Estrace (Estradiol)

Estrace
4.78 ratingsReviews
Generic:
Estradiol
Indications:
breast cancer menopause osteoporosis
Analogs:
Estradiol Climara Vivelle Dot Minivelle Alora Divigel Estrogel Vagifem Imvexxy Estring Femring Premarin Prempro Activella Duavee Angeliq Osphena Intrarosa Veozah Brisdelle Menest
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Estrace 1 mg

Quantity Price per tablet You save Total price
60 $1.93 - $116.00
90 $1.73 $18.00 $156.00
120 $1.66 $33.00 $199.00
180 $1.57 $65.00 $283.00
270 $1.50 $116.00 $406.00
360 $1.48 $164.00 $532.00

Estrace 2 mg

Quantity Price per tablet You save Total price
30 $3.07 - $92.00
60 $2.40 $40.00 $144.00
90 $2.17 $81.00 $195.00
120 $2.07 $120.00 $248.00
180 $1.95 $201.00 $351.00
270 $1.89 $319.00 $509.00
360 $1.85 $439.00 $665.00

Manufacturers

BayerGerman RemediesNovo NordiskSanofiSearchlight PharmaTeva PharmaceuticalsTheramexViatris

Payment & Shipping

Package Example

Your order is securely packed and usually ships within 24 hours. Below is what a standard package looks like.

It is about the size of a regular letter (9.4x4.3x0.3 inches) and shows no details about what is inside.

Front View
Front View
Side View
Side View
Back View
Back View
Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
EMSUSPS
Payment Methods
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Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

Brand Names

Also known as (by country):
CountryBrand Names
United Kingdom
Elleste Solo Progynova Zumenon
Australia
Estrofem Progynova
New Zealand
Aerodiol Climara Estraderm Estring Estrofem Femtran Progynova Sandrena Vagifem

FAQ

Estradiol tablets require a prescription when purchased from local US pharmacies. Our store policy allows Estrace to be ordered without a prescription and sent by mail. A clinician should still evaluate whether systemic estrogen treatment is appropriate.

Store Estrace tablets at 68°F to 77°F. Brief temperature excursions from 59°F to 86°F are permitted. Keep the container tightly closed and away from moisture and out of reach of children and pets.

A generic described as estradiol contains estradiol, the active ingredient in Estrace. The available tablets are oral estradiol tablets in 1 mg and 2 mg strengths. The manufacturer, tablet appearance, package, and inactive ingredients may differ.

A different appearance does not by itself mean the tablets are incorrect. Compare the package label for estradiol, the prescribed strength, oral tablet dosage form, manufacturer, lot number, and expiration date; also compare the tablet imprint when one is present. Do not use the tablets if the ingredient, strength, form, imprint, seal, or physical condition appears wrong or compromised.

This product is available as oral tablets containing 1 mg or 2 mg of estradiol. The appropriate strength depends on the indication and the treatment plan selected for the individual.

Estrace is an oral estradiol tablet that should be swallowed as directed, preferably at a consistent time each day. It may generally be taken with or without food. Dose and schedule vary by indication, so the prescribed regimen should be followed rather than using a dose intended for another condition or person.

Estrace tablets are contraindicated during known or suspected pregnancy and should not be used in pregnancy. During breastfeeding, estradiol requires caution because estrogens can pass into breast milk and may reduce milk quantity and quality. The benefits and alternatives should be reviewed with the clinician managing postpartum care.

Estrace provides estradiol, an estrogen used for conditions related to low estrogen. Uses can include moderate to severe menopausal hot flashes, vulvar and vaginal atrophy, estrogen deficiency from hypogonadism or ovarian failure, and prevention of postmenopausal osteoporosis when appropriate. Estradiol may also be used for selected palliative cancer indications under specialist care.

Description

There are various kinds of estrogens in the natural world. The female hormone estrogen is required for numerous bodily functions. In females, the daily production of estradiol by the ovaries can range from 70 to 500 micrograms. Estrone and, to a lesser extent, estriol are produced from this. Estrone is the most active circulating estrogen after menopause. Women's sex organs expand because of estrogens, which also affect sex traits, including pubic and underarm hair, skeleton, and body shapes. Moreover, estrogens promote the formation of the endometrium, the uterine lining, and cervical secretions.

The blood levels of LDL cholesterol (the "bad" cholesterol) are lowered, and estrogens increase HDL cholesterol (the "good" cholesterol). One kind of estrogen is estradiol. Estradiol is advised for the treatment of menopausal symptoms (hot flashes, dry vagina, etc.), heart attack and stroke prevention, osteoporosis-related bone fracture prevention, and dysfunctional (excessive and painful) uterine hemorrhage. It is even possible to prescribe estradiol to treat cancer in both men and women. In women who are unable to manufacture adequate estrogen, it functions by substituting natural estrogens. It acts by opposing male hormones in cases of advanced prostate cancer. Your doctor may prescribe Estrace for any other uses not mentioned above.

What Information Is Necessary Before Taking Estrace?

Estrace shouldn't be taken if you have:

  • issues with circulation and a history of stroke;
  • any kind of cancer that is hormone-dependent, uterine, or breast;
  • unusual vaginal bleeding for which your doctor has not examined hemorrhage or blood-clotting disorders;
  • notify a physician if you have liver or renal illness;
  • migraines, depression, asthma, high blood pressure, angina, triglycerides, cholesterol, seizures, epilepsy, and gallbladder disease;
  • diabetes;
  • if you've had a hysterectomy or removal of your uterus.

When using Estrace, make sure to visit your doctor regularly and check your breasts for lumps once a month. The use of estrace raises the possibility of endometrial hyperplasia. Uterine carcinoma may result from this illness. Progesterone use in conjunction with Estrace may reduce this risk. Your risk of stroke may rise if you receive long-term Estrace treatment. See your doctor before taking Estrace consistently. Your medical assistant should assess your progress every three to six months to see if you should continue receiving this treatment. FDA pregnancy category X. Pregnancy should not involve estrogens because of the higher risk of fetal defects. If you are nursing a baby, avoid taking estrogens.

How Is Estrace Supposed to Be Used?

Indication Dosage Administration
Moderate to severe vasomotor symptoms, vulval and vaginal atrophy associated with menopause 1 to 2 mg daily, adjusted to control symptoms Cyclic administration: 3 weeks on, 1 week off
Female hypoestrogenism due to hypogonadism, castration, or primary ovarian failure 1 to 2 mg daily, adjusted to control symptoms Titrate for maintenance therapy
Breast cancer (palliation only, metastatic disease) 10 mg three times daily for at least three months -
Advanced androgen-dependent carcinoma of the prostate (palliation only) 1 to 2 mg three times daily Judge effectiveness by phosphatase levels, symptomatic improvement
Prevention of osteoporosis Consider for women at significant risk, lowest effective dose not determined -

Take Estrace exactly as prescribed by your physician. Don't ever adjust the dosage. You should take this medication with a full glass of water. To lessen stomach problems, you can take Estrace with food or after a meal.

Take the dosage as soon as possible if you forget to take it. Never take two doses at once if your next dose is almost due. Take one dosage at a time.

Any medication used in excess might have adverse effects on your health. Get in touch with your doctor if you suspect an overdose. When taken in excess, this medication may result in nausea, vomiting, and vaginal bleeding.

Which Adverse Effects of this Medication Should I Know About?

Estrace has the same potential adverse effects as any medication. However, the majority of users don't have any adverse effects. In most cases, side effects are readily handled or don't even need to be addressed.

Typical, less dangerous side effects:

  1. Hair loss.
  2. Abnormal vaginal bleeding or spotting and retention of fluid.
  3. Elevated blood pressure.
  4. Headaches.
  5. Nausea and vomiting.
  6. Breast sensitivity.
  7. Yeast infections in the vagina.
  8. Stomach pains or bloating in the abdomen.
  9. Elevated glucose levels (hyperglycemia).
  10. Growth of uterine fibroids, benign tumors of the uterus.

The following is a list of uncommon but more dangerous adverse effects:

  1. Heart attacks.
  2. Strokes related to dementia.
  3. Hypersensitivity responses.
  4. Gallbladder illness.
  5. Clots of blood.
  6. Cancer of the breast, uterus, or ovaries.

Which Other Drugs Interact With Estrace?

Estrace can interact with other medications. The following medications have the potential to interact with Estrace: 

  • Barbiturates, such as phenobarbital (Luminal®), amobarbital (Amytal®), secobarbital (Seconal®), butalbital (Fioricet®, Fiorinal®), and pentobarbital (Nembutal®).
  • Some antibiotics or antifungal medications, like Itraconazole (Sporanox®), Miconazole, Rythromycin (Ery-Tab®), Elithromycin (Ketek®), Clarithromycin (Biaxin®), ketoconazole (Nizoral®), and isoniazid (Nydrazid®).
  • Some anti-seizure drugs, like carbamazepine (Carbatrol®, Epitol®, EquetroTM, Tegretol®), phenytoin (Dilantin®, Phenytek®), and oxcarbazepine (Trileptal®) Cyclosporine (Sandimmune®, Neoral®, and Gengraf®).
  • Grapefruit juice.
  • Liothyronine (Cytomel®), Levothyroxine (Levoxyl®, Synthroid®, Unithroid®), Liotrix (Thyrolar®), Thyroid (Armor® Thyroid, Nature-Throid®), Fosamprenavir (Lexiva®), Ritonavir (Norvir®), Indinavir (Crixivan®), Nelfinavir (Viracept®), Atazanavir (Reyataz®), and Amprenavir (Agenerase®) are examples of hypothyroidism (underactive thyroid) medications. 
  • St. John's wort (Hypericum perforatum) and rifamycin antibiotics, such as rifapentine (Priftin®), rifampin (Rifadin®), and rifabutin (Mycobutin®)

It's possible that this list of interactions is incomplete. Give your doctor a complete list of all the medications, herbal remedies, nutritional supplements, and over-the-counter medications you take. Additionally, let them know whether you smoke, take illegal substances, or drink alcohol. Certain things might interfere with your medication.

Store the cure at room temperature, in a covered container, between 15° (59°F) and 30°C (86°F). Keep it out of the reach of children and animals, as well as heat, moisture, and direct light. Avoid freezing.

Medically reviewed by
John Buducci
Pharmacology Expert
Updated August 11, 2026

Customer questions

Asked by Megan Carter, Columbus, United States

I live in Columbus and want to order the 1 mg tablets. Can I find out whether you ship to my ZIP code before placing the order?

Answered by Support team

Yes. Enter your Columbus ZIP code during checkout to check whether this product can be shipped to your address. Availability is confirmed there rather than assumed for every ZIP code.

Asked by Melissa P, Jacksonville, United States

My Estrace package was left outside in Jacksonville heat for several hours. Is it still okay to take?

Answered by Support team

Because the actual temperature and duration of exposure are unknown, do not assume the tablets were unaffected. Keep the package, check the container and tablets for damage or unusual changes, and compare the label with the storage requirement of 68°F to 77°F before using it.

Asked by Lauren Mitchell, Dallas, United States

Before I order, how can I tell how many Estrace tablets are in the package?

Answered by Support team

Select the package quantity shown with the product before adding it to your order. Available package options are 30, 60, 90, 120, 180, 270, and 360 tablets.

Asked by Robert Jenkins, Fort Worth, United States

Are estradiol tablets the kind of medicine that can handle normal mail transportation?

Answered by Support team

As solid oral tablets, they can normally travel by mail when packed to prevent crushing and moisture exposure and handled according to the labeled storage conditions. On arrival, check that the container is intact, tightly closed, and that the tablets show no damage or unusual appearance.

Asked by Erica Nguyen, Seattle, United States

I take tizanidine for muscle spasms. Can I start these estradiol tablets without changing anything?

Answered by Support team
Medical reviewed by Spencer Hughes

Estradiol can increase tizanidine concentrations, which may increase effects such as drowsiness, dizziness, or low blood pressure. The prescriber managing your tizanidine should review the combination before estradiol is started.

Product specifications

Active ingredientEstradiol
Drug classEstrogen
Dosage formTablet
Available strengths1 mg, 2 mg
RouteOral
StorageStore at 68°F to 77°F; brief excursions permitted between 59°F and 86°F. Keep the container tightly closed.
ATC codeG03CA03

Regulatory information

United States: medicine status
Registration statusEstradiol tablets in 1 mg and 2 mg strengths are FDA-approved prescription drug products; the listed name "Alora" does not establish registration of this pill product under that name.
Prescription statusEstradiol tablets are available in the United States by prescription only.
Safety monitoringSuspected serious adverse events and product-quality problems may be reported to the FDA MedWatch program.

More information