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Lormetazepam

Drug Approvals

(British Approved Name, US Adopted Name, rINN)

Synonyms: Lormetatsepaami; Lormetazepam; Lormetazepamum; Wy-4082
BAN: Lormetazepam
USAN: Lormetazepam
INN: Lormetazepam [rINN (en)]
INN: Lormetazepam [rINN (es)]
INN: Lormétazépam [rINN (fr)]
INN: Lormetazepamum [rINN (la)]
INN: Лорметазепам [rINN (ru)]
Chemical name: (RS)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-1,4-benzodiazepin-2-one
Molecular formula: C16H12Cl2N2O2 =335.2
CAS: 848-75-9
ATC code: N05CD06
Read code: y01xA

Pharmacopoeias. In British.

BP 2008 (Lormetazepam). A white crystalline powder. Practically insoluble in water soluble in alcohol and in methyl alcohol. Protect from light.

Lormetazepam_0.5mg

Dependence and Withdrawal

As for Diazepam.

For the purpose of withdrawal regimens, 0.5 to 1 mg of lormetazepam is considered equivalent to about 5 mg of diazepam.

Adverse Effects, Treatment, and Precautions

As for Diazepam.

Interactions

As for Diazepam.

Pharmacokinetics

Lormetazepam is rapidly absorbed from the gastrointestinal tract and metabolised to the inactive glucuronide. The terminal half-life is reported to be about 11 hours.

A brief review of the pharmacokinetics of lormetazepam.

Uses and Administration

Lormetazepam is a short-acting benzodiazepine with general properties similar to those of diazepam. It is mainly used as a hypnotic in the short-term management of insomnia in usual oral doses of 0.5 to 1.5 mg at night. A dose of 500 micrograms is recommended for elderly or debilitated patients. Lormetazepam is also used in some countries for premedication.

Lormetazepam_1mg

Preparations

British Pharmacopoeia 2008: Lormetazepam Tablets.

Proprietary Preparations

 

Argentina: Dilamet

Austria: Noctamid

Belgium: Doclormeta Keladormet Loramet Loranka Lormetamed Metatop Noctacalm Noctamid Octonox Sedaben Stilaze

Chile: Norton

Denmark: Pronoctan

France: Noctamide

Germany: Ergocalm Loretam Noctamid

Greece: Loramet

Hong Kong: Loramet

Ireland: Noctamid

Italy: Axilium Ipnolor Luzul Mexylor Minias

The Netherlands: Loramet Noctamid

New Zealand: Noctamid

Poland: Noctofer

Portugal: Noctamid

South Africa: Loramet Noctamid

Singapore: Loramet

Spain: Aldosomnil Loramet Noctamid

Switzerland: Loramet Noctamid

Thailand: Loramet

 

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