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Last updated on: November 22nd, 2021

Generic name: Domperidone

Brand names: Motilium, Cilroton, Euciton, Nauseline, Nauzelin, Peridal, Peridon

Pharmacological action:

Blocks peripheral and central (in the trigger zone of the brain) dopamine receptors, eliminates inhibitory effect of dopamine on the motor function of the digestive tract and increases the evacuation and the motor activity of the stomach. Has antiemetic effect, eliminates hiccup and nausea. Augments prolactin levels in serum.


Vomiting and nausea of various origins (including on the background of functional and organic diseases, toxemia, diet disorders, radiation therapy, infections, drug genesis – receiving morphine, apomorphine, levodopa and bromocriptine with an endoscopy and X-ray studies GIT), hiccups, gastrointestinal atony (including postoperative); the need to accelerate the peristalsis during the X-ray studies the digestive tract. Dyspeptic violations against the slow oprozhneniya stomach, and gastroesophageal reflux esophagitis: feeling of bloating, stomachalgia, flatulence, heartburn with GERD and without GERD gastric contents into the mouth, a sense of overflow in the epigastrium, belching.



Hypersensitivity, mechanical intestinal obstruction, children’s age (up to 5 years and children weighing up to 20 kg) – for tablets, prolaktinoma, bleeding from the gastrointestinal tract, perforation of the stomach or intestine. Renal / hepatic insufficiency, during lactation, pregnancy.

Side effects:

Digestive system:

transient spasm of the intestine

The nervous system:

extrapyramidal disorder (in children and patients with increased permeability of the BBB)

Allergic reaction:

skin rash, urticaria


hyperprolactinemia (galactorrhea, gynecomastia)


Inside, 30 minutes before the meal.

Adults and children over 5 years with chronic dyspeptic symptoms – 10 mg 3-4 times per day and if needed additionally before bedtime. When expressed nausea and vomiting – 20 mg 3-4 times per day and at bedtime. Children younger than 5 years with chronic dyspeptic symptoms – to 2.5 mg/10 kg 3 times per day and if necessary additionally before bedtime.

When expressed nausea and vomiting – 5 mg/10 kg 3-4 times per day and before going to bed. If necessary, the dose may be doubled. For patients with renal insufficiency the dosage adjustment is required, the multiplicity of admission must not exceed 1-2 times during the day.


Cimetidine, sodium bicarbonate decreases the bioavailability of domperidone. Anticholinergic medicines neutralize the action of domperidone. Augments the concentration of domperidone in plasma.


To keep in dark place at a temperature not exceeding 25 ° C.

Warning: Before using the medicine you should consult your doctor.

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