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Oxitropium Bromide

Drug Approvals

(British Approved Name, rINN)

Synonyms: Ba-253; Bromuro de oxitropio; Oksitropiumbromidi; Oxitropii Bromidum; Oxitropio, bromuro de; Oxitropiumbromid
BAN: Oxitropium Bromide
INN: Oxitropium Bromide [rINN (en)]
INN: Bromuro de oxitropio [rINN (es)]
INN: Oxitropium, Bromure d’ [rINN (fr)]
INN: Oxitropii Bromidum [rINN (la)]
INN: Окситропия Бромид [rINN (ru)]
Chemical name: 6,7-Epoxy-8-ethyl-3-[(S)-tropoyloxy]tropanium bromide; (3s,6R,7S,8r)-8-Ethyl-3-[(S)-tropoyloxy]-6,7-epoxytropanium bromide
Molecular formula: C19H26BrNO4 =412.3
CAS: 30286-75-0
ATC code: R03BB02
Read code: y01qo

Pharmacopoeias. In Europe.

European Pharmacopoeia, 6th ed. (Oxitropium Bromide). A white or almost white, crystalline powder. It exhibits polymorphism. Very soluble in water sparingly soluble in alcohol freely soluble in methyl alcohol practically insoluble in dichloromethane.

Oxitropium Bromide

Profile

Oxitropium bromide is a quaternary ammonium antimuscarinic with actions similar to those of ipratropium bromide, to which it is structurally related. It is used as a bronchodilator in the treatment of reversible airways obstruction, as in asthma and chronic obstructive pulmonary disease. Doses of 100 or 200 micrograms by inhalation from a metered-dose aerosol have been given 2 or 3 times daily. Oxitropium bromide may also be given as a nebulised solution in doses of 1.5 mg inhaled 2 or 3 times daily. Animal studies have shown reproductive toxicity with high doses of oxitropium, hence the recommendation that it should not be used during pregnancy.

Proprietary Preparations

Belgium: Oxivent

Finland: Ventox

France: Tersigat

Germany: Ventilat

Ireland.: Oxivent

Italy: Oxivent

Japan: Tersigan

UK: Oxivent

Venezuela: Tersigat

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