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Last updated on November 21st, 2021

Generic name: Repaglinide

Brand name: Prandin

General Information:

Prandin is prescribed to cure type 2 (non-insulin-dependent) diabetes in people which are not able to control the level of blood sugar by exercise and diet. Prandin can be prescribed to take alone or together with other antidiabetic medications. Prandin is prescribed to lower the blood glucose (sugar) level in the body. It works by stimulating the release of insulin from the pancreas gland. Don’t take Prandin in type 1 (insulin-dependent) diabetes. Like Sulfonylureas, for example, glyburide (Glynase, Diabeta, Micronase), tolbutamide (Orinase), glimepiride (Amaryl), tolazamide (Tolinase), glipizide (Glucotrol).

Controlling high blood sugar helps prevent strokes, circulation problems, heart disease, kidney disease and blindness, as well as sexual function problems (impotence).

When shouldn’t Prandin be used?

Don’t take Prandin and contact your physician if you have the following conditions:

  •     allergy to any ingredient contained in Prandin
  •     you are taking gemfibrozil
  •     you have type 1 diabetes
  •     certain severe problems associated with diabetes (eg, diabetic ketoacidosis, diabetic coma)

Special Warnings:

Consult your physician in case any of the following conditions apply to you:

  •     pregnancy, breast-feeding or if you are planning to have a baby
  •     you are taking any nonprescription or prescription remedies, dietary supplements or herbal preparation
  •     you have pituitary, adrenal, kidney or liver disorders
  •     you have a history of high blood acid levels (acidosis)
  •     you have allergies to foods, medicines or other substances
  •     you are going to have surgery
  •     you drink alcohol
  •     you have very poor health, high fever,
  •     you have severe infection or injury, or have had poor nutrition

How should Prandin (Repaglinide) be taken?

Note: This remedy was prescribed to you only. Don’t share this medicament with others. Follow strictly your doctor’s recommendations. Don’t take more or longer than your doctor recommended.

Take Prandin orally 15-30 min before meal. Ask your medical assistant if you need to learn more information.

What should I do if I miss the dose?

If you miss the dose, try to take it as soon as you have the opportunity. If it is time for your next dose, take only one dose. You don’t have to double the dose.


Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.

In large doses, this remedy may cause the following conditions:

  • personality changes
  • shakiness
  • seizure
  • fatigue
  • dizziness
  • confusion
  • fainting
  • nausea

Important Information:

You may feel dizzy. Alcohol or certain drugs may worsen this condition. Limit alcohol intake, as it may aggravate drug side effects.

Follow the exercise program and diet prescribed by your medical assistant.

Try to carry an ID card with you which contain the information that you have diabetes. Don’t forget to check your blood sugar levels.

Prandin may lower your blood sugar level. That is why you may feel drowsy, faint, dizzy, weak, anxious or sweaty. It may also make your vision change, make your heart beat faster, chills, tremors, headache or increase hunger. To treat low blood sugar level quickly, carry glucose with you (eg, tablets or gel) . You may also eat or drink a quick some products like honey, table sugar, orange juice, candy or non-diet soda. Inform your medical assistant if it happens.

During times of stress, such as fever, infection, injury or surgery it may be more difficult to control your blood sugar level. Contact your medical assistant since the dose adjustment may be required.

Tell your medical assistant or dentist that you use this remedy before you receive any dental or medical care.

Elderly people should take Prandin with caution. Low blood sugar levels may also be more difficult to recognize in the elderly.

Effectiveness and safety in children have not been confirmed; don’t give Prandin to a child before consulting your doctor.

Take this pill only when clearly needed during pregnancy and breast-feeding.

Which side effects can I perceive from this remedy?

Most common side effects:

  • headache
  • nasal or chest congestion
  • diarrhea
  • sinus inflammation
  • back or joint pain

Contact your physician immediately if you notice any of the following

Serious side effects:

  • allergy like skin rash, swelling of the face, lips, tongue, hives, itching, difficulty breathing    chest pain
  • blurred vision or other vision problems
  • persistent sore throat, chills, fever
  • low blood sugar symptoms such as weakness, fast heartbeat, unusual sweating, severe or persistent dizziness, tremors, anxiety, headache, drowsiness or lightheadedness

This list of side effects may be not complete, others may occur. Inform your medical practitioners about all side effects you experience.


  •     chloramphenicol, probenecid, trimethoprim, macrolides and ketolides (for example, clarithromycin, erythromycin), anticoagulants (for example, warfarin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), montelukast, cyclosporine gemfibrozil, sulfonamides (for example, sulfamethoxazole), beta-blockers (for example, propranolol), salicylates (for example, aspirin), monoamine oxidase inhibitors (MAOIs) (for example, phenelzine) or imidazoles (eg, ketoconazole, itraconazole) since the risk of low blood sugar may be increased
  •     diuretics (eg, hydrochlorothiazide, furosemide), sympathomimetics (eg, pseudoephedrine), phenytoin, calcium channel blockers (for example, nifedipine), estrogen, phenothiazines (for example, chlorpromazine), hormonal contraceptives (eg, birth control pills), corticosteroids (for example, prednisone), thyroid hormones (eg, levothyroxine), isoniazid or nicotinic acid since the risk of high blood sugar may be increased
  •     insulin since it may increase the risk of Prandin ‘s side effects
  •     carbamazepine, barbiturates (eg, phenobarbital), or rifampin since they may decrease Prandin ‘s effectiveness

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.


Prandin should be stored at room temperature, in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Prandin out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor. The information contained in this article is not intended to cover all possible precautions, drug interactions, adverse effects, directions, uses, allergic reactions or warnings.

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