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Magnesium Trisilicate

Drug Nomenclature

Synonyms: E553(a); Magnézium-triszilikát; Magnesii Trisilicas; Magnesio, trisilicato de; Magnesiumtrisilikaatti; Magnesiumtrisilikat; Magnio trisilikatas; Trikřemičitan hořečnatý
CAS: 14987-04-3 (anhydrous magnesium trisilicate); 39365-87-2 (magnesium trisilicate hydrate)
Read code: y03Lm

Description. Magnesium trisilicate is a hydrated magnesium silicate. The code E553(a) has been applied to both magnesium silicate and to magnesium trisilicate.

Pharmacopoeias. In China, Europe, US.

European Pharmacopoeia, 6th ed. (Magnesium Trisilicate). It has a variable composition corresponding approximately to the formula Mg2Si3O8,xH20 containing not less than 29% of magnesium oxide and not less than the equivalent of 65% of silicon dioxide, both calculated with reference to the ignited substance. A white or almost white powder. Practically insoluble in water and in alcohol.

The United States Pharmacopeia 31, 2008 (Magnesium Trisilicate). A compound of magnesium oxide and silicon dioxide with varying proportions of water. It contains not less than 20% of magnesium oxide and not less than 45% of silicon dioxide. A fine, white, odourless, powder, free from grittiness. Insoluble in water and in alcohol. It is readily decomposed by mineral acids.

Magnesium Trisilicate

Profile

Magnesium trisilicate is a hydrated magnesium silicate. It is an antacid with general properties similar to those of magnesium hydroxide. It may be given in typical oral doses of up to about 500 mg as required, although higher doses have been given. . When given orally it reacts more slowly with hydrochloric acid in the stomach than magnesium hydroxide. Magnesium trisilicate is often given with aluminium-containing antacids such as aluminium hydroxide, which counteract its laxative effect. Magnesium trisilicate is also used as a food additive and as a pharmaceutical excipient.

Effects on the kidneys. The formation of renal calculi containing silica is unusual, but has been reported in a small number of patients. In most of these cases, stone formation was attributed to the prolonged, and sometimes excessive, intake of antacids that contained magnesium trisilicate.

Preparations

British Pharmacopoeia 2008: Compound Magnesium Trisilicate Oral Powder; Compound Magnesium Trisilicate Tablets; Magnesium Trisilicate Mixture

The United States Pharmacopeia 31, 2008: Alumina and Magnesium Trisilicate Oral Suspension; Alumina and Magnesium Trisilicate Tablets; Magnesium Trisilicate Tablets.

Multi-ingredient

Used as an adjunct in:

Sweden: Deltison.

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