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Last updated on November 22nd, 2021

Generic name: Lisinopril-hctz

Brand name: Zestoretic

General Information:

Zestoretic is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Lisinopril belongs to a group of drugs called ACE (angiotensin converting enzyme) inhibitors. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention. Zestoretic is prescribed to heal high blood pressure.

Your doctor may prescribe this remedy for other purposes. Contact your physician if you need to learn more information about this drug.

Don’t stop treatment with Zestoretic earlier than it was prescribed by your doctor even if you notice improvements of your condition. Stopping the medication too early may worsen your condition. Be careful about doing dangerous tasks, driving, operating machinery or climbing until you are aware how this drug affects you. Don’t drink alcohol. Always contact a medic before giving Zestoretic to a child.

What symptoms or conditions should I report to a doctor before I take this medicine?

It is important to report to a doctor if you have or had the following conditions:

  • lupus
  • liver disease
  • allergy to sulfa drugs
  • congestive heart failure
  • an unusual or allergic reaction to Zestoretic, other dyes, preservatives, foods or medicines
  • gout
  • kidney disease (or are on dialysis)
  • diabetes

How do I take this medicine?

Note: This remedy was prescribed to you only. Don’t share this medicament with others. Follow strictly your doctor’s recommendations. Don’t take more or longer than your doctor recommended.

This drug is taken orally with some water with or without food. Take the doses on the rigid schedule. Avoid taking the drug more often than prescripted.


Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.

In large doses, this remedy may cause the following conditions:

  • dry mouth
  • muscle pain
  • weakness
  • thirst
  • dizziness
  • nausea
  • feeling like you might pass out

What should be done if I missed the dose?

In case you forgot to take the dose, take it at your earliest opportunity. Never double your dose if it is almost time for your next dose. Take only one dose at once.


  • lithium (Eskalith, Lithobid)
  • diabetes or insulin medicine taken by mouth
  • colestipol (Colestid) or cholestyramine (Questran, Prevalite)
  • gold injections to treat arthritis
  • other diuretics (water pills) or blood pressure medications
  • NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), aspirin, indomethacin, diclofenac (Voltaren), piroxicam (Feldene), etodolac (Lodine), naproxen (Naprosyn, Aleve), nabumetone (Relafen), and others
  • steroids (prednisone and others)

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.


Side Effects:

Contact your physician immediately if you notice any of the following

Serious side effects:

  • allergy like skin rash, swelling of the face, lips, tongue, hives, itching, difficulty breathing
  • jaundice (yellowing of the eyes or skin)
  • feeling drowsy, weak, light-headed, restless
  • a red, peeling, blistering skin rash
  • high potassium (slow heart rate, muscle weakness, weak pulse,  tingly feeling)
  • swelling, feeling short of breath, weight gain,
  • low potassium (uneven heart rate, confusion, increased urination, extreme thirst, muscle weakness,  leg discomfort, or limp feeling)
  • thirst, , dry mouth, vomiting, nausea
  • urinating less than usual or not at all
  • flu symptoms, chills, fever, body aches

Less serious side effects:

  • blurred vision
  • cough
  • depressed mood
  • constipation
  • diarrhea
  • tired feeling
  • increased sweating
  • upset stomach
  • headache
  • dizziness
  • mild skin rash

This list of side effects may be not complete, others may occur. Inform your medical practitioners about all side effects you experience.

Important Information:

Check your blood pressure regularly. Check with your doctor before you use a salt substitute or a product that has potassium in it. Don’t take salt substitutes and potassium supplements while taking Zestoretic, unless your physician recommends doing otherwise. If you are going to have any type of surgery, you may need to temporarily stop using Zestoretic. Make sure your surgeon is informed that you are taking Zestoretic.

Don’t take Zestoretic if you are unable to urinate. Avoid standing or sitting up quickly, especially if you are an older patient.

Be prepared that lab tests, including blood electrolytes, blood pressure, blood cell counts, and kidney function may be performed while you take Zestoretic.

Inform your docotr if you are pregnant, breast-feeding or trying to get pregnant.


Zestoretic should be stored at room temperature, in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Zestoretic out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor. The information contained in this article is not intended to cover all possible precautions, drug interactions, adverse effects, directions, uses, allergic reactions or warnings. 

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