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Prochlorperazine Injection BP (Prochlorperazine Mesilate)

Last updated on: November 17th, 2021

Prochlorperazine Injection BP 12.5mg in 1ml and 25mg in 2ml. Prochlorperazine Mesilate


Prochlorperazine Injection belongs to a class of drugs called phenothiazine neuroleptics. It influences the activity of certain brain cells by decreasing the effect of dopamine, a natural chemical in the brain.

Prochlorperazine Injection may be used to improve the symptoms of major mental disorders such as in schizophrenia, acute mania, and short term treatment of anxiety. It may also be used to treat the symptoms of nausea (feeling sick) and vomiting (being sick), as well as symptoms of vertigo due to Menieres syndrome or labyrinthitis (inner ear disorders).


You should not be given Prochlorperazine Injection if:

  • you know that you are allergic to Prochlorperazine Mesilate or any of the other ingredients of Prochlorperazine Injection (see section 6 of this post).
  • the person is a child. This is because children may develop unusual face and body movements (dystonic reactions).

Before you are given Prochlorperazine Injection, your doctor will take special care if any of the following situations apply to you. Make sure your doctor is aware if you suffer from any of the following :

  • you suffer from any disease involving the heart and blood vessels (cardiovascular disease) including chest pain (angina) and irregular heart beats
  • you have a problem with your liver or kidneys
  • you have high blood pressure due to a tumour of a gland situated on top of the kidney (a condition known as phaeochromocytoma)
  • you  suffer from  a brain  disorder causing tremors,   rigidity and  slowing  of movement (Parkinson’s disease)
  • you suffer from fits (epilepsy)
  • you suffer from an eye disease called narrow angle glaucoma which causes increased pressure inside the eye
  • you have or have ever had a low number of white blood cells (agranulocytosis). This would lead you to get infections more easily than usual
  • you have ever had a stroke
  • you have dementia
  • you have low blood levels of potassium, calcium and magnesium. Your doctor may perform blood tests to check on these
  • you are not eating properly or are very underweight
  • you have a history of alcohol problems
  • you have depression
  • you are diabetic or have high levels of sugar in your blood (hyperglycaemia). Your doctor may want to monitor you more closely.
  • you have abnormal muscle weakness (Myasthenia gravis)
  • you suffer from an enlargement of prostate gland (which will result in difficulty in passing water)
  • you are exposed to extremes in temperature as this medicine can affect body temperature control
  • you have an underactive thyroid gland
  • you are an elderly person
  • you or someone else in your family has a history of blood clots, as medicines like these have been associated with formation of blood clots

Stemetil Injection (Prochlorperazine Mesilate)

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. The effects of these medicines may change, especially if you are taking:

  • sleeping tablets or sedatives (e.g. phenobarbital) that can make you sleepy
  • medicines which result in lowering of blood pressure or treat migraine (e.g. guanethidine or clonidine)
  • anticholinergic medicines for stomach problems or used to reduce saliva and lung secretions (e.g. atropine, procyclidine)
  • antidepressants (e.g. other phenothiazines, lithium)
  • medicines for fits (anticonvulsants)
  • medicines for Parkinson’s disease (e.g. levodopa)
  • medicines for asthma or to relieve a stuffy nose or used in eye drops (adrenaline or sympathomimetic drugs)
  • medicines used to treat diabetes
  • medicines used to treat iron poisoning (desferrioxamine)
  • antacids used to treat indigestion.
  • medicines used to control heart beat such as propranolol.
  • medicines used for the treatment of cancer (cytotoxics).
  • medicines used for infection (antibiotics).
  • amfetamines used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Taking Prochlorperazine Injection with food and drink

You should not drink alcohol whilst you are taking this medicine.

Pregnancy and breast feeding

You should not be given Prochlorperazine Injection if you are pregnant, think you may be pregnant or are planning to become pregnant, or while breast feeding, unless your doctor decides that treatment is essential. It is particularly important not to take Prochlorperazine Injection during the first three months of pregnancy.

Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines

Prochlorperazine Injection may make you feel drowsy or dizzy or give you blurred vision. You should not drive or use machines when you are first given this medicine until you are certain that you are not getting these side effects. If in any doubt, speak to your doctor before you drive or use machines.

Important information about some of the ingredients of Prochlorperazine Injection

This medicinal product contains less than “Immol sodium (23mg) per dose, i.e. is essentially “sodium-free”.

This medicine also contains the preservatives sodium sulphite (E221) and sodium metabisulphite (E223) which may rarely cause severe hypersensitivity reactions and bronchospasm.


Prochlorperazine Injection is only given in the hospital by a doctor.

Prochlorperazine Injection is usually given by injection deep into the muscle. Your doctor will decide on a suitable dose depending on your age, severity of the symptoms and previous responses to similar medicines.

A smaller starting dose should be given to elderly patients.

Prochlorperazine Injection is not for use in children.

For mood disorders and schizophrenia, it may take several weeks for you to feel the full benefit of this medicine.

If you are given more Prochlorperazine Injection than you should:

As Prochlorperazine Injection is administered by a healthcare professional it is unlikely that you will be given too much. If you are at all concerned, speak to your doctor.

In this event, you will be treated in the hospital and you will be given the necessary treatment.

If you miss a dose of Prochlorperazine Injection

This is unlikely as the injection is given by a healthcare professional but if you are concerned about missing a dose, speak to your doctor.


Like all medicines, Prochlorperazine Injection can sometimes cause side effects, although not everybody gets them.

You should avoid:

  • exposure to direct sunlight (or sunbeds) if you are receiving a high dose of this medicine as it could cause your skin to over react to sunlight. Your doctor may advise you to use a sunblock.
  • getting the injection solution on your skin as it could cause a type of skin rash (dermatitis).

Some patients may experience a local lump at the site of injection, difficulty in sleeping, stuffy nose or dry mouth, agitation.

Tell your doctor straight away if you notice any of the following:

  • very rarely, patients may experience a fast or irregular heartbeat, constipation, difficulty or inability to pass urine or a high temperature.
  • rarely, Prochlorperazine Injection can lead to breast enlargement in men or to inappropriate milk production or altered menstrual cycle (e.g. periods stop) or lowered sexual performance.
  • occasionally, some patients have complained of feeling slowed down, whilst others of being agitated.
  • feeling weak or light-headed, especially just after standing up (this commonly occurs just after the injection has been administered).
  • a problem with your breathing.
  • very occasionally, medicines such as Prochlorperazine Injection can have effects on muscle control. If this happens, symptoms can include slurred speech, odd movements of the face, particularly of the tongue, eyes, head or neck (such as twisting of the neck which causes an unnatural positioning of the head, rigid muscles, tremors or restlessness and difficulty in sitting still. Some patients (especially on high doses of this medicine) experience problems with muscle control which may continue for years. Such patients may experience constant chewing or tongue movements or other gentle movements of the neck, head or trunk. Uncontrollable movements of the arms and legs have also been reported in these patients.
  • in elderly people with dementia, a small increase in the number of deaths has been reported for patients taking antipsychotics compared with those not receiving antipsychotics.
  • rarely patients may develop Neuroleptic Malignant Syndrome. This causes a high temperature, rigid muscles, drowsiness, occasional loss of consciousness, and requires emergency admission to hospital for treatment.
  • if you have angina and your pain is getting worse.
  • there have been very rare reports of jaundice (yellowing of skin and whites of eyes) eye problems, skin colouring (pigmentation) and blood problems.
  • if you suffer from a sore throat, high fever, feel very tired, become pale, develop bruises and nose bleeds. Fever may occur 1-3 weeks after treatment. These may indicate blood problems developing as a result of using this medicine.
  • tremor, rigidity, slowed ability to start and continue movements, and impaired ability to adjust the body’s position.
  • high blood sugar (symptoms can include excessive thirst, passing large amounts of urine, weight loss and feeling very tired).
  • blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing. If you notice any of these symptoms seek medical advice immediately.

If any of the side effects become serious, or if you notice any side effects not listed in this post, please tell your doctor or pharmacist.


Keep out of the reach and sight of children.

Do not use Prochlorperazine Injection after the expiry date which is stated on the ampoule and carton.

Do not store above 25°C. Store in the original carton.

If only part of the solution is used, the remainder should be discarded.


The active substance in Prochlorperazine Injection is prochlorperazine mesilate.

Prochlorperazine Injection also contains anhydrous sodium sulphite (E221), sodium metabisulphite (E223) and ethanolamine in water for injections.

What Prochlorperazine Injection looks like and contents of the pack

Prochlorperazine Injection is a colourless or almost colourless sterile solution. Each 1ml of solution contains 12.5mg of prochlorperazine mesilate. The solution is presented in 1ml and 2ml clear glass ampoules.

Each carton contains either 5 or 10 ampoules.

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