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Loprazolam Mesilate

Drug Approvals

(British Approved Name Modified, rINNM)

INNs in main languages (French, Latin, and Spanish):

Synonyms: HR-158; Loprazolam Mesylate; Loprazolam Methanesulphonate; Loprazolam, mesilato de; RU-31158
BAN: Loprazolam Mesilate [BANM]
INN: Loprazolam Mesilate [rINNM (en)]
INN: Mesilato de loprazolam [rINNM (es)]
INN: Loprazolam, Mésilate de [rINNM (fr)]
INN: Loprazolami Mesilas [rINNM (la)]
INN: Лопразолама Мезилат [rINNM (ru)]
Chemical name: 6-(2-Chlorophenyl)-2,4-dihydro-2-(4-methylpiperazin-1-ylmethylene)-8-nitroimidazo[1,2-a][1,4]benzodiazepin-1-one methanesulphonate monohydrate
Molecular formula: C23H21ClN6O3,CH4O3S,H2O =579.0
CAS: 61197-73-7 (loprazolam); 70111-54-5 (anhydrous loprazolam mesilate)
ATC code: N05CD11

Pharmacopoeias. In British.

BP 2008 (Loprazolam Mesilate). A yellow crystalline powder. Slightly soluble in water, in alcohol, and in chloroform very slightly soluble in ether.

Dependence and Withdrawal

As for Diazepam.

For the purpose of withdrawal regimens, 0.5 to 1 mg of loprazolam is considered equivalent to about 5 mg of diazepam.

Adverse Effects, Treatment, and Precautions

As for Diazepam.

Porphyria. Loprazolam is considered to be unsafe in patients with porphyria because it has been shown to be porphyrinogenic in in-vitro systems.

dormonoct2mg-Loprazolam

Interactions

As for Diazepam.

Uses and Administration

Loprazolam is an intermediate-acting benzodiazepine with general properties similar to those of diazepam.

Loprazolam mesilate is usually used for its hypnotic properties in the short-term management of insomnia, in usual oral doses equivalent to 1 mg of loprazolam at night. Dosage may be increased to up to 2 mg if necessary. A starting dose of 0.5 mg increased to a maximum of 1 mg may be appropriate for elderly or debilitated patients.

Preparations

BP 2008: Loprazolam Tablets.

Proprietary Preparations

Argentina: Dormonoct

Belgium: Dormonoct

France: Havlane

Germany: Sonin

The Netherlands: Dormonoct

Portugal: Dormonoct

South Africa: Dormonoct

Spain: Somnovit

 

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