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Estazolam

Drug Approvals

(US Adopted Name, rINN)

Synonyms: Abbott-47631; D-40TA; Estatsolaami; Estazolam; Estazolamum
USAN: Estazolam
INN: Estazolam [rINN (en)]
INN: Estazolam [rINN (es)]
INN: Estazolam [rINN (fr)]
INN: Estazolamum [rINN (la)]
INN: Естазолам [rINN (ru)]
Chemical name: 8-Chloro-6-phenyl-4H-1,2,4-triazolo[4,3-a]-1,4-benzodiazepine
Molecular formula: C16H11ClN4 =294.7
CAS: 29975-16-4
ATC code: N05CD04

Pharmacopoeias. In China, and Japan.

Dependence and Withdrawal

As for Diazepam.

Adverse Effects, Treatment, and Precautions

As for Diazepam.

Interactions

As for Diazepam.

Pharmacokinetics

Peak plasma concentrations of estazolam are reached on average within 2 hours of oral doses. Estazolam is about 93% protein bound. Reported mean elimination half-lives have generally been in the range of 10 to 24 hours. Estazolam is extensively metabolised, mainly to 4-hydroxyestazolam and 1-oxoestazolam, which are considered inactive. These metabolites are excreted, either free or conjugated, in the urine with small amounts detected in the faeces. Only a small proportion of a dose is excreted as unchanged drug.

Estazolam_2mg

Uses and Administration

Estazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. It is given as a hypnotic in the short-term management of insomnia in usual oral doses of 1 to 2 mg at night. Small or debilitated elderly patients may be given an initial dose of 0.5 mg.

Proprietary Preparations

 

Argentina: Somnatrol

Brazil: Noctal

Denmark: Domnamid

France: Nuctalon

Italy: Esilgan

Japan: Eurodin

Mexico: Tasedan

Philippines: Esilgan

Portugal: Kainever

USA: Prosom

 

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