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Last updated on November 17th, 2021

Drug Approvals

(British Approved Name, US Adopted Name, rINN)

Synonyms: Lormetatsepaami; Lormetazepam; Lormetazepamum; Wy-4082
BAN: Lormetazepam
USAN: Lormetazepam
INN: Lormetazepam [rINN (en)]
INN: Lormetazepam [rINN (es)]
INN: Lormétazépam [rINN (fr)]
INN: Lormetazepamum [rINN (la)]
INN: Лорметазепам [rINN (ru)]
Chemical name: (RS)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-1,4-benzodiazepin-2-one
Molecular formula: C16H12Cl2N2O2 =335.2
CAS: 848-75-9
ATC code: N05CD06
Read code: y01xA

Pharmacopoeias. In British.

BP 2008 (Lormetazepam). A white crystalline powder. Practically insoluble in water soluble in alcohol and in methyl alcohol. Protect from light.


Dependence and Withdrawal

As for Diazepam.

For the purpose of withdrawal regimens, 0.5 to 1 mg of lormetazepam is considered equivalent to about 5 mg of diazepam.

Adverse Effects, Treatment, and Precautions

As for Diazepam.


As for Diazepam.


Lormetazepam is rapidly absorbed from the gastrointestinal tract and metabolised to the inactive glucuronide. The terminal half-life is reported to be about 11 hours.

A brief review of the pharmacokinetics of lormetazepam.

Uses and Administration

Lormetazepam is a short-acting benzodiazepine with general properties similar to those of diazepam. It is mainly used as a hypnotic in the short-term management of insomnia in usual oral doses of 0.5 to 1.5 mg at night. A dose of 500 micrograms is recommended for elderly or debilitated patients. Lormetazepam is also used in some countries for premedication.



British Pharmacopoeia 2008: Lormetazepam Tablets.

Proprietary Preparations

Argentina: Dilamet

Austria: Noctamid

Belgium: Doclormeta Keladormet Loramet Loranka Lormetamed Metatop Noctacalm Noctamid Octonox Sedaben Stilaze

Chile: Norton

Denmark: Pronoctan

France: Noctamide

Germany: Ergocalm Loretam Noctamid

Greece: Loramet

Hong Kong: Loramet

Ireland: Noctamid

Italy: Axilium Ipnolor Luzul Mexylor Minias

The Netherlands: Loramet Noctamid

New Zealand: Noctamid

Poland: Noctofer

Portugal: Noctamid

South Africa: Loramet Noctamid

Singapore: Loramet

Spain: Aldosomnil Loramet Noctamid

Switzerland: Loramet Noctamid

Thailand: Loramet

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