Drug Approvals
(British Approved Name Modified, rINNM)
Pharmacopoeias. In China, Europe, Int., Japan, US
European Pharmacopoeia, 6th ed. (Chlorphenamine Maleate). A white or almost white, crystalline powder. Freely soluble in water soluble in alcohol. Protect from light.
The United States Pharmacopeia 31, 2008 (Chlorpheniramine Maleate). A white, odourless, crystalline powder. Soluble 1 in 4 of water and 1 in 10 of alcohol and of chloroform slightly soluble in ether and in benzene. Its solutions in water have a pH between 4 and 5. Store in airtight containers. Protect from light.
Incompatibility. Chlorphenamine maleate has been reported to be incompatible with calcium chloride, kanamycin sulfate, no-radrenaline acid tartrate, pentobarbital sodium, and meglumine adipiodone.
Dexchlorphemramine Maleate
Drug Approvals
(British Approved Name Modified, rINNM)
Pharmacopoeias. In Europe, Japan, and US.
European Pharmacopoeia, 6th ed. (Dexchlorphenirarnine Maleate). A white or almost white, crystalline powder. Very soluble in water freely soluble in alcohol, in dichloromethane, and in methyl alcohol. A 1% solution in water has a pH of 4.5 to 5.5. Protect from light.
The United States Pharmacopeia 31, 2008 (Dexchlorphenirarnine Maleate). A white, odourless, crystalline powder. Soluble 1 in 1.1 of water, 1 in2 of alcohol, 1 in 1.7 of chloroform, and 1 in 2500 of ether slightly soluble in benzene. pH of a 1% solution in water is between 4.0 and 5.0. Store in airtight containers. Protect from light.
Adverse Effects and Precautions
As for the sedating antihistamines in general. Exfoliative dermatitis may develop. Injections may be irritant and cause transient hypotension or stimulation of the CNS.
Effects on the blood.
There are several old and isolated reports of blood dyscrasias after use of chlorphenamine maleate these include agranulocytosis, thrombocytopenia, pancytope-nia, and aplastic anaemia. Haemolytic anaemia has occurred after use of dexchlorphenirarnine maleate. The association with antihistamine use has been questioned in some of these cases.
Effects on the senses.
Chlorphenamine has been reported to affect the senses of smell and taste.
Extrapyramidal disorders.
Facial dyskinesias have been reported after oral doses of chlorphenamine maleate.
Interactions
As for the sedating antihistamines in general.
Antiepileptics.
For a report of the effect of chlorphenamine on phenytoin.
Pharmacokinetics
Chlorphenamine maleate is absorbed relatively slowly from the gastrointestinal tract, peak plasma concentrations occurring about 2.5 to 6 hours after oral doses. Bioavailability is low, values of 25 to 50% having been reported. Chlorphenamine appears to undergo considerable first-pass metabolism. About 70% of chlorphenamine in the circulation is bound to plasma proteins. There is wide interindividual variation in the pharmacokinetics of chlorphenamine values ranging from 2 to 43 hours have been reported for the half-life. Chlorphenamine is widely distributed in the body, and enters the CNS.
Chlorphenamine maleate is extensively metabolised. Metabolites include desmethyl- and didesmethylchlo-rphenamine. Unchanged drug and metabolites are excreted primarily in the urine excretion is dependent on urinary pH and flow rate. Only trace amounts have been found in the faeces.
A duration of action of 4 to 6 hours has been reported this is shorter than may be predicted from pharmacokinetic parameters.
More rapid and extensive absorption, faster clearance, and a shorter half-life have been reported in children.
Uses and Administration
Chlorphenamine maleate, an alkylamine derivative, is a sedating antihistamine that causes a moderate degree of sedation it also has antimuscarinic activity. Chlorphenamine is a racemic mixture the dextrorotatory isomer, dexchlorphenirarnine, has about twice the activity of chlorphenamine by weight. Chlorphenamine maleate and dexchlorphenirarnine maleate are used for the symptomatic relief of allergic conditions including urticaria and angioedema, rhinitis, and conjunctivitis, and in pruritic skin disorders. They are common ingredients of compound preparations for symptomatic treatment of coughs and the common cold. However, such preparations should be used with caution in children, and generally avoided in those under 2 years of age.
Chlorphenamine maybe given intravenously as an adjunct in the emergency treatment of anaphylactic shock. Chlorphenamine maleate is given in oral doses of 4 mg every 4 to 6 hours up to a maximum of 24 mg daily. Doses for children, according to age, are: 1 to 2 years, 1 mg twice daily 2 to 5 years, 1 mg every 4 to 6 hours (maximum 6 mg daily) 6 to 12 years, 2 mg every 4 to 6 hours (maximum 12 mg daily). Although not licensed in the UK, the BNFC suggests that children aged 1 month and over may be given 1 mg twice daily. Chlorphenamine maleate may be given by intramuscular, by subcutaneous, or by slow intravenous injection over a period of 1 minute.
The usual dose is 10 to 20 mg and the total dose given by these routes in 24 hours should not normally exceed 40 mg. For children, doses of 87.5 micrograms/kg subcutaneously four times daily have been suggested. The following parenteral doses may also be used in children: the usual dose in those aged 1 month to 1 year is 250 micrograms/kg those aged 1 to 5 years may be given a dose of 2.5 to 5 mg and those aged 6 to 12 years, 5 to 10 mg. Alternatively, children and adolescents aged 1 to 18 years may be given a dose of 200 micrograms/kg. The BNFC suggests that doses for children may be repeated if necessary up to 4 times in 24 hours.
Dexchlorphenirarnine maleate is given in oral doses of 2 mg every 4 to 6 hours up to a maximum of 12 mg daily. Children aged 2 to 5 years may be given 0.5 mg every 4 to 6 hours (maximum 3 mg daily), and those aged 6 to 12 years, 1 mg every 4 to 6 hours (maximum 6 mg daily).
Modified-release oral preparations of chlorphenamine maleate or dexchlorphenirarnine maleate are available in some countries dosage is specific to a particular formulation.
Dexchlorphenirarnine maleate has been applied topically in some countries, although as with other antihistamines there is a risk of sensitisation. Chlorphenamine polistirex (a sulfonated diethenylbenzene-ethenylben-zene copolymer complex), chlorphenamine tannate, and dexchlorphenirarnine tannate are given orally and are used similarly to the maleate.
Malaria.
Chlorphenamine may be tried in patients with malaria who have chloroquine-induced pruritus (see Effects on the Skin), but additionally it has been shown to have some promise as an adjunct in the treatment of chloroquine-resistant malaria itself. Early studies indicated that chlorphenamine was only one of a number of drugs that reversed chloroquine resistance in vitro in isolates of Plasmodium falciparum. Later clinical studies in children in Nigeria showed enhanced efficacy when chlorphenamine was given with chloroquine. The overall management of malaria is discussed.
Preparations
BP2008: Chlorphenamine Injection Chlorphenamine Oral Solution Chlorphenamine Tablets
The United States Pharmacopeia 31, 2008: Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride Extended-release Capsules; Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride Extended-release Tablets; Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Extended-release Capsules; Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Oral Solution; Chlorpheniramine Maleate Extended-release Capsules; Chlorpheniramine Maleate Injection; Chlorpheniramine Maleate Syrup; Chlorpheniramine Maleate Tablets; Dexchlorpheniramine Maleate Syrup; Dexchlorpheniramine Maleate Tablets.
Proprietary Preparations
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
Argentina: Afeme; Alergidryl; Alergitrat; Isomerine¤; Qura Plus;
Australia: Allergex¤; Piriton¤; Polaramine;
Austria: Polaramin; Polaronil¤; Belgium: Bronchalene¤; Polaramine;
Brazil: Alergonil; Alergovalle; Alergyo; Alermine; Deflux; Dexclor; Dexlerg; Dexmin; Histamin; Hystin; Polamin; Polaramine; Polaren;
Canada: Chlor-Tripolon; Histalon¤; Novo-Pheniram; Polaramine¤;
Chile: Asafen Nueva Formula¤; Clorprimeton; Nipolen; Prodel; Scadan;
Denmark: Polaramin;
France: Polaramine;
Germany: Polaronil;
Greece: Istamex; Polaramine¤;
Hong Kong: Apomin; Chlorpyrimine; Dapriton; Medifen; Pirimat; Piriton¤; Polaramine; Rhiniramine; Sprinsol¤; Uni-Ramine;
Ireland: Anti-Hist¤; Piriton;
Israel: Ahiston; Anaphyl;
Italy: Clorten¤; Lentostamin¤; Polamin¤; Polaramin; Trimeton;
Malaysia: Chloramine; Chlorpyrimine; D-Antihist¤; Dex-Antihist¤; Dexchloramine; Polamine¤; Polaramine; Somin;
Mexico: Alerdil; Antadex-H; Blendox; Cloro-Trimeton; Cronal; Hierbal; Histadryl; Polaramine¤;
Netherlands: Methyrit¤; Polaramine;
Norway: Phenamin; Polaramin;
New Zealand: Histafen; Polaramine; Portugal: Trenelone;
South Africa: Allergex; Allerhist¤; Chlor-Trimeton¤; Chlorhist¤; Histamed¤; Polaramine; Rhineton;
Singapore: Allerphen¤; Chlorpyrimine; Piriton; Polaramine; Rhiniramine; Somin¤;
Spain: Antihista¤; Antihistaminico; Polaramine;
Sweden: Polaramin; Switzerland: Polaramine;
Thailand: Allergin; Chlorleate; Chlorpheno; Chlorpyrimine; Cohistan; Histatapp; Icolid Plus; Kloramin; Nasamine¤; Piriton;
United Arab Emirates: Chlorohistol;
United Kingdom: Allergy Relief; Allerief; Alunex¤; Calimal; Hayleve; Piriject¤; Piriton; Pollenase Antihistamine; Rimarin¤;
United States: Aller-Chlor; Allergy Relief; Allergy; Chlo-Amine; Chlor-Pro; Chlor-Trimeton; Chlor¤; Chlorate¤; Chlorspan¤; Chlortab¤; Dexchlor¤; Diabetic Tussin Allergy Relief¤; Ed-Chlor-Tan; Efidac 24 Chlorpheniramine; Gen-Allerate¤; PediaCare Allergy Formula; Pfeiffer’s Allergy¤; Phenetron¤; Poladex¤; Polaramine¤; QDALL AR; Ricobid H¤; Telachlor¤; Teldrin;
Venezuela: Clorotrimeton; Inquiramin; Liramin
Multi-ingredient Preparations
Canada: Alka-Seltzer Plus Cold¤; Allergy Sinus; Ana-Kit¤; Benylin Cold¤; Bronchodex D¤; Buckley’s Cough, Cold & Flu Nighttime Relief; Childrens NyQuil; Chlor-Tripolon Decongestant¤; Chlor-Tripolon Decongestant; Cold Decongestant¤; Cold Medication N; Cold Medication Nighttime Relief¤; Contac Cold¤; Contac Cough Cold and Flu¤; Coricidin D¤; Coricidin Sinus Headache¤; Coricidin with Codeine¤; Coricidin; Corsym¤; Dimetapp Nighttime Cold; Dristan¤; Dristan; Extra Strength Allergy Sinus; Extra Strength Cold Medication Nightime; Extra Strength Cold Medication Nighttime Relief¤; Formula 44M Pediatric¤; Formula 44M¤; Formule 115 DM¤; Jack & Jill Cough Cold & Flu; Jack & Jill DM; Junior Strength Cold DM¤; Metreton¤; Nasal & Sinus Cold Formula¤; Neo Citran Cough Cold & Flu; Neo Citran Sore Throat & Cough; Neo-Tuss; Novahistex¤; Omni-Tuss¤; Ornade Expectorant¤; Ornade-DM¤; Ornade¤; Penntuss¤; Regular Strength Cold Nighttime Relief; Relievol Allergy Sinus; Sedatuss¤; Sine-Off Allergy¤; Sinutab Extra Strength; Sinutab Sinus & Allergy; Sinutab with Codeine; TheraFlu Flu, Cold & Cough¤; Triaminic Cold & Allergy; Triaminic Cold & Cough; Triaminic Cold & Nightime Cough; Triaminic Cough & Cold; Triaminic Cough & Fever; Triaminic DM Expectorant¤; Triaminic DM Nighttime¤; Triaminic Expectorant¤; Triaminic Nighttime Flu¤; Triaminicol DM¤; Tuss-Ornade¤; Tussi-Organidin¤; Tylenol Allergy Sinus (Multi-Symptom Relief); Tylenol Cold & Flu (Nighttime Relief); Tylenol Cold (Nighttime); Tylenol Cold and Flu Powder; Tylenol Cold Children’s; Tylenol Cold DM; Tylenol Cold Infant’s; Tylenol Cold Medication¤; Vasofrinic Plus; Vasofrinic; Vick’s Children’s Liquid Nighttime Colds Medicine¤;
France: Arpha¤; Broncalene Nourisson; Broncalene; Broncorinol etats grippaux¤; Celestamine; Hexapneumine Compose¤; Hexapneumine; Hexapneumine; Hexapneumine; Humex Rhume; Hyrvalan¤; Pneumopan; Polaramine Pectoral¤; Propofan¤; Quintopan¤; Rhinofeb¤; Rhinofebral; Rumicine¤; Sup-Rhinite¤;
Germany: Balkis¤; Celestamine¤; Cimporhin¤; Codicaps B¤; Codicaps¤; Contac H¤; Contac¤; Grippostad C; Ornatos N¤; Ornatos¤; rhinicept¤; Sedotussin plus; sulfopecticept¤;
India: Alex Cough; Alex Paediatric; Alex-P; Alex; Ambrodil Plus; Andre; Ascoril-C; Cadicoff; Cheston CS; Cheston DT; Cheston; Cinaryl; Codylex Plus; Codylex; Cof Q; Cof QD; Cofdex Forte; Cofdex Forte; Cofdex Plus; Cofton SF; Cofton; Coldoff; Corex Dx; Corex; Cosome; Deacos; Dristan Expectorant; Dristan Expectorant; Exiplon; Gocold; Grilinctus; Grilinctus; Hepasulfol-AA; Lexcof; Mit’s Linctus Codeinae Co; Nicip Cold; Nocold Plus; Nocold; Nomokof; Ocurest-AH; Paracip CPM; Phensedyl; Piriton Expectorant; Protussa; Ralcidin; Rexcof Plus; Rexcof; Ridcof; Rinostat; Salyzine; Sedosolvin; Sinarest Linctus; Sinarest; Sinarest; Sinarest; Toff MD; Tossex-S; Tossex; Triaminic; Tuspress; Unicarbazan;
Ireland: Contac¤; Dristan¤; Expulin Childrens Cough; Expulin;
Israel: Acamol Tsinun Night; Acamoli Cold; Ahiston Compound; Alcinal New; Alcinal Plus; Alcinal; Coldex; Dexamol Cold Night; Dexamol Sinus Night; Histadex; Nussidex; Paramol AF and Shiul Night; Paramol AF Night;
Italy: Antiflu; Baby-Rinolo; Dirahist; Durazina¤; Femidol¤; Fienamina; Fluororinil; Iodosan Raffreddore Contac¤; Ischemol A; Neo Coricidin; Polaramin Espettorante; Raffreddoremed; Rectocoricidin¤; Rinofrenal; Rinogutt Antiallergico Spray; Tempo-Rinolo¤; Triaminic; Visuglican; Visumetazone Antistaminico; Zerinetta-Fher¤; Zerinetta; Zerinoflu; Zerinol-Fher;
Russia: Antiflu (Антифлу); Coldact Broncho (Колдакт Бронхо); Coldact Flu Plus (Колдакт Флю Плюс); Grippostad C (Гриппостад С); Rinza (Ринза); Spain: Alergical Expect; Alergical; Alergical; Anticatarral; Aspirina Complex; Baby Rinol¤; Bisolgrip; Blapidon Vitaminado¤; Calmagrip; Celesemine; Colnidin; Coricidin Fuerte¤; Coricidin; Cortafriol Complex; Couldina C; Couldina Instant; Couldina; Cromoftol¤; Desenfriol C; Desenfriol D; Desenfriol Infantil¤; Desenfriol; Dristan¤; Durasina¤; Elingrip¤; Farmagripine¤; Fludren; Fluxal¤; Frenadol Complex; Frenadol PS; Frenadol; Frenal Rinologico¤; Frenaseltz; Gripakin; Gripofren¤; Grippal; Hem Anth; Hubergrip¤; Lasa Con Codeina; Liderplus¤; Meridol¤; Miferen¤; Novag Grip; Oberdol¤; Oportunin¤; Paidoterin Descongestivo NF; Pectoral Funk Antitus¤; Pharmagrip; Plivamol; Polaramine Expectorante; Polaramine Topico; Pridio; Propalgina Plus; Respritin¤; Rhinospray Antialergico; Rimagrip; Rino Dexa; Rinofol¤; Rinofrenal Plus; Rinomicine Activada; Rinomicine; Rinomicine; Rynatan¤; Seniospray; Sinutab¤; Spirsa¤; Tilfilin¤; Vincigrip; Yendol;
Switzerland: Benical; Brustol¤; Celestamine; Contac Rhume¤; Contac Toux¤; Dextrolag¤; Hustex¤; Influbene¤; Migraine-Kranit; Natuscap retard¤; Patussol¤; Pecto-Baby; Rhinofebral; Sine-Off¤; Solmucalm; Triocaps; Tussiplex;
United Kingdom: Dristan¤; Expulin Childrens Cough¤; Expulin Decongestant¤; Expulin¤; Expurhin¤; Galpseud Plus; Haymine; Lemsip Night Time¤; Sine-Off¤; Tixylix Cough & Cold; Triolinctus¤;
United States: 12 Hour Cold¤; 4-Way Cold Tablets¤; Accuhist LA; Aclophen; Advil Allergy Sinus; AeroHist Plus; AeroKid; AH-chew; Aler-Releaf¤; Alersule¤; Alka-Seltzer Plus Cold & Cough¤; Alka-Seltzer Plus Cold & Cough; Alka-Seltzer Plus Cold¤; Alka-Seltzer Plus Cold; Alka-Seltzer Plus Nose & Throat; Allerest 12 Hour¤; Allerest Headache Strength; Allerest Maximum Strength; Allerest Sinus Pain Formula; Allergy Relief Medicine¤; AlleRx; AlleRx; Alumadrine¤; Amerifed; Amerituss AD; Ana-Kit; Anamine¤; Anaplex¤; ARM¤; Aspirin-Free Bayer Select Allergy Sinus; Atrohist Pediatric¤; Atrohist Plus¤; Atuss DM; Atuss HC; Atuss HD; Atuss-12 DM; Bayer Select Flu Relief; BC Multi Symptom Cold Powder¤; Bellahist-D; Biohist-LA; Brexin LA¤; Bronkotuss Expectorant; Ceron-DM; Ceron; Cerose DM; Children’s Allerest¤; Children’s CoTylenol¤; Chlor-Mes D; Chlor-Mes Jr; Chlor-Rest¤; Chlor-Trimeton 12 Hour Relief; Chlor-Trimeton 4 Hour Relief; Chlor-Trimeton Allergy Sinus¤; Chlorafed; Chlordex GP; Chlordrine; Chlorex-A; Chlorgest-HD¤; Chlorphedrine SR; Co-Apap; Co-Hist; Co-Pyronil¤; Codehist DH; Codimal LA¤; Codimal¤; Cold Max¤; Cold Relief¤; Cold Tablets-D¤; Cold Tablets¤; Colfed-A; Comhist LA; Comtrex Allergy-Sinus; Comtrex Day & Night Maximum Strength; Comtrex Day & Night Multi-Symptom; Comtrex Day/Night Flu Therapy; Comtrex Hot Flu Relief; Comtrex Liqui-Gels¤; Comtrex Maximum Strength Night-time Cold & Cough; Comtrex Sinus & Nasal Decongestant; Comtrex; Condrin-LA¤; Congestant D¤; Congestant; Contac 12 Hour¤; Contac Maximum Strength 12 Hour¤; Contac Severe Cold & Flu Hot Medicine¤; Contac Severe Cold & Flu Nighttime¤; Contac Severe Cold and Flu Formula¤; Cophene No. 2; Cordron-HC; Corfen-DM; Coricidin D¤; Coricidin Maximum Strength Sinus Headache¤; Coricidin; Covangesic¤; CP Tannic; CPM PSE MSC; CPM/PE/MSC; Cyndal HD; Cytuss HC; DA Chewable; DA II; Dallergy-D; Dallergy-D; Dallergy-JR; Dallergy; Dapacin Cold¤; De-Chlor DM; De-Chlor DR; De-Chlor HC; De-Chlor HD; Decohistine DH; Deconamine; Decongestabs¤; Decongestant SR¤; Decongestant¤; Decongestant; Deconhist LA¤; Deconomed; Dehist¤; Dehistine; Demazin¤; Derma-Pax; DiHydro-CP; Donatussin; Donatussin; Dorcol Children’s Cold Formula; DriHist; Dristan Cold & Flu; Dristan Cold Multi-Symptom Formula; Dristan Cold; Drize¤; Duadacin Extra Strength Cold & Flu¤; Duadacin¤; Dura-Tap/PD; Dura-Vent/A¤; Dura-Vent/DA; Durahist D; Durahist; Duralex; Ed A-Hist; ED Tuss HC; ED-TLC; Effective Strength Cough Formula; Endagen-HD; Endal-HD Plus; Ex-Histine; Exratuss; Extendryl; Extra Strength Pyrroxate¤; Father John’s Medicine Plus; Fedahist Decongestant¤; Fedahist¤; Flu, Cold & Cough Medicine; Gelhist; Gelpirin-CCF¤; Genacol; Genamin¤; Gencold¤; Gendecon; Hayfebrol; HC Derma-Pax; Hista-Vadrin¤; Hista-Vent DA; Histabid¤; Histade¤; Histadyl and ASA¤; Histafed¤; Histagesic Modified; Histalet Forte¤; Histalet; Histaspan-D¤; Histatab Plus; Histex SR; Histex; Histinex HC; Histinex PV; Histor-D Timecelles; Histor-D; Histussin HC; Hycomine Compound; Hydex PD; Hydro PC; Hydrocodone CP; Hydrocodone HD; Hydron CP; Hydron PSC; Hyphed; HyTan; Iodal; Iotussin HC; Isoclor¤; Kid Kare Childrens Cough/Cold; Kisitan¤; Klerist-D; Kolephrin/DM; Kolephrin; Kophane Cough and Cold Formula¤; Kronofed-A; Lemotussin-DM; Mapap Cold Formula; Maxi-Tuss HCX; Meda Syrup Forte¤; Medatussin Plus¤; Medi-Flu¤; Mescolor¤; Myfedrine Plus¤; Myminic Syrup¤; Myminicol¤; N D Clear; Naldec Pediatric¤; Naldecon¤; Nalex-A 12; Nalex-A; Nalgest¤; Nalspan Pediatric¤; Napril¤; Nasatuss¤; ND-Gesic; New Acute Cold Formula¤; New Decongestant Pediatric¤; Nolamine¤; Norel DM; Norel Plus¤; Norel SD; Notuss PD; Novafed A; Novahistine DH; Novahistine¤; Nuhist; Omnihist LA; Ornade¤; Orthoxicol Cough¤; P-V-Tussin; Panatuss DX; Pancof PD; Pancof-HC; Pancof; Pannaz; Par Decon¤; Para-Hist HD; Parhist SR¤; PCM; PediaCare Childrens Cold & Allergy; PediaCare Childrens Multi-Symptom Cold; Pediacare Cold Formula¤; PediaCare Cough-Cold; PediaCare NightRest Cough-Cold Formula; Pediacof; Pediox; Pedituss Cough; Penntuss¤; Phena-Chlor¤; Phenacon¤; Phenahist-TR¤; Phenapap Sinus Headache & Congestion; Phenate¤; Phenchlor SHA¤; Phenhist DH with Codeine; Polaramine Expectorant; Poly-Tussin; Prehist D; Prehist; Primatuss Cough Mixture 4; Probahist¤; Protid; PSE CPM; Pseudo-Chlor; Pseudo-Gest Plus; QDALL; Quadra Hist¤; Quelidrine; R-Tanna S Pediatric; R-Tanna; R-Tannamine; R-Tannate; Ralix; Relacon-HC; Remcol Cold¤; Remcol-C¤; Rentamine Pediatric; Resaid¤; Rescon-DM; Rescon-ED¤; Rescon-Jr; Rescon-MX; Rescon¤; Respa-ARM¤; Rhinatate-NF; Rhinatate; Rhinogesic¤; Rhinolar-EX¤; Rhinolar¤; Rhinosyn-DM; Rhinosyn; Ricobid¤; Rinade BID¤; Robitussin PM Cough & Cold; Rolatuss Expectorant; Rolatuss Plain; Ru-Tuss II¤; Ru-Tuss¤; Ry-Tuss; Ryna-C¤; Ryna¤; Rynatuss; Ryneze; S-T Forte 2; Salphenyl¤; Scot-Tussin Cough & Cold Medicine¤; Scot-Tussin DM; Silaminic Cold¤; Simplet; Sinapils¤; Sinarest; Sine-Off Maximum Strength Allergy/Sinus; Sine-Off Sinus Medicine¤; Singlet; Sinulin¤; Sinutab Maximum Strength Sinus Allergy; Sinutrex Extra Strength¤; Snaplets-D¤; Snaplets-Multi¤; Spray-ur-Cold¤; Stahist; Sudafed Cold & Allergy; Sudafed Plus; Super Cold Tabs¤; Super Strength Sinadrin¤; T-Dry¤; T-Koff¤; Tanafed DM¤; Tanafed DMX; Tanafed DP; Tanafed¤; Tannic-12; Tanoral; Temazin Cold¤; Thera-Hist¤; TheraFlu Flu and Cold; TheraFlu Flu, Cold & Cough; TheraFlu Severe Cold; Threamine DM¤; Tri-Clear¤; Tri-Nefrin Extra Strength¤; Tri-Phen-Chlor TR¤; Tri-Tannate Plus Pediatric; Tri-Tannate; Triactin¤; Triaminic Allergy¤; Triaminic Chewable¤; Triaminic Cold & Allergy; Triaminic Cold & Cough; Triaminic Cold¤; Triaminic Flu, Cough & Fever; Triaminic Night Time Cough & Cold; Triaminic Softchews; Triaminic-12¤; Triaminic¤; Triaminicin Cold, Allergy, Sinus¤; Triaminicol Multi-Symptom Cough and Cold¤; Triaminicol Multi-Symptom Relief¤; Tricodene Forte¤; Tricodene NN¤; Tricodene Sugar Free; Tricom¤; Triminol Cough¤; Trind¤; Triotann; Tripalgen Cold¤; Triphenyl¤; Tritan; Tusquelin¤; Tuss-Tan; Tussanil DH; Tussanil Plain; Tussar DM; Tussend; Tussi-12; Tussionex Pennkinetic; Tussizone; Ty-Cold¤; Tylenol Allergy Complete Multi-Symptom; Tylenol Allergy Sinus Day & Night; Tylenol Children’s Cold Plus Cough; Tylenol Children’s Cold; Tylenol Childrens Plus Cold Nighttime; Tylenol Cold Complete Formula; Tylenol Cold Effervescent¤; Uni-Decon¤; Unituss HC; Vanex Forte-R¤; Vanex Forte¤; Vanex Grape¤; Vanex-HD; Vicks 44M Cold, Flu & Cough LiquiCaps; Vicks Children’s NyQuil Allergy/Head Cold; Vicks Children’s NyQuil Night-time Cold/Cough Liquid; Vicks Pediatric Formula 44M Multi-Symptom Cough & Cold; Viro-Med¤; Xiral; Xiratuss; Z-Cof HC
He knows everything about medications – to which pharmacological group the drug belongs, what components are included in its composition, how it differs from its analogs, what indications, contraindications, and side effects remedy has. John is a real pro in his field, so he knows all these subtleties and wants to tell you about them.