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Melperone Hydrochloride

Last updated on November 15th, 2021

Drug Approvals

(British Approved Name Modified, rINNM)

Synonyms: FG-5111; Flubuperone Hydrochloride; Melperona, hidrocloruro de; Methylperone Hydrochloride
BAN: Melperone Hydrochloride [BANM]
INN: Melperone Hydrochloride [rINNM (en)]
INN: Hidrocloruro de melperona [rINNM (es)]
INN: Melpérone, Chlorhydrate de [rINNM (fr)]
INN: Melperoni Hydrochloridum [rINNM (la)]
INN: Мелперона Гидрохлорид [rINNM (ru)]
Chemical name: 4´-Fluoro-4-(4-methylpiperidino)butyrophenone hydrochloride
Molecular formula: C16H22FNO,HCl =299.8
CAS: 3575-80-2 (melperone); 1622-79-3 (melperone hydrochloride)
ATC code: N05AD03
Melperone Hydrochloride


Melperone is a butyrophenone with general properties similar to those of haloperidol. It is given as the hydrochloride by mouth or by intramuscular injection for the management of psychoses such as schizophrenia and in disturbed behaviour doses are expressed as the hydrochloride. A usual oral dose is up to 400 mg daily in divided doses. In acute conditions it may be given intramuscularly in doses of 25 to 100 mg repeated to a usual maximum of 200 mg daily.

Cardiac arrhythmias.

Melperone has been reported to have class III electrophysiologic and antiarrhythmic activity but its clinical use as an antiarrhythmic would be limited by a high incidence of adverse effects. For a discussion of the cardiovascular effects of antipsychotics in general, see under Chlorpromazine.


References to the use of melperone in schizophrenia. It has been suggested that melperone should be considered as an atypical antipsychotic in view of the low incidence of extrapyramidal effects associated with its use.

Proprietary Preparations

Austria: Buronil Neurill

Belgium: Buronil

Czech Republic: Buronil

Denmark: Buronil

Finland: Buronil Melpax

Germany: Eunerpan Harmosin Mel-Puren Melneurin Melperomerck

Portugal: Bunil

Sweden: Buronil

Turkey: Buronon.

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