(British Approved Name, rINN)
Pharmacopoeias. In Europe.
European Pharmacopoeia, 6th ed. (Oxitropium Bromide). A white or almost white, crystalline powder. It exhibits polymorphism. Very soluble in water sparingly soluble in alcohol freely soluble in methyl alcohol practically insoluble in dichloromethane.
Oxitropium bromide is a quaternary ammonium antimuscarinic with actions similar to those of ipratropium bromide, to which it is structurally related. It is used as a bronchodilator in the treatment of reversible airways obstruction, as in asthma and chronic obstructive pulmonary disease. Doses of 100 or 200 micrograms by inhalation from a metered-dose aerosol have been given 2 or 3 times daily.
Oxitropium bromide may also be given as a nebulised solution in doses of 1.5 mg inhaled 2 or 3 times daily. Animal studies have shown reproductive toxicity with high doses of oxitropium, hence the recommendation that it should not be used during pregnancy.