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Last updated on: November 22nd, 2021

Generic name: Valacyclovir

Brand names: Valtrex, Valaciclovir Hydrochloride, Valaciclovir Hcl, Valacyclover Hydrochloride, Valacyclover Hydrochloric, Valacyclovir, Valacyclovir Hydrochloride

How does it work?

Valtrex is a specific inhibitor of DNA polymerase of herpes viruses. It blocks the synthesis of viral DNA and viral replication. In the human’s body it turns into acyclovir and valine; as a result of phosphorylation of acyclovir it is formed an active acyclovir triphosphate, which competitively inhibits viral DNA polymerase. The first step of phosphorylation occurs under the effect of virus-specific enzyme (for herpes simplex virus, varicella zoster, Epstein-Barr – virus thymidine kinase, which is found only in cells infected with the virus).

Valtrex is prescribed by doctors to cure shingles; prevention of recurrence of disease caused by herpes simplex virus; mucous and skin membranes caused by the herpes simplex (including genital herpes);  prevention of cytomegalovirus infection on the background of immunodeficiency (organ transplantation, HIV infection,  and bone marrow chemotherapy, cancer, etc.).

How to take the drug?

Note: This remedy was prescribed to you only. Do not share this medicament with others. Follow strictly your doctor’s prescription. Do not take more or longer than your doctor recommended.

Take the remedy inside. To treat herpes zoster – 1 g 3 times a day during a week. To treat herpes simplex take 500 mg twice per day. In case your condition relapses caused by herpes simplex virus, the treatment begins in the prodromal period or immediately after the first symptoms within 5 days, if needed, at the first stage of the medication, the duration is increased to 10 days.

The dosage may vary among individuals. It is obviously to contact your doctor before taking this medicament. Follow your physician’s instructions carefully.

What should I do if I miss the dose?

If you miss the dose, try to take it as soon as you have the opportunity. If it is time for your next dose, take only one dose. You don’t have to double the dose.



Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.


Hypersensitivity, children’s age, lactation, pregnancy.

Side effects:

Nausea, hemolytic anemia, renal insufficiency, headache, microangiopathy, thrombocytopenia (patients with severe immunodeficiency who received high-dose valaciclovir (8 g / day) and long time).

Drug Interactions:

Valtrex decreases the effect (blocking the conversion of acyclovir). Nephrotoxic medicines increase the risk of renal failure and CNS disorders.

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.


Valtrex should be stored at room temperature, between 15 and 30 degrees C (59 and 86 degrees F), in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Valtrex out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor. The information contained in this article is not intended to cover all possible precautions, drug interactions, adverse effects, directions, uses, allergic reactions or warnings.

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