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Robinul-Neostigmine Injection (Glycopyrrolate and Neostigmine metilsulfate)

Last updated on: November 17th, 2021

Robinul-Neostigmine Injection. Glycopyrrolate 0.5mg and Neostigmine metilsulfate 2.5mg


Robinul-Neostigmine injection contains two active ingredients:

1. Neostigmine which belongs to a group of medicines called cholinesterase inhibitors. It has the effect of reversing the action of certain muscle-relaxing drugs.

2. Glycopyrrolate which belongs to a group of medicines called anticholinergic drugs. Its purpose is to block some of the unwanted effects that may occur with Neostigmine such as slowing the heart rate or excess production of saliva.

Robinul-Neostigmine Injection is used at the end of an operation to reverse the effects of some of the drugs used during surgery such as anaesthetics and muscle relaxants.


You should not be given Robinul-Neostigmine Injection if:

  • you know you are allergic to Glycopyrrolate or Neostigmine or any other ingredient present in this injection.
  • you have a blockage in your stomach, intestine or urinary passages such as bladder or kidneys.
  • you are also receiving suxamethonium, a muscle relaxant usually given during operations.

Make sure your doctor knows if you suffer from any of the above.

Before you are given Robinul-Neostigmine Injection, you should tell your doctor if:

  • you suffer from asthma or attacks of wheezing.
  • you suffer from glaucoma (increased pressure in the eye).
  • you have had a recent operation on the intestines (gut).
  • you have a very slow heart beat (less than 60 beats per minute) or you are suffering from coronary artery disease, heart failure, irregular heart beats or high blood pressure.
  • you have an overactive thyroid gland.
  • you are suffering from epilepsy or Parkinsonism (a disorder in the brain causing muscle stiffness and shaking).

Tell your doctor if any of these apply to you.

Taking other medicines

Please talk to your doctor if you are taking or have recently taken any other medicines, including medicines obtained without prescription.

Pregnancy and breast feeding

Ask your doctor for advice before taking this, or any other medicine, if you are pregnant, planning to become pregnant, think you may be pregnant or are breastfeeding.

Important information about some of the ingredients in Robinul-Neostigmine Injection

This injection contains less than 1mmol (23mg) of sodium per 2ml (essentially ‘sodium-free’).

Robinul-Neostigmine_Injection (Glycopyrrolate and_Neostigmine-metilsulfate)


Robinul-Neostigmine Injection is administered by injection into a vein.

Your doctor will decide the correct dose for you depending on your circumstances.

Your dose may be calculated according to your weight.

The injection is usually given over a period of 10-30 seconds, and may need to be repeated depending on your response.

What to do if you have been given more Robinul-Neostigmine Injection than you should

This is unlikely because the dose will be administered by a health professional. An overdose may cause changes in the speed of heart rate, increased production of saliva and difficulty in breathing. If you suspect you have been given too much, you should tell the doctor immediately.

If you have any further questions on the use of this product ask your doctor.


Like all medicines Robinul-Neostigmine Injection can sometimes cause side-effects, although not everybody gets them.

All medicines can cause allergic reactions although serious allergic reactions are very rare. Any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body) should be reported to a doctor immediately.

The following side effects have also been reported but their frequency is not known:

  • a dry mouth, difficulty in passing water (urinating), blurred vision or reduced ability to sweat (these could be related to Glycopyrrolate).
  • a very slow heart beat, too much saliva, tummy cramps, vomiting or diarrhoea (these could be related to Neostigmine).
  • palpitations (an awareness of strong, thumping heart beats) or irregular heart beats (could be related to either Glycopyrrolate or Neostigmine).

If any of the side effects become serious, or you notice any side effects not listed in this leaflet, please tell your doctor.


Keep out of the reach and sight of children.

Do not use this medicine after the expiry date which is stated on the carton and ampoule label after ‘Exp date’. The expiry date refers to the last day of that month.

Do not store above 25°C.

Keep the container in the outer carton in order to protect from light.

Once opened, use immediately

If only part used, discard the remaining solution.

Do not dilute.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.


The active substances are Glycopyrrolate (Glycopyrronium bromide) and Neostigmine metilsulfate.

The other ingredients are Disodium Phosphate Dodecahydrate, Citric Acid monohydrate, citric acid solution or sodium hydroxide (for pH adjustment) in water for injections.

What Robinul-Neostigmine Injection looks like and contents of pack

Robinul-Neostigmine Injection is a clear, colourless, sterile solution for injection.

Each glass ampoule contains 1 ml of solution, which contains the two active ingredients Glycopyrronium Bromide 0.5mg and Neostigmine Metilsulfate 2.5mg.

Each carton contains ten 1 ml ampoules of Robinul-Neostigmine Injection.

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