Asthmatics and Inhaled Corticosteroids

Inhaled corticosteroid therapy is fast becoming a mainstay of asthma therapy. Inhaled steroids appear to effectively break the cycle of inflammation that precipitates additional declines in pulmonary function in these patients. Nevertheless, a survey suggests that asthmatic patients do not comply with the prescribed long-term use of their inhaled steroid medications.

GCSs in treatment of asthma. Choice of inhaled glucocorticosteroid

Ninety percent of the inhaled dose from pressurized metered dose inhalers (MDIs) is delivered to the walls of the pharynx and only 10% reaches the sublaryngeal airways. A greater fraction of inhaled glucocorticosteroid reaches the sublaryngeal airway with some breath-activated dry powder devices, such as the Turbuhaler(R).