Drug Approvals
(US Adopted Name, rINN)
Pharmacopoeias. In China, and Japan.
Dependence and Withdrawal
As for Diazepam.
Adverse Effects, Treatment, and Precautions
As for Diazepam.
Interactions
As for Diazepam.
Pharmacokinetics
Peak plasma concentrations of estazolam are reached on average within 2 hours of oral doses. Estazolam is about 93% protein bound. Reported mean elimination half-lives have generally been in the range of 10 to 24 hours. Estazolam is extensively metabolised, mainly to 4-hydroxyestazolam and 1-oxoestazolam, which are considered inactive. These metabolites are excreted, either free or conjugated, in the urine with small amounts detected in the faeces. Only a small proportion of a dose is excreted as unchanged drug.
Uses and Administration
Estazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. It is given as a hypnotic in the short-term management of insomnia in usual oral doses of 1 to 2 mg at night. Small or debilitated elderly patients may be given an initial dose of 0.5 mg.
Proprietary Preparations
Argentina: Somnatrol
Brazil: Noctal
Denmark: Domnamid
France: Nuctalon
Italy: Esilgan
Japan: Eurodin
Mexico: Tasedan
Philippines: Esilgan
Portugal: Kainever
USA: Prosom
He knows everything about medications – to which pharmacological group the drug belongs, what components are included in its composition, how it differs from its analogs, what indications, contraindications, and side effects remedy has. John is a real pro in his field, so he knows all these subtleties and wants to tell you about them.