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Last updated on November 21st, 2021

Generic name: Amiloride-hydrochlorothiazide

Brand name: Moduretic

Moduretic Information:

Moduretic belongs to a diuretic combination used in the treatment of congestive heart failure and high blood pressure, conditions which require the elimination of excess fluid (water) from the body. When used for high blood pressure, Moduretic can be used alone or with other high blood pressure medications. Diuretics help your body produce and eliminate more urine, which helps lower blood pressure. Amiloride, one of the ingredients, helps minimize the potassium loss that can be caused by the other component, hydrochlorothiazide. This medication may be used to gain other purposes; appeal to your doctor or pharmacist on the occasion that you have the desire to interrogate something.

What symptoms or conditions should I report to a doctor before I take this medicine?

It is important to report to a doctor if you have or had the following conditions:

  • allergy to any foods, medicines or other substances
  • cirrhosis or liver problems
  • pregnant, breast-feeding or you are planning to become pregnant
  • diabetes
  • kidney problems or kidney stones,
  • you are taking any nonprescription or prescription drugs, dietary supplement, herbal preparation
  • asthma
  • you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated
  • heart problems
  • gout
  • systemic lupus erythematosus (SLE or lupus)

How do I take this medicine?

Note: This remedy was prescribed to you only. Don’t share this medicament with others. Follow strictly your doctor’s recommendations. Don’t take more or longer than your doctor recommended.

This medicine should be taken orally with a glass of water and with food. If you take this drug at bedtime, you may need to wake up to urinate. Therefore, it is better to take this drug at least 4 hours before your bedtime. Use this remedy regularly to get the most benefit from it. Take the doses at fixed intervals. Avoid taking your medicament more often than prescribed.


Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.

In large doses, this remedy may cause the following conditions:

  • weakness
  • dizziness

If you forget about a dose:

In case you forgot to take the dose, take it at your earliest opportunity. Never double your dose if it is almost time for your next dose. Take only one dose at once.


  •     ACE inhibitors such as enalapril
  •     Barbiturates such as phenobarbital
  •     Cholestyramine
  •     Colestipol
  •     Corticosteroids such as prednisone
  •     Cyclosporine
  •     Insulin
  •     Lithium
  •     Muscle relaxants such as tubocurarine
  •     Narcotics such as oxycodone
  •     Nonsteroidal anti-inflammatory drugs such as naproxen
  •     Norepinephrine
  •     Oral drugs for treating diabetes such as glyburide
  •     Other high blood pressure medications
  •     Tacrolimus

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.

Which side effects can I perceive from this remedy?

Contact your physician immediately if you notice any of the following

Serious side effects:

  • allergy like skin rash, swelling of the face, lips, tongue, hives, itching, difficulty breathing
  • severe dizziness
  • muscle cramps
  • unusual change in the amount of urine
  • very dry mouth
  • fainting
  • dark urine
  • extreme thirst
  • fast heartbeat
  • weakness
  • trouble breathing
  • confusion
  • joint pain
  • persistent nausea/vomiting
  • seizures
  • yellowing eyes/skin

Side effects which as a rule don’t need medical awareness

(tell your doctor if they last or are inconvenient):

  • loss of appetite
  • dizziness
  • diarrhea
  • headache
  • vomiting
  • stomach/abdominal pain
  • nausea
  • gas

This list of side effects may be not complete, others may occur. Inform your medical practitioners about all side effects you experience.

Important Information:

Visit your physician regularly to check your progress. Also check your blood pressure as recommended.

Contact your physician in case you experience an irregular or fast heart beat Avoid drinking alcohol. Don’t take potassium supplements or salt substitutes while you are treating with Moduretic, unless otherwise is recommended by your doctor.

FDA pregnancy category C. It is better to avoid taking Moduretic during pregnancy and breast-feeding. Discuss the risks and benefits with your doctor.

Contact your doctor if you have coughs, colds, or pain while you are taking this medicine. Don’t take any other medicines without consulting your doctor first.

In addition to the use of this medicine, treatment of the high blood pressure may include diet and weight control. Your doctor will provide you with detailed instructions.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking other diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. Before having surgery, tell your doctor or dentist that you are taking this medication.


Moduretic should be stored at room temperature, in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Moduretic out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor. The information contained in this article is not intended to cover all possible precautions, drug interactions, adverse effects, directions, uses, allergic reactions or warnings.

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