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Cordarone

Generic name: Amiodarone

Brand names: Amiodarone, Alti-Amiodarone; Amiodarone Hydrochloride for Injection; Apo-Amiodarone; Dom-Amiodarone; Gen-Amiodarone; Novo-Amiodarone; PHL-Amiodarone; PMS-Amiodarone; Ratio-Amiodarone; Ratio-Amiodarone I.V.; Sandoz-Amiodarone; Braxan; Coedarone; Forken; Keritmon

 

Pharmacological Effects:

Class III antiarrhythmic drugs. Has antianginal and antiarrhythmic action. The drug noncompetitively blocks a-and b-adrenergic receptors. Reduces sinoatrial, atrial, and nodal conduction, without affecting the intraventricular conduction. Cordarone increases the refractory period and reduces the excitability of the myocardium. Slows conduction of excitation and lengthens the refractory period of additional atrioventricular pathways.

Indications:

  • Relief of attacks of paroxysmal tachycardia
  • Relief of episodes of paroxysmal ventricular tachycardia
  • Relief of episodes of paroxysmal supraventricular tachycardia with high frequency of contractions of the ventricles, especially against the background sinroma Wolff-Parkinson-White
  • Relief of paroxysmal and sustained forms of atrial fibrillation (atrial fibrillation) and atrial flutter

Dosing:

Tablets. Loading dose: can be taken in various schemes. In the hospital: an initial dose, divided into several stages, ranging from 600 – to 800 mg (to a maximum of 1200 mg) per day until a total dose of 10 grams (usually within 5-8 days). Outpatient: initial dose, divided into several stages, ranging from 600 mg to 800 mg a day to achieve a total dose of 10 g (generally within 10-14 days). Maintenance dose: 3 mg / kg body weight a day and can be in the range from 100 mg / day to 400 mg / day in single dose.

CORDARONE200mg

Solution for injection.

Intravenous infusion. The recommended loading dose for adults is 5 mg / kg body weight of the patient, should be introduced in 250 ml of 5% glucose solution over 20 minutes to 2 hours. Introduction may be repeated 2-3 times within 24 hours.

Intravenous injection.

The recommended dose for adults is 5 mg / kg and need to be injected for at least 3 minutes. Repeated injections need to be performed no earlier than 15 minutes after the first injection. For children older than 3 years, the recommended dose is 5 mg / kg.

Side effects:

  • Organs of view: the deposition of lipofuscin in the corneal epithelium
  • Dermatological reactions: may appear weak pigmentation in open areas of skin
  • Endocrine status: with long-term intake in rare cases may develop hypothyroidism
  • Cardiovascular system: the application of high doses of Cordarone, as well as in susceptible patients, may cause bradycardia, AV conduction delay, arterial hypotension
  • Isolated cases of peripheral neuropathy, tremor
  • Gastrointestinal tract and liver: rarely nausea, heaviness in the epigastrium, the violation of liver function

Contraindications:

Tablets.

  • Hypersensitivity to iodine and / or amiodarone
  • Sick sinus syndrome (sinus bradycardia, sinoatrial block)
  • Violations of atrioventricular and intraventricular conduction
  • Thyroid dysfunction (hypothyroidism, gipertirez)
  • Hypokalemia, cardiac failure (decompensation stage)
  • Pregnancy
  • The period of lactation
  • Children age (18 years) (efficacy and safety are not established)
  • Simultaneous treatment with MAO inhibitors
  • Interstitial lung disease

Solution for injection.

  • allergy to iodine or amiodarone
  • sinus bradycardia, sinoatrial heart block
  • sick sinus syndrome
  • in combination with medicines that can cause paroxysmal ventricular tachycardia
  • dysfunction of the thyroid gland
  • pregnancy, except in exceptional cases
  • breastfeeding
  • children under 3 years

Storage:

In a dry place with temperature under 30 C.

Warning:

Before using the medicine you need to consult with your doctor.

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