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Last updated on November 21st, 2021

Generic name: Mefloquine

Brand names: Lariam

Why is Lariam (Mefloquine) prescribed?

Lariam is used to prevent and treat malaria. This disease is wide spread in such countries as Southern Asia, South America, and Africa.

It is important to use bed nets, wear protective clothing, insect repellent when trying to prevent malaria. Regular laboratory tests and eye examinations (e.g., liver function tests) should be performed to monitor your condition.

Your doctor may prescribe this remedy for other purposes. Contact your physician if you want to know more about this drug.

Don’t stop treatment with Mefloquine earlier than it was prescribed by your physician even if you notice improvements of your condition. Stopping the medication too early may worsen your condition. Be careful about driving, doing dangerous tasks, operating machinery or climbing until you are aware how this drug affects you. Don’t drink alcohol. Always contact a medic before giving Mefloquine to a child.

Special precautions before taking Lariam (Mefloquine):

Inform your medical assistant if you have allergy to mefloquine, to quinidine or quinine, or if you have or had any other type of allergies.

Report to a doctor if you have or had the following conditions:

  • psychiatric disorders
  • seizure
  • liver problems
  • anxiety disorder
  • active or recent depression
  • heart problems
  • pregnancy or breast-feeding

How should you take Lariam (Mefloquine)?

Note: This remedy was prescribed to you only. Don’t share this medicament with others. Follow strictly your doctor’s prescription. Don’t take more or longer than your doctor recommended.

Usually Mefloquine is prescribed to take orally once per 7 days. In order to avoid problems with your stomach, take it with milk or food or as recommended by your physician. Also take it with a full glass of water. If you can not swallow the pill, crush it and mix with sugar water, water, milk.

Your physician will prescribe you the correct dose. If you give mefloquine to a child for the first time, vomiting may occur. If vomiting occurs within half an hour after taking the drug, give another dose. If vomiting occurs half an hour an hour after a dose, give a half-dose. Contact your doctor if vomiting continues.

Take the first dose 7 days before your trip if you are going to take this drug in order to prevent malaria. Take this drug as prescribed by your physician during the full course of treatment. Don’t forget to take it on the same day each week. You should keep taking this drug during a month after returning from the malaria area, Inform your physician promptly if you feel fever. Malaria is best treated if therapy is started early.

What should be done if I missed the dose?

Don’t miss your dose, take the remedy on a regularly scheduled basis.

In case you forgot to take the dose, take it at your earliest opportunity. Never double your dose if it is almost time for your next dose. Take only one dose at once.


Taking any medicine in large doses you can have serious consequences for your health. If you feel an overdose, contact your health care professional instantly.

In large doses, this remedy may cause the following conditions:

  • diarrhea
  • vomiting

Side effects:

  • fever
  • strange dreams, insomnia
  • ringing in the ears
  • lightheadedness
  • vomiting, nausea, diarrhea
  • stomach pain ,stomach upset
  • hair loss
  • drowsiness, dizziness, headache

Visit your physician as soon as possible if these symptoms persist or become severe.

More serious side effects:

  • loss of coordination
  • seizures
  • vision changes
  • slow, fast or irregular heartbeat
  • muscle pain
  • numbness and tingling of hands or feet

If any of the following highly unlikely, but serious side effects occur; call your medical assistant at once; you may need to stop using mefloquine and start another medication for malaria prevention:

  • hallucinations
  • mood changes
  • confusion
  • unexplained anxiety
  • depression (sometimes severe, including rare thoughts of suicide)
  • restlessness

Seek immediate medical attention if a serious allergy to this drug occurs .

Symptoms of a serious allergic reaction include:

  • swelling
  • trouble breathing
  • rash
  • severe dizziness
  • itching

This list of side effects may be not complete, others may occur. Inform your medical practitioners about all side effects you experience.


Don’t take Mefloquine together with the following drugs:

  • quinine
  • chloroquine
  • ziprasidone
  • halofantrine
  • artemether-lumefantrine
  • quinidine
  • live bacterial vaccines

This list of interactions may be not complete. Provide your medical practitioners entire list of medicines, herbs, dietary supplements or non-prescription drugs you take. Moreover tell them whether you drink alcohol, use illegal drugs or smoke. Particular items may interact with your drug.

How should Lariam (Mefloquine) be stored?

Mefloquine should be stored at room temperature, between 15 and 30 degrees C (59 and 86 degrees F), in a tightly closed container. Protect from moisture, direct heat, and light. Do not store in the bathroom or near a sink. Keep Mefloquine out of the reach of children and away from animals.

Warning: Before taking the drug you need to consult your doctor. The information contained in this article is not intended to cover all possible precautions, drug interactions, adverse effects, directions, uses, allergic reactions or warnings.

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