Corticosteroids

Practically insoluble in water and in dichloromethane slightly soluble in methyl alcohol. A white or practically white, odourless, crystalline powder.

Inhaled corticosteroid therapy is fast becoming a mainstay of asthma therapy. Inhaled steroids appear to effectively break the cycle of inflammation that precipitates additional declines in pulmonary function in these patients. Nevertheless, a survey suggests that asthmatic patients do not comply with the prescribed long-term use of their inhaled steroid medications.

This post compares the effectiveness, safety, and cost of medicines called inhaled corticosteroids, or just inhaled steroids. These medicines are primarily used to treat people with asthma. But they also are prescribed for people with a condition called chronic obstructive pulmonary (lung) disease, or COPD.

Ninety percent of the inhaled dose from pressurized metered dose inhalers (MDIs) is delivered to the walls of the pharynx and only 10% reaches the sublaryngeal airways. A greater fraction of inhaled glucocorticosteroid reaches the sublaryngeal airway with some breath-activated dry powder devices, such as the Turbuhaler(R).

Practically insoluble in water slightly soluble in alcohol sparingly soluble in dichloromethane. Micronised fluticasone propionate is a fine white powder.

In US which specifies the hernihydrate. A white to creamy-white crystalline powder.

Practically insoluble in water sparingly soluble in alcohol slightly soluble in acetone and in dichloromethane. A white to practically white, odourless, crystalline powder.