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Magnesium Carbonate

Drug Nomenclature

Synonyms: Bázisos magnézium-karbonát; E504; Magnesii Subcarbonas; Magnesio, carbonato de; Magnesiumsubkarbonaatti; Magnesiumsubkarbonat; Magnio subkarbonatas; Uhličitan hořečnatý zásaditý
CAS: 546-93-0 (anhydrous magnesium carbonate); 23389-33-5 (hydrated normal magnesium carbonate); 39409-82-0 (hydrated basic magnesium carbonate)
ATC code: A02AA01; A06AD01
Read code: y03Lk; y06v0

Pharmacopoeias. In China, Europe, Japan, US. Some pharmacopoeias include a single monograph that permits both the light and heavy varieties while some have 2 separate monographs for the 2 varieties.

European Pharmacopoeia, 6th ed. (Magnesium Carbonate, Heavy Magnesii Subcarbonas Ponderosus). A hydrated basic magnesium carbonate containing the equivalent of 40 to 45% of MgO. A white or almost white powder. 15 ghas an apparent volume before settling of not more than 60 mL. Practically insoluble in water dissolves in dilute acids with strong effervescence.

European Pharmacopoeia, 6th ed. (Magnesium Carbonate, Light Magnesii Subcarbonas Levis). A hydrated basic magnesium carbonate containing the equivalent of 40 to 45% of MgO. A white or almost white powder. 15 g has an apparent volume before settling of at least 100 mL. Practically insoluble in water dissolves in dilute acids with strong effervescence.

The United States Pharmacopeia 31, 2008 (Magnesium Carbonate). A basic hydrated magnesium carbonate or a normal hydrated magnesium carbonate containing the equivalent of 40.0 to 43.5% of MgO. It is an odourless, bulky white powder or light, white, friable masses. Practically insoluble in water insoluble in alcohol dissolves in dilute acids with effervescence.

Magnesium_Carbonate

Profile

Magnesium carbonate is an antacid with general properties similar to those of magnesium hydroxide (below) that is given in oral doses of up to about 500 mg. When given orally, it reacts with gastric acid to form soluble magnesium chloride and carbon dioxide in the stomach the carbon dioxide may cause flatulence and eructation. Magnesium carbonate is often given with aluminium-containing antacids such as aluminium hydroxide, which counteract its laxative effect.

Magnesium carbonate may be used as a magnesium supplement. It is also used as a food additive.

Preparations

BP 2008: Aromatic Magnesium Carbonate Mixture; Compound Magnesium Trisilicate Oral Powder Kaolin Mixture; Magnesium Sulphate Mixture; Magnesium Trisilicate Mixture

The United States Pharmacopeia 31, 2008: Alumina and Magnesium Carbonate Oral Suspension; Alumina and Magnesium Carbonate Tablets; Alumina, Magnesium Carbonate, and Magnesium Oxide Tablets; Calcium and Magnesium Carbonates Oral Suspension; Calcium and Magnesium Carbonates Tablets; Magnesium Carbonate and Citric Acid for Oral Solution; Magnesium Carbonate and Sodium Bicarbonate for Oral Suspension; Magnesium Carbonate, Citric Acid, and Potassium Citrate for Oral Solution; Magnesium Citrate Oral Solution.

Proprietary Preparations

Argentina: Polvo Roge

Austria: Magnofit

France: Mag 2; Mag 2 Junior; Sargemag

Germany: Biolectra Magnesium 365; Palmicol

Greece: Limonata Citromagnes

Hungary: Magnosolv

Italy: Magnofit

Poland: Additiva Magnesium; Magnezin

South Africa: Be-Lax

Switzerland: Magnesium Nutrimed

USA: Mag-Carb.

Multi-ingredient

Used as an adjunct in:

Argentina: Bufferin; Dristan Analgesico; Dristan Compuesto

Brazil: Bufferin; Somalgin

Canada: Aspirin with Stomach Guard; Bufferin; Tri-Buffered ASA

Italy: Bufferin

USA: Adprin-B; Bufferin; Buffex; Extra Strength Bayer Plus.

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