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Last updated on: November 17th, 2021

Clozaril (Azaleptin, Leponex, Fazaclo, Froidir; Denzapine, Zaponex; Klozapol, Clopine)

Generic name: lozaril

Brand names: Azaleptin, Leponex, Fazaclo, Froidir; Denzapine, Zaponex; Klozapol, Clopine

What is Clozaril (Azaleptin, Leponex, Fazaclo, Froidir; Denzapine, Zaponex; Klozapol, Clopine)?

Clozaril is taken to remedy schizophrenia. This pharmaceutical is only taken when others have not worked. It has a risk of serious side effects and is only available through a monitoring and dispensing system that includes special pediatrician, and laboratories. For the first few months of treatment, you will be required to have routine blood testing before your prescription can be refilled. This pharmaceutical may be taken for other objective; ask your doctor if you have questions.

What should I report to my pediatrician before I take this pill?

They need to know if you have any of these conditions:

  • being treated for cancer
  • blood disease or disorder, like leukemia
  • constipation, fecal impaction, or a history of an obstruction of the intestine
  • dementia
  • diabetes
  • heart disease-kidney disease
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • lung or breathing disease, like asthma
  • Parkinson’s disease
  • seizures
  • an unusual or allergic reaction to clozapine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this pill?

Take this remedy by mouth with a drink of water. Follow the directions on the prescription label. This medicine may be used with or without food. Take your doses at regular intervals. Do not take your drug more often than directed. Do not suddenly stop using this pill. You may need to gradually reduce the dose. Stop taking this drug on the advice of your pediatrician only.

Talk to your pediatrician regarding the use of this pharmaceutical in children. Special medication may be needed.


If you think you have used too much of this drug contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this drug with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you miss your drug for more than 2 days, you should not restart your remedy at the same dose. Contact your health care provider for instructions.

What may interact with this remedy?

Do not use this remedy with any of the following:

  • cisapride
  • medicines for treating cancer
  • mibefradil
  • olanzapine
  • phenothiazines like perphenazine, thioridazine and chlorpromazine
  • pimozide
  • ziprasidone

This pharmaceutical may also interact with the following:

  • caffeine
  • carbamazepine
  • cimetidine
  • ciprofloxacin
  • erythromycin or clarithromycin
  • lithium
  • medicines for anxiety or sleeping problems, such as diazepam or temazepam
  • medicines for colds, hay fever, and other allergies
  • medicines for high blood pressure
  • medicines for mental depression, anxiety, or other mood problems
  • nicotine
  • phenytoin
  • rifampin or rifabutin
  • some medicines used to treat irregular heartbeats

This register may not report all possible interactions. Give your pediatrician a catalogue of all the pharmaceuticals, herbs, non-prescription remedies, or dietary supplements you take. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your pill.


What side effects may I notice from this pill?

Side effects that you should tell your physician as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in vision
  • chest pain, fast or irregular heartbeat
  • confusion
  • difficulty sleeping, nightmares
  • excessive thirst and/or hunger
  • feeling faint or lightheaded, falls
  • fever, chills, sore throat, or mouth sores
  • muscle and joint aches and pains
  • nausea, vomiting, or severe loss of appetite
  • restlessness
  • seizures
  • stiffness, spasms, trembling
  • trouble passing urine or change in the amount of urine
  • trouble with balance, talking, walking
  • uncontrollable tongue or chewing movements, smacking lips or puffing cheeks
  • unusually weak or tired
  • yellowing of the eyes, skin

Side effects that usually do not require medical attention ( report to your physician if they continue or are bothersome):

  • constipation
  • dry mouth
  • headache
  • increased watering of the mouth, drooling
  • weight gain

This catalogue may not report all possible side effects.

What should I watch for while using this specific?

Visit your health care provider for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Contact your doctor if your syndromes get worse or if you have new prodromes.

You must have a weekly blood test when you first begin this pill. If your blood counts stay in the right range, your tests may be abated after 6 months to every other week. Your name will go on a national registry of patients that take this pharmaceutical, to make sure that you have never had a serious reaction to it.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Do not heal yourself for colds, fever, diarrhea or allergies. Ask your doctor for advice, some nonprescription specific may increase possible side effects.

If you are going to have surgery speak to your doctor that you are using this pill.

Where should I store this pharmaceutical?

Store out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused remedies after the expiration date.

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