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Magnesium Trisilicate

Last updated on November 7th, 2023

Magnesium trisilicate may sound like a complex chemical compound, but its significance in medicine cannot be overstated. Let’s delve into the depths of this intriguing substance, uncovering its uses, how to take it, potential interactions, side effects, and essential guidelines for storage.
It may be given in typical oral doses of up to 500 mg as required, although higher doses have been given. When given orally, it reacts more slowly with hydrochloric acid in the stomach than magnesium hydroxide. Magnesium trisilicate is often given with aluminum-containing antacids such as aluminum hydroxide, which counteract its laxative effect. Magnesium trisilicate is also used as a food additive and a pharmaceutical excipient.

Magnesium Trisilicate

What Is Magnesium Trisilicate?

Magnesium trisilicate is a compound composed of magnesium, silicon, and oxygen. Its unique properties make it a valuable player in the pharmaceutical world. This white, odorless powder is known for its ability to neutralize excess stomach acid, relieving those grappling with heartburn and indigestion.

Uses of Magnesium Trisilicate

Antacid Powerhouse: The primary role of magnesium trisilicate is as an antacid. It works by reacting with stomach acid, forming water and harmless substances, effectively neutralizing the acidity. This makes it a go-to solution for managing heartburn and indigestion.

Gastrointestinal Shield: Additionally, magnesium trisilicate can act as a protective barrier in the stomach lining, relieving irritation caused by acidic contents.

How to Take

Magnesium trisilicate is commonly available in chewable tablets or suspensions. It’s crucial to follow your healthcare provider’s recommendations regarding dosage and frequency. Chewable tablets should be chewed thoroughly before swallowing, while suspensions need to be shaken well before use.


As with any medication, magnesium trisilicate can interact with other substances. It’s advisable to inform your healthcare provider about all the medications, supplements, or herbal products you are currently taking. Certain antibiotics, digoxin, and tetracycline, for instance, may be impacted by magnesium trisilicate.

Side Effects

While magnesium trisilicate is generally well-tolerated, some individuals may experience mild side effects such as diarrhea or stomach cramps. If these symptoms persist or worsen, seeking medical advice is essential. Allergic reactions are rare but can occur, and immediate medical attention should be sought if symptoms like rash, itching, or swelling occur.

Effects on the Kidneys

The formation of renal calculi containing silica is unusual but has been reported in a small number of patients. In most of these cases, stone formation was attributed to the prolonged, and sometimes excessive, intake of antacids that contained magnesium trisilicate.


Avoid exceeding the recommended dosage of magnesium trisilicate, as an overdose may lead to more severe side effects such as muscle weakness, difficulty breathing, or irregular heartbeat. If you suspect an overdose, seek emergency medical attention promptly.

How to Store

Proper storage is crucial to maintain the effectiveness of magnesium trisilicate. Keep it in a cool, dry place away from direct sunlight. Ensure the container is tightly closed, and do not store it in the bathroom where moisture levels can fluctuate.

In conclusion, magnesium trisilicate is a valuable ally in the battle against heartburn and indigestion. However, understanding its uses, proper administration, potential interactions, and storage guidelines is vital to maximize its benefits while minimizing risks. As with any medication, consulting your healthcare provider is the key to a safe and effective experience with magnesium trisilicate.

Drug Nomenclature

Synonyms: E553(a); Magnézium-triszilikát; Magnesii Trisilicas; Magnesio, trisilicato de; Magnesiumtrisilikaatti; Magnesiumtrisilikat; Magnio trisilikatas; Trikřemičitan hořečnatý

CAS: 14987-04-3 (anhydrous magnesium trisilicate); 39365-87-2 (magnesium trisilicate hydrate).

Description. Magnesium trisilicate is a hydrated magnesium silicate. The code E553(a) has been applied to both magnesium silicate and magnesium trisilicate.

Pharmacopoeias. In China, Europe, US.

European Pharmacopoeia, 6th ed. (Magnesium Trisilicate). It has a variable composition corresponding approximately to the formula Mg2Si3O8,xH20 containing not less than 29% magnesium oxide and not less than the equivalent of 65% silicon dioxide, both calculated concerning the ignited substance. A white or almost white powder. It is practically insoluble in water and alcohol.

The United States Pharmacopeia 31, 2008 (Magnesium Trisilicate). A compound of magnesium oxide and silicon dioxide with varying proportions of water. It contains not less than 20% of magnesium oxide and not less than 45% of silicon dioxide. A fine, white, odorless powder, free from grittiness. Insoluble in water and alcohol. It is readily decomposed by mineral acids.


British Pharmacopoeia 2008: Compound Magnesium Trisilicate Oral Powder; Compound Magnesium Trisilicate Tablets; Magnesium Trisilicate Mixture

The United States Pharmacopeia 31, 2008: Alumina and Magnesium Trisilicate Oral Suspension; Alumina and Magnesium Trisilicate Tablets; Magnesium Trisilicate Tablets.


Used as an adjunct in:

Sweden: Deltison.

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