Pharmacopoeias. In Europe and US.
European Pharmacopoeia, 6th ed. (Magnesium Citrate, Anhydrous). A white or almost white, fine, slightly hygroscopic powder. Soluble in water practically insoluble in alcohol. It dissolves in dilute hydrochloric acid. Store in non-metallic, airtight containers.
The United States Pharmacopeia 31, 2008 (Magnesium Citrate). A 5% suspension in water has a pH of 5.0 to 9.0. Store in airtight containers.
Magnesium citrate is an osmotic laxative used as a bowel evacuant before investigational procedures or surgery of the colon. Dosages have ranged from about 11 to 25 g of magnesium citrate. In the UK, an aqueous solution containing magnesium citrate is prepared from a sachet (Citramag) containing about 11.6 g of magnesium carbonate and about 17.8 g of anhydrous citric acid by mixing with 200 mL of hot water. After the solution has cooled, one dose (the contents of one sachet) is taken by mouth at 8 a.m. the day before the procedure, and a second dose between 2 and 4 p.m. For doses in children, see below. A high fluid intake and low residue diet are needed with such bowel preparations. Magnesium citrate is also used with sodium picosulfate.
Magnesium citrate is given as a magnesium supplement in doses of up to about 1.9 g daily by mouth.
For the general properties of magnesium salts.
Administration in children. The BNFC recommends the following oral doses of magnesium citrate (Citramag) for use as a bowel cleanser in children, to be taken on the day before the procedure:
• 5 to 10 years: / of a sachet at 8 a.m. and / of a sachet between 2 and 4 p.m.
• 10 to 18 years: / to 1 sachet at 8 a.m. and / to 1 sachet between 2 and 4 p.m.
For reconstitution directions, see above.
Migraine. For mention of the use of magnesium supplementation, including magnesium citrate, for the prophylaxis of migraine.
The United States Pharmacopeia 31, 2008: Magnesium Citrate for Oral Solution.
Argentina: Holomagnesio Limonada Roge
Australia: Mag Cit Prep
Austria: Magnesium Diasporal Magnofit
Canada: Citro-Mag Mag-Citrate
Czech Republic: Magnesium Diasporal Magnesol
Germany: Magnesium Diasporal Magnesium Verla N Presselin Heilozon P
Hong Kong: Citro-Mag
Hungary: Magnesium Diasporal
Switzerland: Magnegon Magnesium Biomed Magnesium Diasporal Magnesium-Sandoz
Argentina: Holomagnesio B6 Magnebe Total Magnesiano B6
Australia: Go Kit Go Kit Plus
Canada: Royvac Kit
France: Citrocholine Magne-B
Germany: Acidovertl Lithurex S Magnerot N
Greece: Magnesium Sandoz
Hungary: Beres Magnezium + B Magurlit † Pregmag
UK: CitraFleet Picolax.