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Last updated on November 22nd, 2021

Generic name: Bisoprolol-Hydrochlorothiazide

Brand name: Ziac

General Information:

Ziac is a combination of a beta-blocker and a diuretic. It is taken to cure high blood pressure.

Your physician may prescribe this remedy for other purposes. Contact him or her if you want to learn more about this drug.

Don’t stop treatment with Ziac earlier than it was prescribed by your physician even if you feel improvements of your condition. Stopping the medication too early may worsen your condition. Be careful about doing dangerous tasks, driving, operating machinery or climbing until you are aware how this drug affects you. Don’t drink alcohol. Always contact a medic before giving Ziac to a child.

What symptoms or conditions should I report to a doctor before I take this medicine?

It is important to report to a doctor if you have or had the following conditions:

  • diabetes
  • liver or kidney disease
  • pregnant or trying to get pregnant
  • blood vessel disorder or circulation problems
  • heart disorder
  • decreased urine
  • thyroid disease
  • history of heart attack or heart failure
  • breast-feeding
  • slow heart rate
  • an unusual or allergic reaction to bisoprolol, hydrochlorothiazide, sulfa drugs, other pharmaceutical, dyes, foods, or preservatives
  • breathing or lung disorder, like asthma

How do I take this medicine?

Note: This remedy was prescribed to you only. Don’t share this medicament with others. Follow strictly your doctor’s recommendations. Don’t take more or longer than your doctor recommended.

Take this remedy orally with a glass of water with or without food.


Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.

What should be done if I missed the dose?

In case you forgot to take the dose, take it at your earliest opportunity. Never double your dose if it is almost time for your next dose. Take only one dose at once.


  • lithium pill for chest pain
  • angina remedy
  • prescription pain drugs
  • barbiturates (phenobarbital)
  • diabetes pharmaceutical
  • rifampin skeletal muscle relaxants (tubocurarine)
  • cholestyramine colestipol corticosteroids (prednisone)
  • pill for pain and inflammation (naproxen, ibuprofen)
  • high blood pressure or heart failure remedy to control heart rhythm NSAIDs

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.


Side Effects:

Contact your physician immediately if you notice any of the following

Serious side effects:

  • allergy like skin rash, swelling of the face, lips, tongue, hives, itching, difficulty breathing
  • unusual bruising
  • breathing problems
  • muscle cramps
  • vomiting
  • chest pain
  • worsened gout pain
  • yellowing of the skin or eyes
  • irregular, fast or slow heartbeat
  • unusual tired or weak
  • increased sweating
  • cold, tingling, or numb feet or hands
  • increased thirst
  • swollen legs or ankles tremors
  • redness, peeling, blistering or loosening of the skin, including inside the mouth

Less serious side effects:

  • diarrhea
  • cough
  • nausea
  • change in sex drive or performance
  • depression

This list of side effects may be not complete, others may occur. Inform your medical practitioners about all side effects you experience.

Important Information:

Visit your physician regularly to check your condition. Check also your blood pressure as recommended by your doctor.

Contact your doctor in case you experience an attack of severe diarrhea, vomiting or nausea, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to use this pill.

Be informed that Ziac may affect your blood sugar level. In case you have diabetes, consult your physician before changing the dose of your diabetic drugs.

This drug can make you more sensitive to the sun.

Don’t cure yourself for colds, coughs or pain while you are taking this remedy without consulting your doctor first.



Ziac should be stored at room temperature, in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Ziac out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor. The information contained in this article is not intended to cover all possible precautions, drug interactions, adverse effects, directions, uses, allergic reactions or warnings.

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