Combining Antipsychotics

How do you feel about the use of risperidone in combination with other antipsychotic medications such as Haldol and Prolixin? I have recently started work at a community mental health clinic and treat a large number of patients with chronic schizophrenia who have been only partially responsive to traditional antipsychotic medication. The use of risperidone in combination with other antipsychotic medications such as Haldol and Prolixin appears to have stabilized several of my patients and has been fairly well-tolerated.

Case: Antipsychotic drugs. Questions – Answers

Haloperidol-induced Parkinson syndrome is a result of inhibition of dopamine D2 receptors in the nigrostriatal tract of the CNS. Antipsychotic drugs like haloperidol exert their therapeutic effect, at least in part, by inhibition of dopamine’s action at dopamine D2 receptors in the mesocortical and mesolimbic dopaminergic pathways of the CNS. A number of adverse effects of these drugs are caused by inhibition of dopamine action in the nigrostriatal and tuberoinfundibular dopaminergic pathways of the CNS; blockade of histamine, muscarinic, cholinergic, and ?-adrenergic receptors in the CNS and the peripheral nervous system are also contributory.

Mixing Psychotropics and Street Drugs

In addition to my practice, I sit on the advisory committee of a group interested in providing mental health services to the homeless, who often abuse alcohol and drugs. The intent of this program is to provide psychotropic medication as part of its treatment to these people. Is this a wise course of action? What are the consequences of concomitant use of these medications and street drugs?Answer.

Constipation Management

Constipation is a common problem experienced by many patients and can be caused by chemotherapy, radiation, surgery, stress, or medications. Please do not be afraid or embarrassed to call your doctor or nurse at any time; if left untreated the constipation may get worse and not improve on its own. Many chemotherapy and anti-nausea medications cause constipation, so when starting chemotherapy take a stool softener like Ducosate every day unless otherwise directed.