease (GERD). Additionally, omeprazole, the active ingredient of Prilosec, is used to aid in the recovery of erosive esophagitis, which is an acid reflux disease that damages the esophagus.

When treating a gastrointestinal ulcer brought on by a Helicobacter pylori infection, Prilosec may also be administered in addition to antibiotics.

Over-the-counter Prilosec can manage heartburn that happens two or more days a week. Prilosec OTC is to be taken as a regimen for a consecutive 14 days.

How Does It Work?

Prilosec suppresses the stomach's production of hydrochloric acid by acting as an inhibitor of the "proton pump"-the mechanism that exchanges hydrogen ions. The mechanism of antisecretory activity is linked to the inhibition (suppression) of the gastric mucosa cell membranes' H-K-ATPase enzyme, which speeds up the exchange of hydrogen ions and blocks the last step of hydrochloric acid generation. Consequently, independent of the stimulus type, it lowers the basal (own) level and stimulates secretion (secretion of digestive juices).

Your doctor may prescribe this medication for different reasons. If you would like additional information on this medication, contact your doctor.

Even if you see improvements in your health, don't stop taking Prilosec earlier than your doctor has suggested. If you stop taking the drug too soon, it could make things worse. Until you know how this drug affects you, take caution when operating machinery, driving, climbing, or performing other risky actions. Avoid consuming alcohol.

Prilosec14tabs

Before Treatment 

Early signs of a heart attack can be confused with heartburn. If you feel dizzy or overheated and your chest pain radiates to your shoulder or jaw, get emergency medical attention.

Use of Prilosec is not advised in the following cases:

  • if you have an omeprazole allergy or if you have an allergy to medications that are similar to omeprazole, including Protonix, Nexium, Prevacid, Lansoprazole, Pantoprazole, and Rabeprazole; 
  • you've previously taken omeprazole and experienced respiratory issues, renal issues, or a severe allergic reaction; 
  • you use rilpivirine-containing HIV medications (Complia, Edurant, Odefsey, Juluca). 

Find out from a physician or pharmacist if using this medication is safe if you have the following: 

  • difficulty or pain during swallowing;
  • black or bloody stools, vomit that resembles coffee grounds or blood; 
  • heartburn persisting for more than three months; 
  • regular heartburn and wheezing, chest pain; 
  • rapid weight loss; 
  • nausea, vomiting, and abdominal pain;
  • hepatic illness; 
  • inadequate blood magnesium levels; 
  • decreased bone mineral density, often known as osteoporosis (osteopenia). 

When using a proton pump inhibitor for an extended period or more than once a day, you run the risk of breaking a bone in your hip, wrist, or spine. Consult your physician about maintaining the health of your bones. 

Proton pump inhibitor (PPI) acid-suppressing medications, including omeprazole, have been linked to a higher risk of stomach cancer, commonly known as gastric cancer when used long-term. Based on the findings of multiple observational studies, it is believed that PPIs, like omeprazole, are strong gastric acid suppressants that may raise the risk of gastric cancer by thinning the stomach lining, increasing the hormone gastrin levels, and encouraging the growth of bacteria in the stomach.

Consult a physician before using this medication if you are nursing a baby or pregnant.

How Should Prilosec Be Taken? 

Adhere strictly to the label's instructions or your doctor's prescription when using Prilosec. Read all drug guides or instruction sheets and abide by all guidelines on the label of your medicine.

If you are unable to take the entire contents, open the capsule and sprinkle the medication into a spoonful of applesauce. Immediately swallow the mixture. Don't keep it for later.

The powdered Prilosec needs to be dissolved in a tiny amount of water. This combination can be administered with a catheter-tipped syringe via a nasogastric (NG) feeding tube or by swallowing it. 

Take OTC Prilosec no more than 14 days in a row. It could take one to four days for your symptoms to get better. Before you begin a fresh 14-day round of treatment, give yourself at least 4 months. 

If your symptoms worsen or do not improve, call your doctor. 

Antibiotics and Prilosec are used in conjunction to treat certain illnesses. Take all prescriptions exactly as prescribed.

This medication may influence certain medical test results. Inform every medical professional you see that you take Prilosec. 

Prilosec42tabs

Adverse Effects of Prilosec

If you have any of the following symptoms of a Prilosec allergic reaction: hives, trouble breathing, or swelling in your face, lips, tongue, or throat, get emergency medical attention.

Call your doctor and cease taking Prilosec if you have: 

  • acute stomach ache, bloody or watery diarrhea; 
  • unexpected or fresh back, hip, thigh, or wrist pain; 
  • seizure (fits and fits); 
  • kidney problems: fever, rash, nausea, appetite loss, joint discomfort, decreased frequency of urination, blood in the urine, weight gain;
  • low magnesium - jitteriness, cramps, spasms in the muscles, feeling like you're choking, or experiencing dizziness;
  • joint pain and a skin rash on your face or arms that worsens in the sun are new or worsening signs of lupus.

Long-term Prilosec use may increase the risk of fundic gland polyps, which are growths in your stomach. Discuss this risk with your physician. 

Over three years of omeprazole use may result in vitamin B-12 insufficiency. If you have this illness, consult your physician about how to treat it. 

Typical Prilosec adverse effects could be: 

  • signs of a cold, including stuffy nose, sneezing, and sore throat (particularly in kids); 
  • fever, particularly in young people; 
  • gas and stomach ache; 
  • vomiting, diarrhea, and nausea; 
  • headache. 

Other adverse effects might also arise; this is not an exhaustive list. For medical advice regarding side effects, contact your physician. 

Which Other Medications Will Impact Prilosec?

There are situations when taking certain drugs with Prilosec is unsafe. Certain drugs can alter the blood levels of other medications you take, which could worsen side effects or reduce their efficacy. 

Inform your physician about every medication you are taking. Omeprazole interacts with several medications, particularly: 

  • digoxin;
  • clopidogrel;
  • methotrexate;
  • St John's Wort;
  • a "water pill" or diuretic;
  • an antibiotic (rifampin, clarithromycin, or amoxicillin). 

Numerous additional medications may interact with omeprazole; this list is not exhaustive. 

Medically reviewed by
John Buducci
Pharmacology Expert
Updated August 11, 2026

Customer questions

Asked by Danielle Carter, Charlotte, United States

Before I order, can you tell me how much shelf life the capsules will have left?

Answered by Support team

We cannot guarantee a specific remaining shelf-life period before an order is received. Check the expiration date printed on the medicine package when it arrives, and do not use capsules after that date.

Asked by Marcus Reed, Nashville, United States

My order just arrived. Where do I confirm that I received the omeprazole strength I selected?

Answered by Support team

Check the package label for the active ingredient, omeprazole, the strength in mg, and the dosage form, delayed-release capsule. Also compare the manufacturer name, lot number, expiration date, and any capsule imprint if present; do not use it if the ingredient, strength, or dosage form appears wrong.

Asked by Emily Nguyen, Seattle, United States

I am in Seattle and am concerned about moisture during transit. Can delayed-release omeprazole capsules normally travel by mail?

Answered by Support team

Yes, delayed-release capsules can normally be mailed when they are appropriately protected from moisture, light, and physical damage. For a Seattle shipment, inspect the package and capsules on arrival and follow the labeled storage conditions of 68°F to 77°F; transit temperature and duration can vary.

Asked by Robert Martinez, San Jose, United States

How is this type of capsule protected during transportation to San Jose?

Answered by Support team

Delayed-release capsules need protection from light, moisture, and crushing during ordinary transport. For an order going to San Jose, check that the package is intact and the capsules are dry and undamaged on arrival; if the packaging is compromised, do not use the medicine until the issue is checked.

Asked by Jordan Williams, Phoenix, United States

I take a prescribed amphetamine medication for ADHD. Can omeprazole affect it?

Answered by Support team
Medical reviewed by Mildred Torres

Omeprazole can increase amphetamine absorption and may raise the chance of stimulant side effects in some people. Your prescriber or pharmacist should review the combination, especially if you notice increased jitteriness, insomnia, a fast heartbeat, or anxiety.

Product specifications

Active ingredientOmeprazole
Drug classProton pump inhibitor
Dosage formDelayed-release capsule
Available strengths10 mg, 20 mg, 40 mg
RouteOral
StorageStore at 68°F to 77°F in a tightly closed container, protected from light and moisture.
ATC codeA02BC01

Regulatory information

United States: Prilosec medicine status
FDA approvalPrilosec delayed-release capsules containing omeprazole in 10 mg, 20 mg, and 40 mg strengths are approved in the United States under NDA 019810.
Prescription statusPrilosec delayed-release capsules are prescription-only medicines in the United States.
NDA applicantAstraZeneca Pharmaceuticals LP is the applicant listed for FDA NDA 019810 for Prilosec delayed-release capsules.
Medicare coverageMedicare Part D coverage and patient cost for prescription omeprazole products vary by plan and formulary; CMS does not provide a single nationwide coverage determination for Prilosec.
Adverse event reportingSuspected serious adverse events and product-quality problems may be reported to the FDA through MedWatch.

More information