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Magnesium Citrate

Drug Nomenclature

Molecular formula: C12H10Mg3O14 =451.1
CAS: 3344-18-1
ATC code: A06AD19; A12CC04; B05CB03
Read code: y01SE

Pharmacopoeias. In Europe and US.

 

European Pharmacopoeia, 6th ed. (Magnesium Citrate, Anhydrous). A white or almost white, fine, slightly hygroscopic powder. Soluble in water practically insoluble in alcohol. It dissolves in dilute hydrochloric acid. Store in non-metallic, airtight containers.

The United States Pharmacopeia 31, 2008 (Magnesium Citrate). A 5% suspension in water has a pH of 5.0 to 9.0. Store in airtight containers.

Profile

Magnesium citrate is an osmotic laxative used as a bowel evacuant before investigational procedures or surgery of the colon. Dosages have ranged from about 11 to 25 g of magnesium citrate. In the UK, an aqueous solution containing magnesium citrate is prepared from a sachet (Citramag) containing about 11.6 g of magnesium carbonate and about 17.8 g of anhydrous citric acid by mixing with 200 mL of hot water. After the solution has cooled, one dose (the contents of one sachet) is taken by mouth at 8 a.m. the day before the procedure, and a second dose between 2 and 4 p.m. For doses in children, see below. A high fluid intake and low residue diet are needed with such bowel preparations. Magnesium citrate is also used with sodium picosulfate.

Magnesium citrate is given as a magnesium supplement in doses of up to about 1.9 g daily by mouth.

For the general properties of magnesium salts.

magnesium-citrate-200-mg

Administration in children. The BNFC recommends the following oral doses of magnesium citrate (Citramag) for use as a bowel cleanser in children, to be taken on the day before the procedure:

• 5 to 10 years: / of a sachet at 8 a.m. and / of a sachet between 2 and 4 p.m.

• 10 to 18 years: / to 1 sachet at 8 a.m. and / to 1 sachet between 2 and 4 p.m.

For reconstitution directions, see above.

Migraine. For mention of the use of magnesium supplementation, including magnesium citrate, for the prophylaxis of migraine.

magnesium-citrate-250-mg

Preparations

The United States Pharmacopeia 31, 2008: Magnesium Citrate for Oral Solution.

Proprietary Preparations

Argentina: Holomagnesio Limonada Roge

Australia: Mag Cit Prep

Austria: Magnesium Diasporal Magnofit

Belgium: Magnetop

Canada: Citro-Mag Mag-Citrate

Czech Republic: Magnesium Diasporal Magnesol

Germany: Magnesium Diasporal Magnesium Verla N Presselin Heilozon P

Hong Kong: Citro-Mag

Hungary: Magnesium Diasporal

Poland: Magnesol

Switzerland: Magnegon Magnesium Biomed Magnesium Diasporal Magnesium-Sandoz

UK: Citramag

USA: Evac-Q-Mag

Multi-ingredient

Argentina: Holomagnesio B6 Magnebe Total Magnesiano B6

Australia: Go Kit Go Kit Plus

Austria: Magnosolv

Belgium: Carbobel

Canada: Royvac Kit

Chile: Laxogeno

France: Citrocholine Magne-B

Germany: Acidovertl Lithurex S Magnerot N

Greece: Magnesium Sandoz

Hungary: Beres Magnezium + B Magurlit † Pregmag

Ireland: Picolax

Italy: Pomag

Spain: Salmagne

UK: CitraFleet Picolax.

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