Chlorphenamine Maleate

What Is Chlorphenamine Maleate?

Chlorphenamine maleate is an antihistamine medication used to treat various allergy symptoms. It works by blocking the action of histamine, a substance in the body involved in allergic reactions. By inhibiting histamine, chlorphenamine helps relieve symptoms such as sneezing, itching, watery eyes, and runny nose associated with allergies.

This medication is commonly used to alleviate hay fever symptoms (allergic rhinitis), allergic conjunctivitis, and other allergic reactions. It may also be used to manage symptoms of insect bites or stings and certain skin rashes.

Chlorphenamine can cause drowsiness and is often included in over-the-counter cold and allergy medications. Sometimes, it may be combined with decongestants to relieve nasal congestion.

As with any medication, following the recommended dosage and usage instructions provided by a healthcare professional or as indicated on the product label is essential. Awareness of potential side effects and interactions with other medications is also essential.

If you have allergies or are experiencing symptoms that you believe may be related to an allergy, it’s advisable to consult a healthcare provider for proper diagnosis and guidance on the most appropriate treatment options for your specific situation.

Pharmacokinetics

Chlorphenamine maleate is absorbed relatively slowly from the gastrointestinal tract, with peak plasma concentrations occurring about 2.5 to 6 hours after oral doses. Bioavailability is low, with values of 25 to 50% having been reported. Chlorphenamine appears to undergo considerable first-pass metabolism. About 70% of chlorphenamine in the circulation is bound to plasma proteins. There is wide interindividual variation in the pharmacokinetics of chlorphenamine values ranging from 2 to 43 hours have been reported for the half-life. Chlorphenamine is widely distributed in the body and enters the CNS.

Chlorphenamine maleate is extensively metabolized. Metabolites include desmethyl- and desmethyl chlorphenamine. Unchanged drugs and metabolites are excreted primarily in the urine; excretion depends on urinary pH and flow rate. Only trace amounts have been found in the feces.

A duration of action of 4 to 6 hours has been reported. This is shorter than may be predicted from pharmacokinetic parameters.

More rapid and extensive absorption, faster clearance, and a shorter half-life have been reported in children.

Uses and Administration

Chlorphenamine maleate, an alkylamine derivative, is a sedating antihistamine that causes moderate sedation. It also has antimuscarinic activity. Chlorphenamine is a racemic mixture of the dextrorotatory isomer dexchlorpheniramine, which has about twice the activity of chlorphenamine by weight. Chlorphenamine maleate and dexchlorpheniramine maleate are used for the symptomatic relief of allergic conditions, including urticaria and angioedema, rhinitis, and conjunctivitis, and in pruritic skin disorders. They are common ingredients of compound preparations for symptomatic treatment of coughs and the common cold. However, such preparations should be used with caution in children and generally avoided in those under two years of age.

Chlorphenamine may be given intravenously as an adjunct in the emergency treatment of anaphylactic shock. Chlorphenamine maleate is given in oral doses of 4 mg every 4 to 6 hours up to a maximum of 24 mg daily. Doses for children, according to age, are 1 to 2 years, 1 mg twice daily for 2 to 5 years, 1 mg every 4 to 6 hours (maximum 6 mg daily) for 6 to 12 years, 2 mg every 4 to 6 hours (maximum 12 mg daily). Although not licensed in the UK, the BNFC suggests that children aged one month and over may be given 1 mg twice daily. Chlorphenamine maleate may be given by intramuscular, subcutaneous, or slow intravenous injection for 1 minute.

The usual dose is 10 to 20 mg, and the total dose given by these routes in 24 hours should be at most 40 mg. For children, doses of 87.5 micrograms/kg subcutaneously four times daily have been suggested. The following parenteral doses may also be used in children: the usual dose in those aged one month to 1 year is 250 micrograms/kg. Those aged 1 to 5 years may be given a dose of 2.5 to 5 mg, and those aged 6 to 12 years, 5 to 10 mg. Alternatively, children and adolescents aged 1 to 18 years may be given a dose of 200 micrograms/kg. The BNFC suggests that doses for children may be repeated, if necessary, up to 4 times in 24 hours.

Dexchlorpheniramine maleate is given in oral doses of 2 mg every 4 to 6 hours up to a maximum of 12 mg daily. Children aged 2 to 5 years may be given 0.5 mg every 4 to 6 hours (maximum 3 mg daily) and for those aged 6 to 12 years, 1 mg every 4 to 6 hours (maximum 6 mg daily).

Modified-release oral preparations of chlorphenamine maleate or dexchlorpheniramine maleate are available in some countries, and the dosage is specific to a particular formulation.

Dexchlorpheniramine maleate has been applied topically in some countries, although, as with other antihistamines, there is a risk of sensitization. Chlorphenamine polistirex (a sulfonated diethenylbenzene-ethenylben-zene copolymer complex), chlorphenamine tannate, and dexchlorpheniramine tannate are given orally and are used similarly to the maleate.

Malaria

Chlorphenamine may be tried in patients with malaria who have chloroquine-induced pruritus. Still additionally, it has been shown to have some promise as an adjunct in the treatment of chloroquine-resistant malaria itself. Early studies indicated that chlorphenamine was only one of some drugs that reversed chloroquine resistance in vitro in isolates of Plasmodium falciparum. Later clinical studies in children in Nigeria showed enhanced efficacy when chlorphenamine was given with chloroquine. The overall management of malaria is discussed.

Adverse Effects and Precautions

As for the sedating antihistamines in general. Exfoliative dermatitis may develop as a side effect. Injections may be irritant and cause transient hypotension or stimulation of the CNS.

Effects on the Blood

There are several old and isolated reports of blood dyscrasias after the use of chlorphenamine maleate. These include agranulocytosis, thrombocytopenia, pancytopenia, and aplastic anemia. Hemolytic anemia has occurred after the use of dexchlorpheniramine maleate. The association with antihistamine use has been questioned in some of these cases.

Effects on the Senses

Chlorphenamine has been reported to affect the senses of smell and taste.

Extrapyramidal Disorders

Facial dyskinesias have been reported after oral doses of chlorphenamine maleate.

Interactions

Chlorphenamine maleate can interact with other medications, substances, or medical conditions. It’s crucial to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, as well as any medical conditions you may have. Some potential interactions with chlorphenamine maleate include:

1. Central Nervous System Depressants: Chlorphenamine can enhance the sedative effects of other central nervous system depressants, such as alcohol, benzodiazepines, and certain sleep medications. This can increase the risk of drowsiness and impairment.
2. Monoamine Oxidase Inhibitors (MAOIs): Combining chlorphenamine with MAOIs, a class of antidepressants, can lead to serious side effects, including hypertensive crisis. It’s essential to wait a specific period after discontinuing an MAOI before starting chlorphenamine.
3. Anticholinergic Medications: Concurrent use of medications with anticholinergic effects (drugs that block acetylcholine, a neurotransmitter) may increase the risk of side effects like dry mouth, blurred vision, constipation, and urinary retention.
4. Certain Antifungal Medications: Some antifungal medications, particularly azole antifungals, may interact with chlorphenamine, affecting its metabolism and increasing the risk of side effects.
5. Other Medications That Cause Drowsiness: Combining chlorphenamine with other medications that cause drowsiness can result in additive effects, increasing the risk of excessive sedation.
6. Medical Conditions: Inform your healthcare provider if you have conditions such as glaucoma, prostate problems, urinary retention, or any other health issues, as these may be affected by chlorphenamine.

Always follow your healthcare provider’s advice and dosage recommendations. If you experience any unusual side effects or concerns about interactions, consult your healthcare provider promptly. This information is incomplete, and specific interactions can vary depending on individual circumstances.

Drug Approvals

(British Approved Name Modified, rINNM)

Synonyms: Chlorfenamin-maleinát; Chlorfenamino maleatas; Chlorphenamini Maleas; Chlorpheniramine Maleate; Chlorprophenpyridamine Maleate; Clorfenamina, maleato de; Klórfenamin-maleát; Kloorifenamiinimaleaatti; Klorfenaminmaleat

BAN: Chlorphenamine Maleate [BANM]

INN: Chlorphenamine Maleate [rINNM (en)]

INN: Maleato de clorfenamina [rINNM (es)]

INN: Chlorphénamine, Maléate de [rINNM (fr)]

INN: Chlorphenamini Maleas [rINNM (la)]

INN: Хлорфенамина Малеат [rINNM (ru)]

Chemical name: (±)-3-(4-Chlorophenyl)-NN-dimethyl-3-(2-pyridyl)propylamine hydrogen maleate

Molecular formula: C16H19ClN2,C4H4O4 =390.9

CAS: 132-22-9 (chlorphenamine); 113-92-8 (chlorphenamine maleate)

ATC code: R06AB04

Read code: y01tg

Pharmacopoeias. In China, Europe, Int., Japan, US

European Pharmacopoeia, 6th ed. (Chlorphenamine Maleate). A white or almost white crystalline powder. Freely soluble in water, soluble in alcohol. Protect from light.

The United States Pharmacopeia 31, 2008 (Chlorpheniramine Maleate). A white, odorless, crystalline powder. Soluble 1 in 4 of water and 1 in 10 of alcohol and chloroform, slightly soluble in ether and benzene. Its solutions in water have a pH between 4 and 5. Store in airtight containers. Protect from light.

Incompatibility. Chlorphenamine maleate has been reported to be incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium, and meglumine adipiodone.

Dexchlorpheniramine Maleate

Drug Approvals

(British Approved Name Modified, rINNM)

Synonyms: Dekschlorfeniramino maleatas; Dekskloorifeniramiinimaleaatti; Dexchlorfeniramin-maleinát; Dexchlorphenamine Maleate; Dexchlorpheniramini Maleas; Dexclorfeniramina, maleato de; Dexklórfeniramin-maleát; Dexklorfeniraminmaleat

BAN: Dexchlorpheniramine Maleate [BANM]

INN: Dexchlorpheniramine Maleate [rINNM (en)]

INN: Maleato de dexclorfeniramina [rINNM (es)]

INN: Dexchlorphéniramine, Maléate de [rINNM (fr)]

INN: Dexchlorpheniramini Maleas [rINNM (la)]

INN: Дексхлорфенирамина Малеат [rINNM (ru)]

CAS: 25523-97-1 (dexchlorpheniramine); 2438-32-6 (dexchlorpheniramine maleate)

ATC code: R06AB02

Pharmacopoeias. In Europe, Japan, and US.

European Pharmacopoeia, 6th ed. (Dexchlorpheniramine Maleate). A white or almost white crystalline powder. Very soluble in water, freely soluble in alcohol, dichloromethane, and methyl alcohol. A 1% solution in water has a pH of 4.5 to 5.5. Protect from light.

The United States Pharmacopeia 31, 2008 (Dexchlorpheniramine Maleate). A white, odorless, crystalline powder. Soluble 1 in 1.1 water, 1 in 2 of alcohol, 1 in 1.7 of chloroform, and 1 in 2500 of ether slightly soluble in benzene. The pH of a 1% solution in water is between 4.0 and 5.0. Store in airtight containers. Protect from light.

Preparations

BP2008: Chlorphenamine Injection Chlorphenamine Oral Solution Chlorphenamine Tablets

The United States Pharmacopeia 31, 2008: Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride Extended-release Capsules; Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride Extended-release Tablets; Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Extended-release Capsules; Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Oral Solution; Chlorpheniramine Maleate Extended-release Capsules; Chlorpheniramine Maleate Injection; Chlorpheniramine Maleate Syrup; Chlorpheniramine Maleate Tablets; Dexchlorpheniramine Maleate Syrup; Dexchlorpheniramine Maleate Tablets.

Proprietary Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Afeme; Alergidryl; Alergitrat; Isomerine¤; Qura Plus;
Australia: Allergex¤; Piriton¤; Polaramine;
Austria: Polaramin; Polaronil¤; Belgium: Bronchalene¤; Polaramine;
Brazil: Alergonil; Alergovalle; Alergyo; Alermine; Deflux; Dexclor; Dexlerg; Dexmin; Histamin; Hystin; Polamin; Polaramine; Polaren;
Canada: Chlor-Tripolon; Histalon¤; Novo-Pheniram; Polaramine¤;
Chile: Asafen Nueva Formula¤; Clorprimeton; Nipolen; Prodel; Scadan;
Denmark: Polaramin;
France: Polaramine;
Germany: Polaronil;
Greece: Istamex; Polaramine¤;
Hong Kong: Apomin; Chlorpyrimine; Dapriton; Medifen; Pirimat; Piriton¤; Polaramine; Rhiniramine; Sprinsol¤; Uni-Ramine;
Ireland: Anti-Hist¤; Piriton;
Israel: Ahiston; Anaphyl;
Italy: Clorten¤; Lentostamin¤; Polamin¤; Polaramin; Trimeton;
Malaysia: Chloramine; Chlorpyrimine; D-Antihist¤; Dex-Antihist¤; Dexchloramine; Polamine¤; Polaramine; Somin;
Mexico: Alerdil; Antadex-H; Blendox; Cloro-Trimeton; Cronal; Hierbal; Histadryl; Polaramine¤;
Netherlands: Methyrit¤; Polaramine;
Norway: Phenamin; Polaramin;
New Zealand: Histafen; Polaramine; Portugal: Trenelone;
South Africa: Allergex; Allerhist¤; Chlor-Trimeton¤; Chlorhist¤; Histamed¤; Polaramine; Rhineton;
Singapore: Allerphen¤; Chlorpyrimine; Piriton; Polaramine; Rhiniramine; Somin¤;
Spain: Antihista¤; Antihistaminico; Polaramine;
Sweden: Polaramin; Switzerland: Polaramine;
Thailand: Allergin; Chlorleate; Chlorpheno; Chlorpyrimine; Cohistan; Histatapp; Icolid Plus; Kloramin; Nasamine¤; Piriton;
United Arab Emirates: Chlorohistol;
United Kingdom: Allergy Relief; Allerief; Alunex¤; Calimal; Hayleve; Piriject¤; Piriton; Pollenase Antihistamine; Rimarin¤;
United States: Aller-Chlor; Allergy Relief; Allergy; Chlo-Amine; Chlor-Pro; Chlor-Trimeton; Chlor¤; Chlorate¤; Chlorspan¤; Chlortab¤; Dexchlor¤; Diabetic Tussin Allergy Relief¤; Ed-Chlor-Tan; Efidac 24 Chlorpheniramine; Gen-Allerate¤; PediaCare Allergy Formula; Pfeiffer’s Allergy¤; Phenetron¤; Poladex¤; Polaramine¤; QDALL AR; Ricobid H¤; Telachlor¤; Teldrin;
Venezuela: Clorotrimeton; Inquiramin; Liramin

Multi-ingredient Preparations

Canada: Alka-Seltzer Plus Cold¤; Allergy Sinus; Ana-Kit¤; Benylin Cold¤; Bronchodex D¤; Buckley’s Cough, Cold & Flu Nighttime Relief; Childrens NyQuil; Chlor-Tripolon Decongestant¤; Chlor-Tripolon Decongestant; Cold Decongestant¤; Cold Medication N; Cold Medication Nighttime Relief¤; Contac Cold¤; Contac Cough Cold and Flu¤; Coricidin D¤; Coricidin Sinus Headache¤; Coricidin with Codeine¤; Coricidin; Corsym¤; Dimetapp Nighttime Cold; Dristan¤; Dristan; Extra Strength Allergy Sinus; Extra Strength Cold Medication Nightime; Extra Strength Cold Medication Nighttime Relief¤; Formula 44M Pediatric¤; Formula 44M¤; Formule 115 DM¤; Jack & Jill Cough Cold & Flu; Jack & Jill DM; Junior Strength Cold DM¤; Metreton¤; Nasal & Sinus Cold Formula¤; Neo Citran Cough Cold & Flu; Neo Citran Sore Throat & Cough; Neo-Tuss; Novahistex¤; Omni-Tuss¤; Ornade Expectorant¤; Ornade-DM¤; Ornade¤; Penntuss¤; Regular Strength Cold Nighttime Relief; Relievol Allergy Sinus; Sedatuss¤; Sine-Off Allergy¤; Sinutab Extra Strength; Sinutab Sinus & Allergy; Sinutab with Codeine; TheraFlu Flu, Cold & Cough¤; Triaminic Cold & Allergy; Triaminic Cold & Cough; Triaminic Cold & Nightime Cough; Triaminic Cough & Cold; Triaminic Cough & Fever; Triaminic DM Expectorant¤; Triaminic DM Nighttime¤; Triaminic Expectorant¤; Triaminic Nighttime Flu¤; Triaminicol DM¤; Tuss-Ornade¤; Tussi-Organidin¤; Tylenol Allergy Sinus (Multi-Symptom Relief); Tylenol Cold & Flu (Nighttime Relief); Tylenol Cold (Nighttime); Tylenol Cold and Flu Powder; Tylenol Cold Children’s; Tylenol Cold DM; Tylenol Cold Infant’s; Tylenol Cold Medication¤; Vasofrinic Plus; Vasofrinic; Vick’s Children’s Liquid Nighttime Colds Medicine¤;

France: Arpha¤; Broncalene Nourisson; Broncalene; Broncorinol etats grippaux¤; Celestamine; Hexapneumine Compose¤; Hexapneumine; Hexapneumine; Hexapneumine; Humex Rhume; Hyrvalan¤; Pneumopan; Polaramine Pectoral¤; Propofan¤; Quintopan¤; Rhinofeb¤; Rhinofebral; Rumicine¤; Sup-Rhinite¤;

Germany: Balkis¤; Celestamine¤; Cimporhin¤; Codicaps B¤; Codicaps¤; Contac H¤; Contac¤; Grippostad C; Ornatos N¤; Ornatos¤; rhinicept¤; Sedotussin plus; sulfopecticept¤;

India: Alex Cough; Alex Paediatric; Alex-P; Alex; Ambrodil Plus; Andre; Ascoril-C; Cadicoff; Cheston CS; Cheston DT; Cheston; Cinaryl; Codylex Plus; Codylex; Cof Q; Cof QD; Cofdex Forte; Cofdex Forte; Cofdex Plus; Cofton SF; Cofton; Coldoff; Corex Dx; Corex; Cosome; Deacos; Dristan Expectorant; Dristan Expectorant; Exiplon; Gocold; Grilinctus; Grilinctus; Hepasulfol-AA; Lexcof; Mit’s Linctus Codeinae Co; Nicip Cold; Nocold Plus; Nocold; Nomokof; Ocurest-AH; Paracip CPM; Phensedyl; Piriton Expectorant; Protussa; Ralcidin; Rexcof Plus; Rexcof; Ridcof; Rinostat; Salyzine; Sedosolvin; Sinarest Linctus; Sinarest; Sinarest; Sinarest; Toff MD; Tossex-S; Tossex; Triaminic; Tuspress; Unicarbazan;

Ireland: Contac¤; Dristan¤; Expulin Childrens Cough; Expulin;

Israel: Acamol Tsinun Night; Acamoli Cold; Ahiston Compound; Alcinal New; Alcinal Plus; Alcinal; Coldex; Dexamol Cold Night; Dexamol Sinus Night; Histadex; Nussidex; Paramol AF and Shiul Night; Paramol AF Night;

Italy: Antiflu; Baby-Rinolo; Dirahist; Durazina¤; Femidol¤; Fienamina; Fluororinil; Iodosan Raffreddore Contac¤; Ischemol A; Neo Coricidin; Polaramin Espettorante; Raffreddoremed; Rectocoricidin¤; Rinofrenal; Rinogutt Antiallergico Spray; Tempo-Rinolo¤; Triaminic; Visuglican; Visumetazone Antistaminico; Zerinetta-Fher¤; Zerinetta; Zerinoflu; Zerinol-Fher;

Russia: Antiflu (Антифлу); Coldact Broncho (Колдакт Бронхо); Coldact Flu Plus (Колдакт Флю Плюс); Grippostad C (Гриппостад С); Rinza (Ринза); Spain: Alergical Expect; Alergical; Alergical; Anticatarral; Aspirina Complex; Baby Rinol¤; Bisolgrip; Blapidon Vitaminado¤; Calmagrip; Celesemine; Colnidin; Coricidin Fuerte¤; Coricidin; Cortafriol Complex; Couldina C; Couldina Instant; Couldina; Cromoftol¤; Desenfriol C; Desenfriol D; Desenfriol Infantil¤; Desenfriol; Dristan¤; Durasina¤; Elingrip¤; Farmagripine¤; Fludren; Fluxal¤; Frenadol Complex; Frenadol PS; Frenadol; Frenal Rinologico¤; Frenaseltz; Gripakin; Gripofren¤; Grippal; Hem Anth; Hubergrip¤; Lasa Con Codeina; Liderplus¤; Meridol¤; Miferen¤; Novag Grip; Oberdol¤; Oportunin¤; Paidoterin Descongestivo NF; Pectoral Funk Antitus¤; Pharmagrip; Plivamol; Polaramine Expectorante; Polaramine Topico; Pridio; Propalgina Plus; Respritin¤; Rhinospray Antialergico; Rimagrip; Rino Dexa; Rinofol¤; Rinofrenal Plus; Rinomicine Activada; Rinomicine; Rinomicine; Rynatan¤; Seniospray; Sinutab¤; Spirsa¤; Tilfilin¤; Vincigrip; Yendol;

Switzerland: Benical; Brustol¤; Celestamine; Contac Rhume¤; Contac Toux¤; Dextrolag¤; Hustex¤; Influbene¤; Migraine-Kranit; Natuscap retard¤; Patussol¤; Pecto-Baby; Rhinofebral; Sine-Off¤; Solmucalm; Triocaps; Tussiplex;

United Kingdom: Dristan¤; Expulin Childrens Cough¤; Expulin Decongestant¤; Expulin¤; Expurhin¤; Galpseud Plus; Haymine; Lemsip Night Time¤; Sine-Off¤; Tixylix Cough & Cold; Triolinctus¤;

United States: 12 Hour Cold¤; 4-Way Cold Tablets¤; Accuhist LA; Aclophen; Advil Allergy Sinus; AeroHist Plus; AeroKid; AH-chew; Aler-Releaf¤; Alersule¤; Alka-Seltzer Plus Cold & Cough¤; Alka-Seltzer Plus Cold & Cough; Alka-Seltzer Plus Cold¤; Alka-Seltzer Plus Cold; Alka-Seltzer Plus Nose & Throat; Allerest 12 Hour¤; Allerest Headache Strength; Allerest Maximum Strength; Allerest Sinus Pain Formula; Allergy Relief Medicine¤; AlleRx; AlleRx; Alumadrine¤; Amerifed; Amerituss AD; Ana-Kit; Anamine¤; Anaplex¤; ARM¤; Aspirin-Free Bayer Select Allergy Sinus; Atrohist Pediatric¤; Atrohist Plus¤; Atuss DM; Atuss HC; Atuss HD; Atuss-12 DM; Bayer Select Flu Relief; BC Multi Symptom Cold Powder¤; Bellahist-D; Biohist-LA; Brexin LA¤; Bronkotuss Expectorant; Ceron-DM; Ceron; Cerose DM; Children’s Allerest¤; Children’s CoTylenol¤; Chlor-Mes D; Chlor-Mes Jr; Chlor-Rest¤; Chlor-Trimeton 12 Hour Relief; Chlor-Trimeton 4 Hour Relief; Chlor-Trimeton Allergy Sinus¤; Chlorafed; Chlordex GP; Chlordrine; Chlorex-A; Chlorgest-HD¤; Chlorphedrine SR; Co-Apap; Co-Hist; Co-Pyronil¤; Codehist DH; Codimal LA¤; Codimal¤; Cold Max¤; Cold Relief¤; Cold Tablets-D¤; Cold Tablets¤; Colfed-A; Comhist LA; Comtrex Allergy-Sinus; Comtrex Day & Night Maximum Strength; Comtrex Day & Night Multi-Symptom; Comtrex Day/Night Flu Therapy; Comtrex Hot Flu Relief; Comtrex Liqui-Gels¤; Comtrex Maximum Strength Night-time Cold & Cough; Comtrex Sinus & Nasal Decongestant; Comtrex; Condrin-LA¤; Congestant D¤; Congestant; Contac 12 Hour¤; Contac Maximum Strength 12 Hour¤; Contac Severe Cold & Flu Hot Medicine¤; Contac Severe Cold & Flu Nighttime¤; Contac Severe Cold and Flu Formula¤; Cophene No. 2; Cordron-HC; Corfen-DM; Coricidin D¤; Coricidin Maximum Strength Sinus Headache¤; Coricidin; Covangesic¤; CP Tannic; CPM PSE MSC; CPM/PE/MSC; Cyndal HD; Cytuss HC; DA Chewable; DA II; Dallergy-D; Dallergy-D; Dallergy-JR; Dallergy; Dapacin Cold¤; De-Chlor DM; De-Chlor DR; De-Chlor HC; De-Chlor HD; Decohistine DH; Deconamine; Decongestabs¤; Decongestant SR¤; Decongestant¤; Decongestant; Deconhist LA¤; Deconomed; Dehist¤; Dehistine; Demazin¤; Derma-Pax; DiHydro-CP; Donatussin; Donatussin; Dorcol Children’s Cold Formula; DriHist; Dristan Cold & Flu; Dristan Cold Multi-Symptom Formula; Dristan Cold; Drize¤; Duadacin Extra Strength Cold & Flu¤; Duadacin¤; Dura-Tap/PD; Dura-Vent/A¤; Dura-Vent/DA; Durahist D; Durahist; Duralex; Ed A-Hist; ED Tuss HC; ED-TLC; Effective Strength Cough Formula; Endagen-HD; Endal-HD Plus; Ex-Histine; Exratuss; Extendryl; Extra Strength Pyrroxate¤; Father John’s Medicine Plus; Fedahist Decongestant¤; Fedahist¤; Flu, Cold & Cough Medicine; Gelhist; Gelpirin-CCF¤; Genacol; Genamin¤; Gencold¤; Gendecon; Hayfebrol; HC Derma-Pax; Hista-Vadrin¤; Hista-Vent DA; Histabid¤; Histade¤; Histadyl and ASA¤; Histafed¤; Histagesic Modified; Histalet Forte¤; Histalet; Histaspan-D¤; Histatab Plus; Histex SR; Histex; Histinex HC; Histinex PV; Histor-D Timecelles; Histor-D; Histussin HC; Hycomine Compound; Hydex PD; Hydro PC; Hydrocodone CP; Hydrocodone HD; Hydron CP; Hydron PSC; Hyphed; HyTan; Iodal; Iotussin HC; Isoclor¤; Kid Kare Childrens Cough/Cold; Kisitan¤; Klerist-D; Kolephrin/DM; Kolephrin; Kophane Cough and Cold Formula¤; Kronofed-A; Lemotussin-DM; Mapap Cold Formula; Maxi-Tuss HCX; Meda Syrup Forte¤; Medatussin Plus¤; Medi-Flu¤; Mescolor¤; Myfedrine Plus¤; Myminic Syrup¤; Myminicol¤; N D Clear; Naldec Pediatric¤; Naldecon¤; Nalex-A 12; Nalex-A; Nalgest¤; Nalspan Pediatric¤; Napril¤; Nasatuss¤; ND-Gesic; New Acute Cold Formula¤; New Decongestant Pediatric¤; Nolamine¤; Norel DM; Norel Plus¤; Norel SD; Notuss PD; Novafed A; Novahistine DH; Novahistine¤; Nuhist; Omnihist LA; Ornade¤; Orthoxicol Cough¤; P-V-Tussin; Panatuss DX; Pancof PD; Pancof-HC; Pancof; Pannaz; Par Decon¤; Para-Hist HD; Parhist SR¤; PCM; PediaCare Childrens Cold & Allergy; PediaCare Childrens Multi-Symptom Cold; Pediacare Cold Formula¤; PediaCare Cough-Cold; PediaCare NightRest Cough-Cold Formula; Pediacof; Pediox; Pedituss Cough; Penntuss¤; Phena-Chlor¤; Phenacon¤; Phenahist-TR¤; Phenapap Sinus Headache & Congestion; Phenate¤; Phenchlor SHA¤; Phenhist DH with Codeine; Polaramine Expectorant; Poly-Tussin; Prehist D; Prehist; Primatuss Cough Mixture 4; Probahist¤; Protid; PSE CPM; Pseudo-Chlor; Pseudo-Gest Plus; QDALL; Quadra Hist¤; Quelidrine; R-Tanna S Pediatric; R-Tanna; R-Tannamine; R-Tannate; Ralix; Relacon-HC; Remcol Cold¤; Remcol-C¤; Rentamine Pediatric; Resaid¤; Rescon-DM; Rescon-ED¤; Rescon-Jr; Rescon-MX; Rescon¤; Respa-ARM¤; Rhinatate-NF; Rhinatate; Rhinogesic¤; Rhinolar-EX¤; Rhinolar¤; Rhinosyn-DM; Rhinosyn; Ricobid¤; Rinade BID¤; Robitussin PM Cough & Cold; Rolatuss Expectorant; Rolatuss Plain; Ru-Tuss II¤; Ru-Tuss¤; Ry-Tuss; Ryna-C¤; Ryna¤; Rynatuss; Ryneze; S-T Forte 2; Salphenyl¤; Scot-Tussin Cough & Cold Medicine¤; Scot-Tussin DM; Silaminic Cold¤; Simplet; Sinapils¤; Sinarest; Sine-Off Maximum Strength Allergy/Sinus; Sine-Off Sinus Medicine¤; Singlet; Sinulin¤; Sinutab Maximum Strength Sinus Allergy; Sinutrex Extra Strength¤; Snaplets-D¤; Snaplets-Multi¤; Spray-ur-Cold¤; Stahist; Sudafed Cold & Allergy; Sudafed Plus; Super Cold Tabs¤; Super Strength Sinadrin¤; T-Dry¤; T-Koff¤; Tanafed DM¤; Tanafed DMX; Tanafed DP; Tanafed¤; Tannic-12; Tanoral; Temazin Cold¤; Thera-Hist¤; TheraFlu Flu and Cold; TheraFlu Flu, Cold & Cough; TheraFlu Severe Cold; Threamine DM¤; Tri-Clear¤; Tri-Nefrin Extra Strength¤; Tri-Phen-Chlor TR¤; Tri-Tannate Plus Pediatric; Tri-Tannate; Triactin¤; Triaminic Allergy¤; Triaminic Chewable¤; Triaminic Cold & Allergy; Triaminic Cold & Cough; Triaminic Cold¤; Triaminic Flu, Cough & Fever; Triaminic Night Time Cough & Cold; Triaminic Softchews; Triaminic-12¤; Triaminic¤; Triaminicin Cold, Allergy, Sinus¤; Triaminicol Multi-Symptom Cough and Cold¤; Triaminicol Multi-Symptom Relief¤; Tricodene Forte¤; Tricodene NN¤; Tricodene Sugar Free; Tricom¤; Triminol Cough¤; Trind¤; Triotann; Tripalgen Cold¤; Triphenyl¤; Tritan; Tusquelin¤; Tuss-Tan; Tussanil DH; Tussanil Plain; Tussar DM; Tussend; Tussi-12; Tussionex Pennkinetic; Tussizone; Ty-Cold¤; Tylenol Allergy Complete Multi-Symptom; Tylenol Allergy Sinus Day & Night; Tylenol Children’s Cold Plus Cough; Tylenol Children’s Cold; Tylenol Childrens Plus Cold Nighttime; Tylenol Cold Complete Formula; Tylenol Cold Effervescent¤; Uni-Decon¤; Unituss HC; Vanex Forte-R¤; Vanex Forte¤; Vanex Grape¤; Vanex-HD; Vicks 44M Cold, Flu & Cough LiquiCaps; Vicks Children’s NyQuil Allergy/Head Cold; Vicks Children’s NyQuil Night-time Cold/Cough Liquid; Vicks Pediatric Formula 44M Multi-Symptom Cough & Cold; Viro-Med¤; Xiral; Xiratuss; Z-Cof HC