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Last updated on November 22nd, 2021

Generic name: Nalidixic Acid

Brand names: Neggram

General Information:

NegGram cures infections of urinary tract which were caused by certain bacteria. NegGram belongs to antibacterial drugs. It stops the production of proteins which are necessary for the bacteria’s survival and in this way it is killing sensitive bacteria in the urinary tract. NegGram works only against bacteria; it does not treat viral infections as well as flu or cold.

Contact your physician if you need to learn more information about this drug.

Don’t stop treatment with NegGram earlier than it was prescribed by your doctor even if you notice improvements of your condition. Stopping the medication too early may worsen your condition. Be careful about doing dangerous tasks, driving, operating machinery or climbing until you are aware how this drug affects you. Don’t drink alcohol. Always contact a medic before giving NegGram to a child.

You should not take NegGram if you have or had the following conditions:

  • take an antiarrhythmic for abnormal heartbeat procainamide, quinidine, sotalol or amiodarone
  • if you may have allergy to any component in NegGram
  • if you are taking cancer chemotherapy with the melphalan medicine or related medicines
  • if you have history of convulsions
  • if you have the blood disease or porphyria

What symptoms or conditions should I report to a doctor before I take this medicine?

It is important to report to a doctor if you have or had the following conditions:

  •     you are planning to become pregnant, pregnant, or are breast-feeding
  •     you are taking any herbal preparation, prescription or nonprescription medicine, or dietary supplement
  •     you have allergies to foods, medicines, or other substances
  •     you have a central nervous system disease, Alzheimer disease, increased pressure in your brain, hardening of the arteries in your brain, sensitivity to the sun, kidney or liver problems, or a family history of heartbeat problems.

Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug. Tell your doctor if you take any of the following: Antiarrhythmics (eg, procainamide, quinidine, sotalol, amiodarone), melphalan, cyclosporine, theophylline, certain medicines that affect heartbeat (eg, amitriptyline, erythromycin, cisapride) or anticoagulants (eg, warfarin) since NegGram may increase the risk of their side effects. NegGram may also decrease the effectiveness of Probenecid.

This list of interactions may be not complete. Inquire your medical practitioner whether NegGram may interact with other medicines you take.

How do I take this medicine?

Note: This remedy was prescribed to you only. Do not share this medicament with others. Follow the prescriptions of your physician.

Take NegGram with food or without it. In order to reduce risk of problems with stomach, take it with food. Don’t use products that contain magnesium (quinapril), calcium, zinc, sucralfate, and aluminum or iron preparations within 2 to 3 hours of taking NegGram. These products may bind with the medicine preventing its absorption. Drink a full glass of water every time you take the remedy. Also it is important to drink some extra glasses of water each day to protect your kidneys, unless otherwise is recommended by your doctor. Do not use caffeine during treatment with NegGram.

What should I do if I miss the dose?

If you miss the dose, try to take it as soon as you have the opportunity. If it is time for your next dose, take only one dose. You don’t have to double the dose.

What should you do if you overdose of NegGram?

Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.



NegGram may cause blurred vision, dizziness, and drowsiness. Don’t drink alcohol. NegGram may make your skin tenderer to becoming sunburned. Avoid the sun, sunlamps, or tanning booths until you know what your reaction to NegGram is. Wear protective clothing or try to limit your outside staying.

Mild diarrhea is common side effect of this remedy. Though, pseudomembranous colitis, a more serious form of diarrhea may happen in some cases. Consult your physician at once.

Repeated or long-term or use may lead to another infection. Contact your physician in case you notice the symptoms of other infection.

Diabetes patients – NegGram may cause the results of some tests for urine glucose to be wrong. Contact your doctor before you make changes to your diet or the dose of your diabetes medication.

Be prepared!  To check your condition your doctor may advise you some tests, including liver function, and complete blood cell counts.

Pregnancy and Breast-Feeding: If you are pregnant, consult your physician about the benefits and risks of using NegGram during pregnancy. Do not breast-feed while taking NegGram.

Which side effects can I perceive from this remedy?

Most people have no, or minor side effects. Contact your doctor if any of the following side effects persist or become bothersome:

vomiting, rash

Side effects that you should make known to your medical practitioner as quickly as possible:

numbness; rash; tightness in the chest; weakness; burning or tingling sensation; swelling of the mouth, tongue, lips or face; blurred or decreased vision; seeing halos around lights; itching; hives; itching; pain, redness, or swelling of a tendon; convulsions; double vision; body position; decrease in ability to feel pain; difficulty breathing; changes in color vision; pain; temperature.

NegGram should be stored at room temperature, between 15 and 30 degrees C (59 and 86 degrees F), in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep NegGram out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor.

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