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Magnesium Oxide

Drug Nomenclature

Synonyms: E530; Magnesii Oxidum; Magnesio, óxido de; Magnesiumoksidi; Magnesiumoxid; Magnio oksidas; Nehéz magnézium; Oxid hořečnatý
Molecular formula: MgO =40.30
CAS: 1309-48-4
ATC code: A02AA02; A06AD02; A12CC10

Pharmacopoeias. In China, Europe, International., Japan, US. Some pharmacopoeias include a single monograph that permits both the light and heavy varieties while some have 2 separate monographs for the 2 varieties.

European Pharmacopoeia, 6th ed. (Magnesium Oxide, Heavy Magnesii Oxidum Ponderosum). A fine, white or almost white powder. 15 ghas an apparent volume before settling of not more than 60 mL. Practically insoluble in water dissolves in dilute acids with at most slight effervescence.

European Pharmacopoeia, 6th ed. (Magnesium Oxide, Light Magnesii Oxidum Leve). A fine, white or almost white, amorphous powder. 15 g has an apparent volume before settling of at least 100 mL. Practically insoluble in water dissolves in dilute acids with at most slight effervescence.

The United States Pharmacopeia 31, 2008 (Magnesium Oxide). A very bulky, white powder, or a relatively dense, white powder, or a granulated powder. Practically insoluble in water insoluble in alcohol soluble in dilute acids. Store in airtight containers.

Magnesium_Oxide_250mg

Profile

Magnesium oxide is an antacid with general properties similar to those of magnesium hydroxide (above). It is given in usual oral doses of about 400 mg. It is often given with aluminium-containing antacids such as aluminium hydroxide, which counteract its laxative effect.

Magnesium oxide has been used for its osmotic laxative properties in bowel preparation oral doses of 3.5 g are given for this purpose, combined with bisacodyl or sodium picosulfate.

Magnesium oxide is also used as a magnesium supplement in deficiency states in oral doses of up to 800 mg (20 mmol) daily. It is also used as a food additive.

Preparations

The United States Pharmacopeia 31, 2008: Alumina, Magnesium Carbonate, and Magnesium Oxide Tablets; Aromatic Cascara Fluidextract Aspirin, Alumina, and Magnesium Oxide Tablets; Citric Acid, Magnesium Oxide, and Sodium Carbonate Irrigation Magnesium Oxide Capsules; Magnesium Oxide Tablets.

Proprietary Preparations

Argentina: Magneforte †; Polvo Roge; SG 33

Austria: Magnonorm; Magnotab

Denmark: Salilax

France: Mag 2 Junior; Magocean; Sargemag; Thalamag

Germany: Biolectra Magnesium 240; Biolectra Magnesium 365; Magium; Magnesium Diasporal; Magnesium Tonil; Magnetrans extra; Magnetrans forte; Magno Sanol

Hungary: Magnosolv

New Zealand: Mylanta Effervescent

South Africa: Solumag

Sweden: Salilax

Thailand: Magoral

Turkey: Magnezi Kalsine

USA: Mag-200; Mag-Caps; Mag-Ox; Maox Uro-Mag.

Multi-ingredient

Used as an adjunct in:

Argentina: Aspirina; Bufferin

Brazil: Bufferin

Canada: Aspirin with Stomach Guard; Bufferin; Tri-Buffered ASA

Italy: Bufferin

Poland: Aspimag; Cardiofil

USA: Adprin-B; Bufferin; Cama Arthritis Pain Reliever; Extra Strength Bayer Plus.

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