Rocatrol (Calcijex, Decostriol)
Generic name: Calcitriol
Brand names: Calcijex, Decostriol
What is Rocartol?
Rocatrol is one of the most important active metabolite of vitamin D3. Normally, the body produces 0.5-1 mg / day, during the intense development of bones (growth or pregnancy) – a few more. Calcitriol has more pharmacological activity than vitamin D3. Increases absorption of Ca2 + and phosphate in the intestine and reabsorption in the proximal tubules of the kidney, inhibits the secretion of parathyroid hormone, thus regulating bone mineralization and stimulating the activity of osteoblasts (promoting their differentiation), participates in the maintenance of the neuromuscular transmission in the functioning of striated muscle, modulates the immune reaction.
It decreases pain in the bones and muscles, but also eliminates the histological changes that occur when the fibrous osteitis. In patients with post-surgical and idiopathic gipoparatireozom and psevdogipoparatireozom reduces hypocalcaemia and its clinical manifestations. In patients with vitamin-D-dependent rickets concentration calcitriol in the serum is low or completely absent (given the lack of endogenous synthesis of calcitriol in the kidneys, its reception can be considered in such patients as a replacement treatment).
Osteodystrophy of renal origin (in people with renal insufficiency, including on the background of dialysis), vitamin D-dependent rickets, hypocalcemia on the background gipoparatireoza (including postoperative and idiopathic), tetany (including postoperative, idiopathic), osteoporosis (postmenopauzny, senile and “steroid”), familial hypophosphataemia against the vitamin D – resistant rickets (congenital phosphate diabetes).
Hypersensitivity, hypercalcaemia, renal osteodystrophy with hyperphosphatemia. Atherosclerosis, CHF, CRF sarcoidosis or other granulomatosis, hyperphosphatemia, phosphate nefrourolitiaz, old age (may contribute to the development of atherosclerosis), pregnancy, children’s age, lactation, pulmonary tuberculosis (active form).
Symptoms of hypervitaminosis of vitamin D (may be the when taking therapeutic doses, depending on individual sensitivity to the drug:
- early (due to hypercalcemia) – anorexia, vomiting, hypercalciuria, hypercalcaemia, polyuria, headache, constipation or diarrhea, asthenia, dryness of the oral mucosa, thamuria, thirst, unusual fatigue, metallic taste the mouth, nausea, nocturia;
- later – drowsiness, clouding of urine (appearance in the urine hyaline cylinders, proteinuria, leukocyturia), pancreatitis, conjunctival hyperemia, itching, stomachalgia, nausea, weight loss, bone pain, arrhythmia, increased blood pressure, vomiting, photosensitivity of the eyes, myalgia, rarely – mental changes (up to the development of psychosis) and mood.
Inside, the initial daily dose is 0.25 mg. If clinical indicators do not become better within 2-4 weeks of treatment, daily dose is increased by 0.25 mcg to medium (0.5-1 mg / day) and above, at intervals of 2-4 weeks. High doses of calcitriol needs to be divided into 2-3 reception.
When menopausal osteoporosis – 0.25 mg 2 times a day. In renal osteodystrophy adults – to 0.25-3 mg per day. When gipoparatireoze and rachitis: adults – 0.25-2.7 mg / day (morning), children – 0.01-0.1 mg / kg / day to 1 mg / day for vitamin D-dependent rickets and 0.04-0.08 mg / kg / day for gipoparatireoze.
When a family hypophosphataemia – 2 mg / day. When hypocalcemia in people who are the hemodialysis patients: adults – 0.5-3 mg / day or more; children – to 0.25-2 mg / day.
Increases the toxicity of cardiac glycosides and increases the risk of arrhythmias caused by the development of hypercalcemia. Incompatible with vitamin D and its derivatives (increases the risk of hypervitaminosis D).
Where to store the medicine?
In a dry place with temperature under 30 C.
Warning: Before using the medicine you need to consult your doctor.
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